Patents by Inventor Mariangela Spitali

Mariangela Spitali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN PURIFICATION
    Publication number: 20220289832
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: May 23, 2022
    Publication date: September 15, 2022
    Inventors: MARIANGELA SPITALI, JONATHAN SYMMONS, RICHARD WHITCOMBE, MARK ROBERT PEARCE-HIGGINS
  • Protein purification
    Patent number: 11339214
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: May 24, 2022
    Assignee: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • PROTEIN PURIFICATION
    Publication number: 20190135909
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: January 16, 2019
    Publication date: May 9, 2019
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Protein purification
    Patent number: 10189897
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: January 29, 2019
    Assignee: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • PROTEIN PURIFICATION
    Publication number: 20160108119
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: December 22, 2015
    Publication date: April 21, 2016
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Protein purification
    Patent number: 9309280
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: April 12, 2016
    Assignee: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Process for obtaining antibodies
    Patent number: 8969036
    Abstract: The present invention relates to the manufacture of recombinant antibodies of therapeutic quality. In particular, the invention relates to methods for increasing the yield of functional antibody from large scale fermentations whereby a cultured host cell sample is subjected to a non-lysing treatment.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: March 3, 2015
    Assignee: UCB Pharma S.A.
    Inventors: Mukesh Sehdev, Mariangela Spitali
  • PROTEIN PURIFICATION
    Publication number: 20130184439
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: July 26, 2011
    Publication date: July 18, 2013
    Applicant: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • E.Coli Host Cells with Modified Phos/Psts Periplasmic Phosphate-binding Proteins, and Method of Manufacturing Recombinant Fabs
    Publication number: 20100285530
    Abstract: The present invention provides an E. coli host cell expressing a recombinant antibody characterized in that the E. coli host cell has been genetically modified in order to change at least one physical property of one or more E. coli proteins which in the wild type co-purify with said recombinant antibody.
    Type: Application
    Filed: December 22, 2009
    Publication date: November 11, 2010
    Applicant: UCB PHARMA S.A.
    Inventors: David Paul Humphreys, Andrew Paul Chapman, Martyn Kim Robinson, Mariangela Spitali
  • host cells with modified PhoS/PstS periplasmic phosphate-binding proteins, and method of manufacturing recombinant fabs
    Patent number: 7662609
    Abstract: The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecoli host cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type copurify with said recombinant antibody.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: February 16, 2010
    Assignee: UCB Pharma S.A.
    Inventors: David Paul Humphreys, Andrew Paul Chapman, Martyn Kim Robinson, Mariangela Spitali
  • Process for Obtaining Antibodies
    Publication number: 20080003644
    Abstract: The present invention relates to the manufacture of recombinant antibodies of therapeutic quality. In particular, the invention relates to methods for increasing the yield of functional antibody from large scale fermentations whereby a cultured host cell sample is subjected to a non-lysing treatment.
    Type: Application
    Filed: November 16, 2005
    Publication date: January 3, 2008
    Applicant: UCB Pharma S.A.
    Inventors: Mukesh Sehdev, Mariangela Spitali
  • Process for Obtaining Antibodies
    Publication number: 20070298462
    Abstract: The present invention relates to the manufacture of recombinant antibodies of therapeutic quality. In particular, the invention relates to methods for increasig the yield of cuntional antibody from large scale fermentations whereby a cultured host cell sample is subjected to a freeze-thaw treatment step.
    Type: Application
    Filed: November 16, 2005
    Publication date: December 27, 2007
    Applicant: UCB Pharma S.A.
    Inventors: Mukesh Sehdev, Mariangela Spitali
  • E.coli host cells with modified phos/psts periplasmic phosphate-binding proteins, and method of manufacturing recombinant fabs
    Publication number: 20070054354
    Abstract: The present invention provides an Ecoli host cell expressing a recombinant antibody characterized in that the Ecoli host cell has been genetically modified in order to change at least one physical property of one or more Ecoli proteins which in the wild type copurify with said recombinant antibody.
    Type: Application
    Filed: October 15, 2003
    Publication date: March 8, 2007
    Applicant: Celltec R & D Limited
    Inventors: David Humphreys, Andrew Chapman, Martyn Robinson, Mariangela Spitali