Patents by Inventor Marie A. Shatos

Marie A. Shatos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues
    Patent number: 10039790
    Abstract: The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present invention is further directed to adult retinal stem cells isolated from vestigial tissue dissected from the eye of a donor mammal suffering from persistent fetal vasculature. The present invention is further directed to a culture medium for growing or maintaining retinal stem cells, and methods of maintaining adult retinal cells in culture. The present invention is further directed to methods of treating a treating an eye with retinal dystrophy using retinal stem cells, and an eye with glaucomatous injury with retinal stem cells. The present invention is further directed to kits for harvesting extra-retinal ocular tissue comprising a sterile container and a harvesting solution, wherein the kit allows the survival of the tissue until later dissociation of cells from the tissue.
    Type: Grant
    Filed: June 19, 2015
    Date of Patent: August 7, 2018
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Kameran Lashkari, Marie Shatos, Tat Fong Ng
  • Isolation and Therapeutic Application of Adult Retinal Stem Cells Collected From Extra-Retinal Tissues
    Publication number: 20160143954
    Abstract: The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present invention is further directed to adult retinal stem cells isolated from vestigial tissue dissected from the eye of a donor mammal suffering from persistent fetal vasculature. The present invention is further directed to a culture medium for growing or maintaining retinal stem cells, and methods of maintaining adult retinal cells in culture. The present invention is further directed to methods of treating a treating an eye with retinal dystrophy using retinal stem cells, and an eye with glaucomatous injury with retinal stem cells. The present invention is further directed to kits for harvesting extra-retinal ocular tissue comprising a sterile container and a harvesting solution, wherein the kit allows the survival of the tissue until later dissociation of cells from the tissue.
    Type: Application
    Filed: June 19, 2015
    Publication date: May 26, 2016
    Inventors: Kameran Lashkari, Marie Shatos, Tat Fong Ng
  • Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues
    Patent number: 9061017
    Abstract: The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present invention is further directed to adult retinal stem cells isolated from vestigial tissue dissected from the eye of a donor mammal suffering from persistent fetal vasculature. The present invention is further directed to a culture medium for growing or maintaining retinal stem cells, and methods of maintaining adult retinal cells in culture. The present invention is further directed to methods of treating a treating an eye with retinal dystrophy using retinal stem cells, and an eye with glaucomatous injury with retinal stem cells. The present invention is further directed to kits for harvesting extra-retinal ocular tissue comprising a sterile container and a harvesting solution, wherein the kit allows the survival of the tissue until later dissociation of cells from the tissue.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: June 23, 2015
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Kameran Lashkari, Marie Shatos, Tat Fong Ng
  • ISOLATION AND THERAPEUTIC APPLICATION OF ADULT RETINAL STEM CELLS COLLECTED FROM EXTRA-RETINAL TISSUES
    Publication number: 20090238800
    Abstract: The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present invention is further directed to adult retinal stem cells isolated from vestigial tissue dissected from the eye of a donor mammal suffering from persistent fetal vasculature. The present invention is further directed to a culture medium for growing or maintaining retinal stem cells, and methods of maintaining adult retinal cells in culture. The present invention is further directed to methods of treating a treating an eye with retinal dystrophy using retinal stem cells, and an eye with glaucomatous injury with retinal stem cells. The present invention is further directed to kits for harvesting extra-retinal ocular tissue comprising a sterile container and a harvesting solution, wherein the kit allows the survival of the tissue until later dissociation of cells from the tissue.
    Type: Application
    Filed: February 15, 2007
    Publication date: September 24, 2009
    Applicant: THE SCHEPENS EYE RESEARCH INSTITUTE, INC.
    Inventors: Kameran Lashkari, Marie Shatos, Tat Fong Ng
  • ISOLATION AND TRANSPLANTATION OF RETINAL STEM CELLS
    Publication number: 20090104694
    Abstract: The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.
    Type: Application
    Filed: November 6, 2008
    Publication date: April 23, 2009
    Applicant: Schepens Eye Research Institute
    Inventors: Michael J. Young, Henry J. Klassen, Marie A. Shatos, Keiko Mizumoto
  • Isolation and transplantation of retinal stem cells
    Patent number: 7514259
    Abstract: The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: April 7, 2009
    Assignee: Schepens Eye Research Institute
    Inventors: Michael J. Young, Henry J. Klassen, Marie A. Shatos, Keiko Mizumoto
  • Culture of goblet cells
    Patent number: 7316927
    Abstract: The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure goblet cells of 10% or greater. In a further embodiment, the invention comprises an immortalized goblet cell line.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: January 8, 2008
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Marie A. Shatos, Darlene A. Dartt, Jose D. Rios
  • Culture of goblet cells
    Publication number: 20070092965
    Abstract: The invention encompasses isolation, culture and characterization of goblet cells in vitro from mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure goblet cells of 10% or greater. In a further embodiment, the invention comprises an immortalized goblet cell line.
    Type: Application
    Filed: May 26, 2006
    Publication date: April 26, 2007
    Inventors: Marie Shatos, Darlene .Dartt, Jose Rios
  • Culture of goblet cells
    Patent number: 7052690
    Abstract: The invention encompasses isolation, culture and characterization of goblet cells in vitro form mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure goblet cells of 10% or greater.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: May 30, 2006
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Marie A. Shatos, Darlene A. Dartt, Jose D. Rios
  • Culture of goblet cells
    Publication number: 20050260172
    Abstract: The invention encompasses isolation, culture and characterization of goblet cells in vitro form mammalian conjuctiva. Goblet cells can be cultured from conjunctiva of such mammals as, e.g., humans, rats, mice, rabbits and the like. In another aspect of the invention, the culture of goblet cells has a concentration of pure goblet cells of 10% or greater.
    Type: Application
    Filed: October 5, 2001
    Publication date: November 24, 2005
    Inventors: Marie Shatos, Darlene Dartt, Jose Rios
  • Isolation and transplantation of retinal stem cells
    Publication number: 20030207450
    Abstract: The present invention relates to the isolation, in vitro propagation, and transplantation and integration of non-pigmented retinal stem cells derived from the neuroretina of the eye, ex vivo and in vivo.
    Type: Application
    Filed: August 6, 2002
    Publication date: November 6, 2003
    Inventors: Michael J. Young, Henry J. Klassen, Marie A. Shatos, Keiko Mizumoto