Patents by Inventor Marie-France Makula

Marie-France Makula has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of intra-venously administered gamma-globulins and the gamma-globulins obtained
    Patent number: 4874708
    Abstract: A solution of gamma-globulins, coming for example from Cohn's fractionation, is submitted to a step of fractionation with polyethylene-glycol, a step of moderated enzymatic treatment with pepsin, plasmin or papain, and a step of PEG elimination.
    Type: Grant
    Filed: January 23, 1987
    Date of Patent: October 17, 1989
    Inventors: Marie-France Makula, Jacques Liautaud
  • Process for the preparation of purified albumin and albumin obtained by said process
    Patent number: 4169829
    Abstract: Purified albumin is prepared from frozen placenta, placental blood or other hemolyzed blood by the steps of eliminating hemoglobin, eliminating enzymes and eliminating group substances.
    Type: Grant
    Filed: September 30, 1977
    Date of Patent: October 2, 1979
    Assignee: Institut Merieux
    Inventors: Robert Plan, Jacques Liautaud, Marie-France Makula, Paule Gattel, Jean Pla, Andre Debrus
  • Protein product, a process for preparation, and application of said product
    Patent number: 4137222
    Abstract: A gamma globulin-rich fraction from conventional ethanol fractionation of whole placenta is treated(i) with 17% ethanol at pH 5.1 (itself a conventional step in the fractionation)(ii) the precipitate is diluted with water and dialysed to remove alcohol, then LEDA (2-ethoxy-6, 9-diaminoacridine lactate) is added and the precipitate preferably at pH 7.7 .+-. 0.5 discarded(iii) ammonium sulphate at approximately semi-saturation is added and the precipitate collected.This precipitate contains a proteolytic enzyme (plasmin), assaged by caseinolysis and useful for removal of anti-complement from gamma globulin preparations.
    Type: Grant
    Filed: April 11, 1975
    Date of Patent: January 30, 1979
    Assignee: Institut Merieux
    Inventors: Marie-France Makula, Robert Plan
  • Process for the preparation of purified albumin by thermocoagulation and albumin obtained by said process
    Patent number: 3992367
    Abstract: Purified albumin is prepared from an albumin solution containing foreign or denatured proteins by heating the solution in the presence of caprylic acid at a pH of 4.8 - 5.25 at a temperature between 50.degree. - 64.degree. C. The amount of caprylic acid expressed in weight of sodium caprylate is between 15 - 30% by weight of the proteins in said solution.
    Type: Grant
    Filed: July 3, 1973
    Date of Patent: November 16, 1976
    Assignee: Institut Merieux
    Inventors: Robert A. M. Plan, Jacques C. Liautaud, Marie-France Makula, Paule A. Gattel, Jean F. Pla, Andre J. M. Debrus