Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.

Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.

Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.

Abstract: Security system against the risk of fire comprising a first fire detection element (1) connected by a flexible bridge (3) to a second fire detection element (2), with the first fire detection element (1) having some first means of lighting (4), while the second fire detection element (2) has some means of lighting (5), where the means of lighting are LEDs, in different colors, whereby achieving an easy to position detection system without any installation, that is valid for the deaf and provides information on escape routes. The system is designed to be mounted on the top edge of doors or elements of passage.

Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.

Abstract: The present invention includes a method, kits, and assays for identifying a human subject as having an increased risk of developing an autoimmune disease, or a human subject with multiple sclerosis caused by elevated soluble Interleukin 7 receptor (sIL7R), by obtaining a biological sample and detecting or measuring in the biological sample an amount of a soluble Interleukin-7 receptor (sIL7R) and an amount of an RNA Helicase DDX39B, whereby a lower expression of DDX39B and a higher secretion of sIL7R identifies the subject from which the biological sample was obtained as having an increased risk of developing an autoimmune disease, when compared to a human subject not having an autoimmune disease. The present invention also includes a method of modifying a treating of subjects based on the lower expression of RNA Helicase DDX39B alone or in combination with an increase in sIL7R.

Abstract: This disclosure provides compositions and methods for the isolation of cells that express c-MET, and in particular circulating tumor cells that express c-MET. The methods can include contacting a biological sample including a c-MET circulating tumor cell with an unbound complex including a capture binding species linked to a solid phase for a time sufficient to allow the unbound complex to bind an extracellular binding domain of the c-MET protein to form a bound complex, and subsequently isolating the bound complex. Compositions, systems, and kits adapted for use with these methods are also provided.

Abstract: Security system against the risk of fire comprising a first fire detection element (1) connected by a flexible bridge (3) to a second fire detection element (2), with the first fire detection element (1) having some first means of lighting (4), while the second fire detection element (2) has some means of lighting (5), where the means of lighting are LEDs, in different colours, whereby achieving an easy to position detection system without any installation, that is valid for the deaf and provides information on escape routes. The system is designed to be mounted on the top edge of doors or elements of passage.

Abstract: A torsionally compliant sprocket system includes a first sprocket (250); a second sprocket (230) mounted in side-by-side relation to the first sprocket (250); a resilient member (270) that resiliently couples the second sprocket (230) to the first sprocket (250) to allow limited angular rotation of the second sprocket (230) with respect to the first sprocket (250); and a locking structure (300, 600, 700) that is biased toward an engaged position in which angular motion of the second sprocket (230) with respect to the first sprocket (250) is restrained and moves in response to rotation of the first sprocket (250) to a disengaged position in which angular motion of the second sprocket (230) with respect to the first sprocket (250) is permitted.

Abstract: Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a heterologous gene in a selected cell type. In some embodiments, methods of expressing a heterologous gene in a selected cell type are provided.

Abstract: A torsionally compliant sprocket system includes a first sprocket (250); a second sprocket (230) mounted in side-by-side relation to the first sprocket (250); a resilient member (270) that resiliently couples the second sprocket (230) to the first sprocket (250) to allow limited angular rotation of the second sprocket (230) with respect to the first sprocket (250); and a locking structure (300, 600, 700) that is biased toward an engaged position in which angular motion of the second sprocket (230) with respect to the first sprocket (250) is restrained and moves in response to rotation of the first sprocket (250) to a disengaged position in which angular motion of the second sprocket (230) with respect to the first sprocket (250) is permitted.

Abstract: Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. This invention relates to the identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue. Specifically, it relates to an adult multipotent cell or a cell population or composition comprising said cell, isolated from non-osteochondral mesenchymal tissue, characterized in that it is positive for the following markers: CD9, CD10, CD13, CD29, CD44, CD49A, CD51, CD54, CD55, CD58, CD59, CD90 and CD105 and because it lacks expression of the following markers: CD11b, CD14, CD15, CD16, CD31, CD34, CD45, CD49f, CD102, CD104, CD106 and CD133.

Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stem cells for treating fistulae.

Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.

Abstract: Provided herein are novel methods and composition utilizing adipose tissue-derived stromal stern cells for treating fistulae.

Abstract: The present invention concerns a pharmaceutical composition comprising virtosomes isolated from non-dividing cells or the medium in which the cells are grown, for use in the inhibition of tumor growth and/or prevention of metastases.

Abstract: Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a heterologous gene in a selected cell type. In some embodiments, methods of expressing a heterologous gene in a selected cell type are provided.

Abstract: Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition (EMT) biomarker. Further provided are kits for detecting or isolating CTCs. The kits may include antibodies to at least one EMT biomarker. Further provided are methods of predicting the responsiveness of a subject to a cancer drug, methods of targeting delivery of a cancer drug in a subject, methods of providing a cancer prognosis to a subject, and methods for following the progress of cancer in a subject.

Abstract: Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a heterologous gene in a selected cell type. In some embodiments, methods of expressing a heterologous gene in a selected cell type are provided.

Abstract: Provided herein are novel methods and compositions utilizing adipose tissue-derived stromal stem cells for treating fistulae.