Patents by Inventor Marie-Catherine Giarratana

Marie-Catherine Giarratana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PRODUCING HIGH-DENSITY CULTURE CELLS
    Publication number: 20240409894
    Abstract: The present invention relates to a method for producing cultured cells, comprising a step of culturing cells to be cultured in a perfusion bioreactor containing a culture medium and in which the culture medium is filtered at a bioreactor outlet by a filter, wherein the culture medium comprises at least one nuclease.
    Type: Application
    Filed: September 8, 2022
    Publication date: December 12, 2024
    Inventors: Guillaume Rousseau, Marie-catherine Giarratana, Florent Mathieu, Fanny Rasschaert
  • METHOD FOR PRODUCING CULTURE CELLS REQUIRING A SUPPLY OF FERRIC IRON
    Publication number: 20240191194
    Abstract: The present invention relates to a method for producing cultured cells requiring a supply of ferric iron, comprising a step of culturing cells to be cultured in a perfusion bioreactor containing a culture medium comprising transferrin, wherein the bioreactor is supplied with a source of ferric iron and wherein the culture medium is filtered at the bioreactor outlet by a filter having a cut-off threshold of less than 76 kDa.
    Type: Application
    Filed: March 18, 2022
    Publication date: June 13, 2024
    Inventors: Guillaume ROUSSEAU, Marie-Catherine GIARRATANA, Florent MATHIEU
  • PROCESS FOR PRODUCING CULTURED RED BLOOD CELLS
    Publication number: 20230383256
    Abstract: The invention relates to a process for producing cultured red blood cells from stem cells or cells of an immortalized cell line of the erythroid lineage.
    Type: Application
    Filed: September 23, 2021
    Publication date: November 30, 2023
    Inventors: Guillaume ROUSSEAU, Luc DOUAY, Marie-Catherine GIARRATANA, Florent MATHIEU
  • Cell Culture Medium for the Growth and Differentiation of Cells of the Hematopoietic Lineage
    Publication number: 20160194607
    Abstract: A method for the production of cells of the hematopoietic lineage includes culturing hematopoietic stem cells (HSC) or embryonic bodies with a cell culture medium (the cell culture medium includes insulin at a concentration of from 1 to 50 ?g/ml, transferrin at a concentration of from 100 ?g/ml to 2000 ?g/ml and plasma or serum at a concentration of from 1% to 30%) under conditions allowing producing cells of the hematopoietic lineage; and collecting cells of the hematopoietic lineage.
    Type: Application
    Filed: January 6, 2016
    Publication date: July 7, 2016
    Inventors: Luc Douay, Marie-Catherine Giarratana
  • Cell Culture Medium for the Growth and Differentiation of Cells of the Hematopoietic Lineage
    Publication number: 20130078721
    Abstract: The present invention relates to a cell culture medium for the growth and/or differentiation of cells of the hematopoietic lineage, comprising: —insulin at a concentration of from 1 to 50 ?g/ml; —transferrin at a concentration of from 100 ?g/ml to 2000 ?g/ml; and—plasma or serum at a concentration of from 1% to 30%.
    Type: Application
    Filed: February 21, 2011
    Publication date: March 28, 2013
    Inventors: Luc Douay, Marie-Catherine Giarratana
  • Method for producing red blood cells
    Patent number: 8206979
    Abstract: The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps: a first step in a culture medium, where cell proliferation and erythmid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of the microenvironment, substantially without erythropoietin (EPO). Optionally, the method of culture may comprise an intermediate step, with haematopoietic growth factors.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: June 26, 2012
    Assignee: Universite Pierre et Marie Curie — Paris VI
    Inventors: Marie-Catherine Giarratana, Luc Douay
  • Method for Producing Red Blood Cells
    Publication number: 20070218552
    Abstract: The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps: a first step in a culture medium, where cell proliferation and erythroid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of the microenvironment, substantially without erythropoietin (EPO). Optionally, the method of culture may comprise an intermediate step, with haematopoietic growth factors.
    Type: Application
    Filed: March 11, 2005
    Publication date: September 20, 2007
    Inventors: Marie-Catherine Giarratana, Luc Douay