Publication number: 20120252866
Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0.1 or 2, or R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.1 or 2; R2 represents H, XR1, an alkyl group at C1-C6, an aralkyl group at C1-C6 or an aryl group, whereby the alkyl, aralkyl and aryl groups can be substituted by an amine NH2, a carboxylic group COOH, one or more halogen atoms.
Type:
Application
Filed:
April 2, 2012
Publication date:
October 4, 2012
Applicants:
Centre National De La Recherche Scientifique (CNRS), PHARMAMENS
Inventors:
Pierre Potier, Guy Jean Marie Potier, Marie Claude Denise Michele Zelveyan, Catherine Marie Germaine Magnan, Odette Drion, Nobumichi André Sasaki, Maria Concepcion Achab Garcia Alvarez, Qian Wang-Zhu, Lioudmila Ermolenko, Joanna Bakala, Gisèle Franck, Naïma Bakrim Nhiri
Patent number: 7405309
Abstract: The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 carbon atoms, optionally substituted by a hydroxyl, amino, ether or halogen group, or R1 and R2 form together a cycle of 5, 6, 7 or 8 members which is optionally substituted by a hydroxyl, amino, ether or halogen group including isomers, enantiomers, diastereoisomers and the mixtures thereof. A method for preparing the inventive derivatives and the therapeutic use thereof, in particular for treating cancer, are also disclosed.
Type:
Grant
Filed:
January 14, 2005
Date of Patent:
July 29, 2008
Assignee:
Centre National de la Recherche Scientifique (CNRS)
Inventors:
Joanna Bakala, Denyse Herlem, Emile Benechie, Jérôme Bignon, Françoise Khuong-Huu, Guy Jean Marie Potier, legal representative, Marie-Claude Denise Michèle Zelveyan, legal representative, Catherine Marie Germaine Magnan, legal representative, Odette Drion, legal representative, Pierre Potier