Patents by Inventor Marianna Max
Marianna Max has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7960128Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: March 7, 2008Date of Patent: June 14, 2011Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7960127Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: February 25, 2008Date of Patent: June 14, 2011Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Publication number: 20090217391Abstract: The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses T1R3 nucleotides, host cell expression systems, T1R3 proteins, fusion protein, transgenic animals that express a T1R3 transgene, and recombinant “knock-out” animals that do not express T1R3. The invention further relates to methods for identifying modulators of the T1R3-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of T1R3 activity may be used as flavor enhancers in food, beverages and pharmaceuticals.Type: ApplicationFiled: July 11, 2008Publication date: August 27, 2009Applicant: Mount Sinai School of Medicine of New York UniversityInventors: Robert MARGOLSKEE, Marianna MAX, Harel WEINSTEIN, Fabien CAMPAGNE, Y. Gopi SHANKER
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Publication number: 20080182266Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: March 7, 2008Publication date: July 31, 2008Applicant: Mount Sinai School of Medicine of New York UniversityInventors: Robert F. MARGOLSKEE, Liquan HUANG, Minqing RONG, Marianna MAX, Cristian A. PEREZ
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Publication number: 20080166743Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: February 25, 2008Publication date: July 10, 2008Applicant: MOUNT SINAI SCHOOL OF MEDICINEInventors: Robert F. MARGOLSKEE, Liquan HUANG, Minqing RONG, Marianna MAX, Cristian A. PEREZ
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Patent number: 7364867Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: April 13, 2001Date of Patent: April 29, 2008Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7341842Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: GrantFiled: April 17, 2006Date of Patent: March 11, 2008Assignee: The Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez
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Patent number: 7314716Abstract: Gustducin is a taste receptor cell heterotrimeric guanine nucleotide binding protein. Disclosed herein is the amino acid sequence of the gamma (?) subunit of gustducin, as well as polynucleotide sequences encoding the ? subunit. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin ? subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: GrantFiled: June 3, 2002Date of Patent: January 1, 2008Assignee: Mount Sinai School of MedicineInventors: Liquan Huang, Robert F. Margolskee, Marianna Max, Y. Gopi Shanker
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Publication number: 20060292548Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: April 17, 2006Publication date: December 28, 2006Applicant: Mount Sinai School of MedicineInventors: Robert Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian Perez
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Publication number: 20040219632Abstract: The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses T1R3 nucleotides, host cell expression systems, T1R3 proteins, fusion protein, transgenic animals that express a T1R3 transgene, and recombinant “knock-out” animals that do not express T1R3. The invention further relates to methods for identifying modulators of the T1R3-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of T1R3 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: April 29, 2004Publication date: November 4, 2004Inventors: Robert Margolskee, Marianna Max, Harel Weinstein, Fabien Campagne, Gopi Y. Shanker
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Publication number: 20030166103Abstract: Gustducin is a taste receptor cell heterotrimeric guanine nucleotide binding protein. Disclosed herein is the amino acid sequence of the gamma (&ggr;) subunit of gustducin, as well as polynucleotide sequences encoding the &ggr; subunit. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin &ggr; subunit, methods for identifying such taste modifying agents and various taste modifying agents.Type: ApplicationFiled: June 3, 2002Publication date: September 4, 2003Inventors: Liquan Huang, Robert F. Margolskee, Marianna Max, Y. Gopi Shanker
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Publication number: 20020037515Abstract: The present invention relates to the discovery, identification and characterization of a transient receptor potential channel, referred to herein as TRP8, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses TRP8 nucleotides, host cell expression systems, TRP8 proteins, fusion proteins, polypeptides and peptides, antibodies to the TRP8 protein, transgenic animals that express a TRP8 transgene, and recombinant “knock-out” animals that do not express TRP8. The invention further relates to methods for identifying modulators of the TRP8-mediated taste response and the use of such modulators to either inhibit or promote the perception of bitterness or sweetness. The modulators of TRP8 activity may be used as flavor enhancers in foods, beverages and pharmaceuticals.Type: ApplicationFiled: April 13, 2001Publication date: March 28, 2002Applicant: Mount Sinai School of MedicineInventors: Robert F. Margolskee, Liquan Huang, Minqing Rong, Marianna Max, Cristian A. Perez