Patents by Inventor Mariappan Kaliappan

Mariappan Kaliappan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymorphic forms of Dasatinib
    Patent number: 11059813
    Abstract: The present invention provides for the dasatinib-thymine co-crystal and dasatinib-adenine co-crystal. The present invention further provides dasatinib-butanediol solvate. The present invention further provides for crystalline dasatinib-(±)-1, 2-Butanediol, crystalline dasatinib (R)-1, 2-Butanediol, crystalline dasatinib (S)-1, 2-Butanediol and crystalline dasatinib (±)-2, 3-Butanediol and processes for preparation thereof. The present invention also provides for a process for preparation of amorphous dasatinib using dasatinib-butanediol solvate. The present invention further provides for the preparation of anhydrous dasatinib. The present invention also provides for a process for preparation of dasatinib monohydrate from anhydrous dasatinib.
    Type: Grant
    Filed: July 7, 2018
    Date of Patent: July 13, 2021
    Assignee: BIOCON LIMITED
    Inventors: Ramakrishna Parameshwar Bhat, Jithendrababu Raghunadhachetty, Raghavendracharyulu Venkata Palle, Mariappan Kaliappan, Reddy VijayBhaskar Regalla
  • POLYMORPHIC FORMS OF DASATINIB
    Publication number: 20200377495
    Abstract: The present invention provides for the dasatinib-thymine co-crystal and dasatinib-adenine co-crystal. The present invention further provides dasatinib-butanediol solvate. The present invention further provides for crystalline dasatinib-(±)-1,2-Butane diol, crystalline dasatinib (R)-1,2-Butanediol, crystalline dasatinib (S)-1,2-Butanediol and crystalline dasatinib (±)-2,3-Butanediol and processes for preparation thereof. The present invention also provides for a process for preparation of amorphous dasatinib using dasatinib-butanediol solvate. The present invention further provides for the preparation of anhydrous dasatinib.
    Type: Application
    Filed: July 7, 2018
    Publication date: December 3, 2020
    Applicant: Biocon Limited
    Inventors: Ramakrisna Parameshwar BHAT, Jithendrababu RAGHUNADHACHETTY, Raghavendracharyulu Venkata PALLE, Mariappan KALIAPPAN, Reddy VijayBhaskar REGALLA
  • Process for the preparation of teriflunomide
    Patent number: 10526279
    Abstract: The present invention provides a process for the preparation of Teriflunomide (Formula-I). The present invention describes the synthesis of Teriflunomide without isolating the intermediate Leflunomide. Teriflunomide is prepared from 5-Methyl isoxazole-4-carboxylic acid by converting to its acid chloride and coupling with 4-trifluoromethyl aniline to obtain Leflunomide (which is not isolated) followed by ring opening reaction using aq. Sodium Hydroxide to form Teriflunomide. In other words, the process is telescoped from 5-methylisoxazole-4-carbonyl chloride.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: January 7, 2020
    Assignee: BIOCON LIMITED
    Inventors: Venkata Raghavendracharyulu Palle, Ramakrishna Parameshwar Bhat, Mariappan Kaliappan, Jithendra R. Babu, Rajmahendra Shanmughasamy
  • A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE
    Publication number: 20180170859
    Abstract: The present invention provides a process for the preparation of Teriflunomide (Formula-I). The present invention describes the synthesis of Teriflunomide without isolating the intermediate Leflunomide. Teriflunomide is prepared from 5-Methyl isoxazole-4-carboxylic acid by converting to its acid chloride and coupling with 4-trifluoromethyl aniline to obtain Leflunomide (which is not isolated) followed by ring opening reaction using aq. Sodium Hydroxide to form Teriflunomide. In other words, the process is telescoped from 5-methylisoxazole-4-carbonyl chloride.
    Type: Application
    Filed: June 16, 2016
    Publication date: June 21, 2018
    Inventors: Venkata Raghavendracharyulu Palle, Ramakrishna Parameshwar Bhat, Mariappan Kaliappan, Jithendra R. Babu, Rajmahendra Shanmughasamy
  • ACID ADDITION SALTS OF BOSENTAN
    Publication number: 20140275535
    Abstract: The present invention relates to the stable acid addition salts of Bosentan that are useful for the purification of Bosentan base. In particular, the Bosentan acid addition salt is selected from Bosentan citrate and Bosentan tartrate.
    Type: Application
    Filed: December 1, 2011
    Publication date: September 18, 2014
    Applicant: Biocon Limited
    Inventors: Srinivas Pullela Venkata, Kiran Kumar Kothakonda, Shanmughasamy Rajmahendra, Indrajit Chandrasekaran, Mariappan Kaliappan, Rekha Shivappa Mailar