Patents by Inventor Marie B. Chow

Marie B. Chow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ionically cross-linked polymeric microcapsules
    Patent number: 5308701
    Abstract: A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca.sup.2+ or Al.sup.3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: May 3, 1994
    Inventors: Smadar Cohen, Carmen Bano, Karyn B. Visscher, Marie B. Chow, Harry R. Allcock, Robert S. Langer
  • Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1
    Patent number: 5230888
    Abstract: The production of neutralizing antibodies for poliovirus, or other enteroviruses, are disclosed herein employing the capsid polypeptide VP1. Vaccines can be produced employing this polypeptide in place of killed or live attenuated virus, and the VP1 polypeptide can be employed in assays in place of whole virions. VP1 polypeptide can be produced by isolating it from live virion or can be produced by cloning cDNA sequences coding for this protein in recombinant cDNA vectors.
    Type: Grant
    Filed: May 29, 1990
    Date of Patent: July 27, 1993
    Assignee: Massachusetts Institute of Technology
    Inventors: David Baltimore, Marie B. Chow
  • Production of neutralizing antibodies by polypeptide VP1 of enteroviruses and by oligopeptide fragments of polypeptide VP1
    Patent number: 4751083
    Abstract: The production of neutralizing antibodies for poliovirus, or other enteroviruses, are disclosed herein employing the capsid polypeptide VP1. Vaccines can be produced employing this polypeptide in place of killed or live attenuated virus, and the VP1 polypeptide can be employed in assays in place of whole virions. VP1 polypeptide can be produced by isolating it from live virion or can be produced by cloning cDNA sequences coding for this protein in recombinant cDNA vectors.
    Type: Grant
    Filed: July 20, 1987
    Date of Patent: June 14, 1988
    Assignee: Massachusetts Institute of Technology
    Inventors: David Baltimore, Marie B. Chow