Patents by Inventor Marianne Denise De Backer

Marianne Denise De Backer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the in vitro synthesis of short double stranded RNAs
    Patent number: 7659391
    Abstract: The present invention relates to the field of synthesis of short double-stranded RNAs. An in vitro transcription method using bacteriophage polymerases and target sequence-specific single-stranded DNA oligonucleotides as templates is disclosed. The present invention finds particularly advantageous use in the synthesis of short interfering RNAs (siRNAs) that have been shown to function as key intermediates in triggering sequence-specific RNA degradation during posttranscriptional gene silencing in plants and RNA interference in invertebrates and vertebrate systems.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: February 9, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Marianne Denise De Backer, Adam N. Harris
  • Drug targets in
    Patent number: 7125970
    Abstract: The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequences from Candida albicans are also provided and which encode the polypeptides which are critical for growth of Candida albicans. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: October 24, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Roland Henri Contreras, Bart Jozef Maria Nelissen, Marianne Denise De Backer, Walter Herman Maria Louis Luyten, Jasmine Elza Viaene, Marc George Logghe, Jorge Eduardo Vialard
  • Unusual retrotransposon from the yeast
    Patent number: 7019122
    Abstract: TCa2 is a Tyl/copia retrotransposon from the pathogenic yeast Candida albicans. In contrast to other retrotransposons it can appear as an abundant, extrachromosomal double-stranded DNA molecule, called pCal. The invention relates to the isolation and characterisation of TCa2 and pCal together with its uses for inducing random mutagenesis in a genome, as a component of a transposable element and of an expression vector.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: March 28, 2006
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Russell Tony Masell Poulter, Walter Herman Maria Louis Luyten, Marianne Denise De Backer, Bart Jozef Maria Nelissen
  • Method for the in vitro synthesis of short double stranded rnas
    Publication number: 20040259097
    Abstract: The present invention relates to the field of synthesis of short double-stranded RNAs. An in vitro transcription method using bacteriophage polymerases and target sequence-specific single-stranded DNA oligonucleotides as templates is disclosed. The present invention finds particularly advantageous use in the synthesis of short interfering RNAs (siRNAs) that have been shown to function as key intermediates in triggering sequence-specific RNA degradation during posttranscriptional gene silencing in plants and RNA interference in invertebrates and vertebrate systems.
    Type: Application
    Filed: May 4, 2004
    Publication date: December 23, 2004
    Inventors: Marianne Denise De Backer, Adam N Harris