Patents by Inventor Marianne Van Hage

Marianne Van Hage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant allergen
    Patent number: 9657070
    Abstract: Dander from the domestic cat (Felis domesticus) is one of the most common causes of IgE mediated allergy. The present invention relates to a recombinant folded Fel d 1 with molecular and biological properties similar to the natural counterpart and specifically a synthetic gene coding for a direct fusion of Fel d 1 chain 2 N-terminally to chain 1. E coli expression resulted in a non-covalently associated homodimer with an apparent molecular weight of 30 kDa defined by size exclusion chromatography, each 19177 Da subunit displayed a disulfide pattern identical to that found in the natural Fel d 1, and having identical fold of natural and recombinant Fel d 1. The, recombinant Fel d 1 provides for diagnosis and allergen specific immunotherapy of cat allergy.
    Type: Grant
    Filed: February 20, 2013
    Date of Patent: May 23, 2017
    Assignee: ALK-ABELLO A/S
    Inventors: Hans Gronlund, Marianne van Hage
  • VACCINE CARRIER
    Publication number: 20160257722
    Abstract: The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
    Type: Application
    Filed: December 17, 2015
    Publication date: September 8, 2016
    Applicant: BIOMAY AG
    Inventors: Rudolf VALENTA, Margarete Focke-Tejkl, Birgit Linhart, Susanne Vrtala, Renate Reininger, Susanne Spitzauer, Ines Swoboda, Marianne Van Hage, Hans Gronlund, Johanna Tinhofer, Kerstin Westritschnig, Theresia Popow-Kraupp
  • Vaccine carrier
    Patent number: 9296828
    Abstract: The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: March 29, 2016
    Assignee: BIOMAY AG
    Inventors: Rudolf Valenta, Margarete Focke-Tejkl, Birgit Linhart, Susanne Vrtala, Peter Valent, Renate Reininger, Susanne Spitzauer, Ines Swoboda, Marianne Van Hage, Hans Grönlund, Johanna Tinhofer, Kerstin Westritschnig, Theresia Popow-Kraupp
  • Microparticles comprising carbohydrate beads covalently linked with allergen
    Patent number: 8454964
    Abstract: Microparticles are disclosed which comprise a bead essentially consisting of a cross-linked carbohydrate and an antigen covalently linked thereto. The microparticle can be used for the treatment of disorders of the immune system and in diagnostic tests.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: June 4, 2013
    Assignee: Biomay AG
    Inventors: Hans Groenlund, Johan Roennelid, Alex Karlsson-Parra, Marianne Van Hage-Hamsten, Rudolf Valenta, Susanne Vrtala, Ursula Wiedermann, Dietrich Kraft
  • Vaccine Carrier
    Publication number: 20090324501
    Abstract: The present invention relates to a hypoallergenic protein consisting of at least one hypoallergenic molecule derived from an allergen, which is fused or conjugated to at least one second non-allergenic protein or fragment thereof.
    Type: Application
    Filed: June 11, 2007
    Publication date: December 31, 2009
    Applicant: Biomay AG
    Inventors: Rudolf Valenta, Margarete Focke-Tejkl, Birgit Linhart, Susanne Vrtala, Peter Valent, Renat Reininger, Susanne Spitzauer, Ines Swoboda, Marianne Van Hage, Hans Grönlund, Johanna Tinhofer, Kerstin Westritschnig, Theresia Popow-Kraupp
  • Recombinant allergen
    Publication number: 20090117136
    Abstract: Dander from the domestic cat (Felis domesticus) is one of the most common causes of IgE mediated allergy. The present invention relates to a recombinant folded Fel d 1 with molecular and biological properties similar to the natural counterpart and specifically a synthetic gene coding for a direct fusion of Fel d 1 chain 2 N-terminally to chain 1. E coli expression resulted in a non-covalently associated homodimer with an apparent molecular weight of 30 kDa defined by size exclusion chromatography, each 19177 Da subunit displayed a disulfide pattern identical to that found in the natural Fel d 1, and having identical fold of natural and recombinant Fel d 1. The, recombinant Fel d 1 provides for diagnosis and allergen specific immunotherapy of cat allergy.
    Type: Application
    Filed: April 22, 2004
    Publication date: May 7, 2009
    Applicant: ImVisioN GmbH
    Inventors: Hans Gronlund, Marianne van Hage
  • Microparticles comprising carbohydrate beads covalently linked with allergen
    Publication number: 20050095298
    Abstract: Microparticles are disclosed which comprise a bead essentially consisting of a cross-linked carbohydrate and an antigen covalently linked thereto. The microparticle can be used for the treatment of disorders of the immune system and in diagnostic tests.
    Type: Application
    Filed: April 17, 2003
    Publication date: May 5, 2005
    Inventors: Hans Gronlund, Johan Ronnelid, Alex Karlsson-Parra, Marianne Van Hage-Hamsten, Rudolf Valenta, Susanne Vrtala, Ursula Wiedermann, Dietrick Kraft