Abstract: The invention relates to ligands able to bind to microvesicles, comprising a plurality of metal(II)-dipicolylamine moieties and their use in the diagnosis or prognostic of disorders in a subject.

Abstract: The present invention relates to functionalized supports and their use in the diagnosis of pathologies.

Abstract: The present invention relates to polymer particles comprising antibiotics which are deliverable in situ, as well as a method of preparation thereof. The present invention also relates to bioactive biomaterials for the controlled delivery of antibiotics comprising support materials having such polymer particles on their surface. The invention also relates to implants, prostheses, stents, lenses or cements as well as any pharmaceutical composition comprising said biomaterials.

Abstract: A bone substitute material for bone and dental surgery, includes: i) a solid support made from at least one phosphocalcic compound having free hydroxyl groups on the surface, and ii) a quantity of a mimetic peptide of human BMP-2 protein, having a sequence KX1PKX2 Z1Z2X3PTEX4SAISMLYL (SEQ ID No. 3) in which X1, X2, X3 and X4 are nonpolar amino acids, identical or different, and Z1 and Z2, identical or different, represent a cysteine or serine residue, the quantity of mimetic peptide of BMP-2 protein being covalently grafted by the N-terminal end of same to the hydroxyl groups, with a density lower than 100×10?12 mol/mm2 surface area of the solid support. The material, of which the osteoinductive properties are expressed quickly and strongly, is applicable to all fields of bone surgery. A method for producing the material with a controlled grafting density is also claimed.

Abstract: The invention relates to spherical particles formed by polymer chains containing approximately from 30 to 10000 monomer units derived from monocyclic polycyclic alkene polymerization, wherein at least one monomer unit is substituted by an R chain including ethylene polyoxide which is optionally covalently linked to the polymer units through a hydrolyzable bridge and substituted by a reactive function, optionally engaged in a link with an active principle or a biological molecule such as protein, wherein the chain R is covalently linked to the monomer units. The use of the inventive spherical particles for preparing pharmaceutical and cosmetic compositions or surface coatings is also disclosed.

Abstract: The invention relates to biomaterials comprising a carrier material to which surface spherical particles are covalently linked, wherein said spherical particles are formed by polymer chains containing approximately from 30 to 10000 monomer units derived from monocyclic polycyclic alkene polymerisation, are substituted by an R chain comprising ethylene polyoxide which is optionally covalently linked to said polymer units through a hydrolysable bridge and substituted by a reactive function engaged in a link with an active principle, said chain R being covalently linked to said monomer units. The use of the inventive biomaterials for preparing pharmaceutical and cosmetic compositions or surface coatings is also disclosed.