Patents by Inventor Marie E. Brown

Marie E. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chondrocyte media formulations and culture procedures
    Patent number: 6150163
    Abstract: One object of the present invention is based upon the development and use of a serum-free defined cell culture medium comprising a supplement mixture, a component mixture, a vitamin mixture, an inorganic salt mixture and amino acid mixture that avoids the problems inherent in the use of serum. In particular, the defined medium is useful in culturing fibroblasts, especially chondrocytes. Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes and enhancing the synthesis of a cartilage specific matrix using tumor growth factor beta (TGF-.beta.). Another object of the present invention is to claim a method of enhancing the differentiation of chondrocytes using the combination of TGF-.beta.and IGF.
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: November 21, 2000
    Assignee: Genzyme Corporation
    Inventors: John M. McPherson, Peter C. Yaeger, Marie E. Brown, James G. Hanlon, Francois Binette