Patents by Inventor Marie-Francoise Klucker

Marie-Francoise Klucker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thermoreversible oil-in-water emulsion
    Patent number: 9504659
    Abstract: The invention relates to a thermoreversible oil-in-water emulsion comprising: a TLR4 agonist, the chemical structure of which does not comprise a sugar ring, squalene, a nonionic surfactant belonging to the polyoxyethylene alkyl ether chemical group, a hydrophilic surfactant, an aqueous solvent, and which shows immunostimulating properties.
    Type: Grant
    Filed: January 10, 2007
    Date of Patent: November 29, 2016
    Assignee: Sanofi Pasteur SA
    Inventors: Marie-Françoise Klucker, Jean Haensler, Patricia Probeck-Quelleec, Pascal Chaux
  • Immuno-Adjuvant Emulsion
    Publication number: 20140178478
    Abstract: The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant, which emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm. The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 26, 2014
    Applicant: Sanofi Pasteur
    Inventors: Marie-Francoise Klucker, Francois Dalencon, Patricia Probeck-Quellec
  • Immuno-adjuvant emulsion
    Patent number: 8703095
    Abstract: The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant, which emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm. The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: April 22, 2014
    Assignee: Sanofi Pasteur S.A.
    Inventors: Marie-Francoise Klucker, Francois Dalencon, Patricia Probeck-Quellec
  • Thermoreversible Oil-In-Water Emulsion
    Publication number: 20070191314
    Abstract: The invention relates to a thermoreversible oil-in-water emulsion comprising: a TLR4 agonist, the chemical structure of which does not comprise a sugar ring, squalene, a nonionic surfactant belonging to the polyoxyethylene alkyl ether chemical group, a hydrophilic surfactant, an aqueous solvent, and which shows immunostimulating properties.
    Type: Application
    Filed: January 10, 2007
    Publication date: August 16, 2007
    Applicant: SANOFI PASTEUR SA
    Inventors: Marie-Francoise Klucker, Jean Haensler, Patricia Probeck-Quelleec, Pascal Chaux
  • Immuno-adjuvant emulsion
    Publication number: 20070014805
    Abstract: The invention relates to an oil-in-water adjuvant emulsion which comprises at least: squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant, which emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm. The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process.
    Type: Application
    Filed: July 7, 2006
    Publication date: January 18, 2007
    Applicant: Sanofi Pasteur
    Inventors: Francois Dalencon, Marie-Francoise Klucker, Patricia Probeck-Quellec