Patent number: 4451483
Abstract: 2,3,4-trinor-1,5-inter-m-phenylene-prostacycline derivatives of the formula (I), ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1-4 alkyl group, an alkali metal cation or a primary, secondary, tertiary or quaternary ammonium cation,R.sup.2 and R.sup.3 each represent hydrogen or a C.sub.1-4 alkanoyl, benzoyl, substituted benzoyl, tetrahydropyranyl, ethoxyethyl or tri-(C.sub.1-4 alkyl)-silyl group,R.sup.4 is hydrogen or a C.sub.1-4 alkyl group, andR.sup.5 is a hexyl, heptyl, phenoxymethyl or m-trifluoromethylphenoxymethyl group, orR.sup.5 represents a group of the general formula ##STR2## and in this latter formula Z is an amino group or an optionally halo-substituted C.sub.1-4 alkanoylamino, benzoylamino or tosylamino group, andR.sup.6 is a C.sub.
Type:
Grant
Filed:
April 9, 1982
Date of Patent:
May 29, 1984
Assignee:
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.
Inventors:
Istvan Szekely, Krisztina Kekesi, Mariann Lovasz nee Gaspar, Sandor Botar, Pal Hadhazy, Istvan Rakoczi, Laszlo Muszbek, Judit Skopal, Istvan Stadler, Karoly Horvath, Gabor Kovacs, Peter Kormoczy