Abstract: An apparatus that is usable with a well includes a tubular assembly and an expansion tool. The tubular assembly has a radially contracted state and includes a restriction. The restriction is adapted to catch an object that is deployed into the well to form a fluid barrier when caught by the restriction. The expansion tool is deployed downhole with the tubular assembly inside a tubing string. The expansion tool is adapted to deform the tubular assembly to anchor the tubular assembly to the tubing string.

Abstract: A fracture plug having V-shaped recessions in a housing and complementary wedges is disclosed. The V-shaped recessions are broader at a top of the fracture plug and narrower toward the bottom and the wedges are complementary to the V-shaped recessions. The wedges have a similar thickness and radius as the housing and the wedges sit within an envelope defined by an exterior and interior radius of the housing.

Abstract: An apparatus that is usable with a well includes a tubular assembly and an expansion tool. The tubular assembly has a radially contracted state and includes a restriction. The restriction is adapted to catch an object that is deployed into the well to form a fluid barrier when caught by the restriction. The expansion tool is deployed downhole with the tubular assembly inside a tubing string. The expansion tool is adapted to deform the tubular assembly to anchor the tubular assembly to the tubing string.

Abstract: A tool for deploying a wellbore plug in a well using flowable eutectic material is disclosed. A tool having a mandrel, an obstruction, and a flowable quantity of eutectic material in a solid state is positioned in the wellbore. The obstruction is actuated and the flowable material is heated to melt. The obstruction supports the flowed material as it cools to form a plug in the wellbore.

Abstract: A tool for deploying a wellbore plug in a well using flowable eutectic material is disclosed. A tool having a mandrel, an obstruction, and a flowable quantity of eutectic material in a solid state is positioned in the wellbore. The obstruction is actuated and the flowable material is heated to melt. The obstruction supports the flowed material as it cools to form a plug in the wellbore.

Abstract: A rigless sand-control tool string is for use in a wellbore having plural zones. The tool string includes plural flow port assemblies, and plural screen assemblies connected to corresponding circulation port assemblies. Each set of one of the flow port assemblies and one of the screen assemblies is configured to perform sand control with respect to a corresponding zone of the wellbore. The flow port assemblies are selectively activatable to allow selective performance of sand control with respect to the corresponding zones.

Abstract: A rigless sand-control tool string is for use in a wellbore having plural zones. The tool string includes plural flow port assemblies, and plural screen assemblies connected to corresponding circulation port assemblies. Each set of one of the flow port assemblies and one of the screen assemblies is configured to perform sand control with respect to a corresponding zone of the wellbore. The flow port assemblies are selectively activatable to allow selective performance of sand control with respect to the corresponding zones.

Abstract: Neurodegenerative diseases, such as dementia, including Alzheimer's disease, can be treated or prevented by administering an effective amount of triflusal or its metabolite, or a pharmaceutically acceptable salt or a prodrug thereof.

Abstract: Neurodegenerative diseases, such as dementia, including Alzheimer's disease, can be treated or prevented by administering an effective amount of triflusal or its metabolite, or a pharmaceutically acceptable salt or a prodrug thereof.

Abstract: A method for inhibiting the activation of transcription factor NF-&kgr;B in a warm-blooded animal in need thereof, comprises administering to said animal an effective amount of a compound of formula I wherein R represents hydrogen or COCH3, or a pharmaceutically acceptable salt or a prodrug thereof.

Abstract: The invention relates to the use of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives as inhibitors of the activation of the nuclear transcription factor NF-&kgr;B. The invention also relates to the utilization of 2-hydroxy-4-trifluoromethylbenzoic acid derivatives for the preparation of medicaments to treat or prevent of pathologies associated to the activation of NF-&kgr;B and/or the expression of genes which are dependent on or regulated by, at least partially, NF&kgr;B in mammals, including humans.

Abstract: 4-alkyl-1,4-dihyropyridines, with PAF-antagonist activity, of formula (I) wherein R is saturated C.sub.1 -C.sub.4, R' is saturated C.sub.1 -C.sub.6 alkyl which may be interrupted by an oxygen atom, or 2-tetrahydrofurfuryl and R.sup.2 is saturated C.sub.1 -C.sub.4 or phenyl, the compound wherein R is methyl, R' is ethyl and R.sup.2 is phenyl remain excluded, are described.The compounds (I) are prepared by: (a) reaction of (II) with (III); (b) reaction of (IV) with (V); (c) reaction of (VI) with (III) and with (VII); (d) reaction of (VIII) with (V) and with (VII); or (e) reaction of (VIII) with (VI) and with (VII) in the presence of ammonia. The compounds (I) are useful due to their antagonist activity of the platelet activating factor.