Patents by Inventor Mariarosaria Santillo

Mariarosaria Santillo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diagnosis and therapy of multiple sclerosis
    Patent number: 11505592
    Abstract: The serotonin receptor 5HT2A (5HT2aR) and membrane NADPH oxidases (NOX enzymes) are found to be a target of autoantibodies present in Multiple Sclerosis patients. The present invention refers to peptides comprised in the extracellular regions of the human 5HT2aR and/or NOXs for diagnosis and therapy of Multiple Sclerosis.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: November 22, 2022
    Assignee: PRINDEX S.R.L.
    Inventors: Roberto Paterno, Mariarosaria Santillo, Vittorio Enrico Avvedimento, Luigi Michele Pavone
  • Diagnosis and therapy of Multiple Sclerosis
    Publication number: 20200308251
    Abstract: The serotonin receptor 5HT2A (5HT2aR) and membrane NADPH oxidases (NOX enzymes) are found to be a target of autoantibodies present in Multiple Sclerosis patients. The present invention refers to peptides comprised in the extracellular regions of the human 5HT2aR and/or NOXs for diagnosis and therapy of Multiple Sclerosis.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 1, 2020
    Applicant: PRINDEX S.R.L
    Inventors: Roberto Paterno, Mariarosaria Santillo, Vittorio Enrico Avvedimento, Luigi Michele Pavone
  • Diagnosis and therapy of multiple sclerosis
    Patent number: 10633427
    Abstract: The serotonin receptor 5HT2A (5HT2aR) and membrane NADPH oxidases (NOX enzymes) are found to be a target of autoantibodies present in Multiple Sclerosis patients. The present invention refers to peptides comprised in the extracellular regions of the human 5HT2aR and/or NOXs for diagnosis and therapy of Multiple Sclerosis.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: April 28, 2020
    Assignee: PRINDEX S.R.L.
    Inventors: Roberto Paterno, Mariarosaria Santillo, Vittorio Enrico Avvedimento, Luigi Michele Pavone
  • Diagnosis and therapy of Multiple Sclerosis
    Publication number: 20160376340
    Abstract: The serotonin receptor 5HT2A (5HT2aR) and membrane NADPH oxidases (NOX enzymes) are found to be a target of autoantibodies present in Multiple Sclerosis patients. The present invention refers to peptides comprised in the extracellular regions of the human 5HT2aR and/or NOXs for diagnosis and therapy of Multiple Sclerosis.
    Type: Application
    Filed: June 24, 2016
    Publication date: December 29, 2016
    Inventors: Roberto Paterno, Mariarosaria Santillo, Vittorio Enrico Avvedimento, Luigi Michele Pavone
  • Epitopes of the human PDGF receptor able to bind human auto-antibodies, antibodies and uses thereof
    Patent number: 9150634
    Abstract: The present invention refers to peptides comprised in the extracellular region of human PDGF receptor (hPDGFR) alpha, their use for detecting auto-antibodies anti-hPDGFR alpha and to a method for the diagnosis or the monitoring control for therapy of SSc. The present invention also refers to antibodies or recombinant or synthetic derivatives thereof able to recognize and bind to the above peptide and to their use in the treatment of SSc.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: October 6, 2015
    Inventors: Gianluca Moroncini, Ada Funaro, Armando Gabrielli, Vittorio Enrico Avvedimento, Silvia Svegliati Baroni, Mariarosaria Santillo, Roberto Paterno′
  • METHOD FOR DIAGNOSIS, MONITORING THE EFFICACY OF A THERAPY AND FOR DEVELOPMENT OF TREATMENT FOR MULTIPLE SCLEROSIS
    Publication number: 20130337461
    Abstract: The present invention relates to a method for diagnosis and/or prognosis of multiple sclerosis or to monitor the efficacy of a therapy and/or to screen for a treatment for multiple sclerosis comprising measuring the amount or assessing the cellular localization of one or more specific molecular species in stimulated oligodendrocyte cells.
    Type: Application
    Filed: December 12, 2011
    Publication date: December 19, 2013
    Inventors: Vittorio Enrico Avvedimento, Roberto Paterno', Mariarosaria Santillo
  • EPITOPES OF THE HUMAN PDGF RECEPTOR ABLE TO BIND HUMAN AUTO-ANTIBODIES, ANTIBODIES AND USES THEREOF
    Publication number: 20130130268
    Abstract: The present invention refers to peptides comprised in the extracellular region of human PDGF receptor (hPDGFR) alpha, their use for detecting auto-antibodies anti-hPDGFR alpha and to a method for the diagnosis or the monitoring control for therapy of SSc. The present invention also refers to antibodies or recombinant or synthetic derivatives thereof able to recognize and bind to the above peptide and to their use in the treatment of SSc.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 23, 2013
    Inventors: Gianluca Moroncini, Ada Funaro, Armando Gabrielli, Vittorio Enrico Avvedimento, Silvia Svegliati Baroni, Mariarosaria Santillo, Roberto Paterno'