Patents by Inventor Marie-Hélène Charles
Marie-Hélène Charles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10407711Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: GrantFiled: December 18, 2018Date of Patent: September 10, 2019Assignee: bioMérieuxInventors: Marie-Hélène Charles, Jean-Philippe Charrier, Myriam-Laure Cubizolles, Agnès Dupont-Filliard, Véronique Lanet, Florence Rivera, Laurent Veron, Lucie Baujard-Lamotte, Christine Peponnet
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Publication number: 20190270958Abstract: An extraction system includes a support bar including a sample well, a reagent well, at least one washing well, and at least one protection and retention housing; a pipetting element removably mounted on the support bar and extending at least partially into the at least one protection and retention housing; and a filtering and transfer device configured to capture and accumulate microorganisms contained in the sample and transfer the captured and accumulated microorganisms, the filtering and transfer device being removably mounted on the support bar and extending at least partially into the at least one protection and retention housing. The filtering and transfer device includes a hollow body having an elongated shape and including a proximal end portion and a distal end portion; and a filtering element fixed to the distal end portion of the hollow body.Type: ApplicationFiled: November 15, 2017Publication date: September 5, 2019Applicant: BIOMÉRIEUXInventors: Patrick BROYER, Marie-Hélène CHARLES, Jérôme BLAZE, Nadine PERROT, Frédéric PINSTON, Hervé ROSTAING
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Publication number: 20190112632Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: ApplicationFiled: December 18, 2018Publication date: April 18, 2019Applicants: bioMérieux, Commissariat à l'Energie Atomique et aux Energies AlternativesInventors: Marie-Hélène CHARLES, Jean-Philippe CHARRIER, Myriam-Laure CUBIZOLLES, Agnès DUPONT-FILLIARD, Véronique LANET, Florence RIVERA, Laurent VERON, Lucie BAUJARD-LAMOTTE, Christine PEPONNET
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Patent number: 10190148Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: GrantFiled: May 2, 2013Date of Patent: January 29, 2019Assignees: bioMérieux, Commissariat à l'Energie Atomique et aux Energies AlternativesInventors: Marie-Hélène Charles, Jean-Philippe Charrier, Myriam-Laure Cubizolles, Agnès Dupont-Filliard, Véronique Lanet, Florence Rivera, Laurent Veron, Lucie Baujard-Lamotte, Christine Peponnet
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Publication number: 20150087003Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.Type: ApplicationFiled: May 2, 2013Publication date: March 26, 2015Applicants: bioMérieux, Commissariat à I'Energie Atomique et aux Energies AlternativesInventors: Marie-Hélène Charles, Jean-Philippe Charrier, Myriam-Laure Cubizolles, Agnès Dupont-Filliard, Véronique Lanet, Florence Rivera, Laurent Veron
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Patent number: 7510843Abstract: The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide sequence in native state corresponds to SEQ ID No 1, SEQ ID No 2, SEQ ID No 3, SEQ ID No 4, SEQ ID No 5, SEQ ID No 6, SEQ ID No 7, SEQ ID No 8, SEQ ID No 9, SEQ ID No 10, SEQ ID No 11, SEQ ID No 12, SEQ ID No 13, SEQ ID No 14, SEQ ID No 15, SEQ ID No 16, SEQ ID No 17, SEQ ID No 18, SEQ ID No 19, SEQ ID No 20, SEQ ID No 21, SEQ ID No 22, SEQ ID No 23, SEQ ID No 24, SEQ ID No 25, SEQ ID No 26, SEQ ID No 27, SEQ ID No 28, and SEQ ID No 29, and the peptide sequences having at least 70% identity, preferably at least 80% identity and advantageously at least 98% identity with any one of the peptide sequences SEQ ID No 1 to SEQ ID No 8 and SEQ ID No 1Type: GrantFiled: June 12, 2006Date of Patent: March 31, 2009Assignee: Biomerieux S.A.Inventors: Dominique Roecklin, Hanno Kolbe, Marie-Helene Charles, Carine Malcus, Lyse Santoro, Herve Perron
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Publication number: 20060223121Abstract: The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide sequence in native state corresponds to SEQ ID No 1, SEQ ID No 2, SEQ ID No 3, SEQ ID No 4, SEQ ID No 5, SEQ ID No 6, SEQ ID No 7, SEQ ID No 8, SEQ ID No 9, SEQ ID No 10, SEQ ID No 11, SEQ ID No 12, SEQ ID No 13, SEQ ID No 14, SEQ ID No 15, SEQ ID No 16, SEQ ID No 17, SEQ ID No 18, SEQ ID No 19, SEQ ID No 20, SEQ ID No 21, SEQ ID No 22, SEQ ID No 23, SEQ ID No 24, SEQ ID No 25, SEQ ID No 26, SEQ ID No 27, SEQ ID No 28, and SEQ ID No 29, and the peptide sequences having at least 70% identity, preferably at least 80% identity and advantageously at least 98% identity with any one of the peptide sequences SEQ ID No 1 to SEQ ID No 8 and SEQ ID No 1Type: ApplicationFiled: June 12, 2006Publication date: October 5, 2006Applicant: BIOMERIEUX STELHYSInventors: Dominique Roecklin, Hanno Kolbe, Marie-Helene Charles, Carine Malcus, Lyse Santoro, Herve Perron
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Patent number: 7081345Abstract: The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide sequence in native state corresponds to SEQ ID No 1, SEQ ID No 2, SEQ ID No 3, SEQ ID No 4, SEQ ID No 5, SEQ ID No 6, SEQ ID No 7, SEQ ID No 8, SEQ ID No 9, SEQ ID No 10, SEQ ID No 11, SEQ ID No 12, SEQ ID No 13, SEQ ID No 14, SEQ ID No 15, SEQ ID No 16, SEQ ID No 17, SEQ ID No 18, SEQ ID No 19, SEQ ID No 20, SEQ ID No 21, SEQ ID No 22, SEQ ID No 23, SEQ ID No 24, SEQ ID No 25, SEQ ID No 26, SEQ ID No 27, SEQ ID No 28, and SEQ ID No 29, and the peptide sequences having at least 70% identity, preferably at least 80% identity and advantageously at least 98% identity with any one of the peptide sequences SEQ ID No 1 to SEQ ID No 8 and SEQ ID No 1Type: GrantFiled: July 17, 2000Date of Patent: July 25, 2006Assignee: Biomerieux StelhysInventors: Dominique Roecklin, Hanno Kolbe, Marie-Hélène Charles, Carine Malcus, Lyse Santoro, Hervé Perron
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Patent number: 6632615Abstract: The invention concerns a method for isolating a target biological material contained in a sample, which consists in providing a capture phase comprising an organic molecule having at least a reactive function and at least a protein material capable of recognizing or binding, specifically and directly or indirectly, with the target biological material, said protein material having a specific covalent binding site with the organic molecule reactive function, consisting of at least a tag comprising at least six contiguous lysine, or lysine derivative residues, the method consists in contacting said target biological material with at least the capture phase; and detecting the target biological material fixed on the capture phase: The invention also concerns the capture and detection phases, and a reagent containing them.Type: GrantFiled: April 21, 1999Date of Patent: October 14, 2003Assignee: Bio MerieuxInventors: Francois Mallet, Thierry DeLair, Catherine Ladaviere, Armelle Novelli-Rousseau, Marie-Helene Charles
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Publication number: 20020192840Abstract: The invention concerns a method for isolating a target biological material contained in a sample, which consists in providing a capture phase comprising an organic molecule having at least a reactive function and at least a protein material capable of recognizing or binding, specifically and directly or indirectly, with the target biological material, said protein material having a specific covalent binding site with the organic molecule reactive function, consisting of at least a tag comprising at least six contiguous lysine, or lysine derivative residues, the method consists in contacting said target biological material with at least the capture phase; and detecting the target biological material fixed on the capture phase: The invention also concerns the capture and detection phases, and a reagent containing them.Type: ApplicationFiled: April 21, 1999Publication date: December 19, 2002Inventors: FRANCOIS MALLET, THIERRY DELAIR, CATHERINE LADAVIERE, ARMELLE NOVELLI-ROUSSEAU, MARIE-HELENE CHARLES
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Publication number: 20020155496Abstract: The invention concerns a saturated or unsaturated abietane derivative of general formula (I) wherein: Z is selected among —COOR5, —CONR1R2, —COONR3R4, —COR6, —CON, —COOR5, —CHOHR7, —SR8, —OR8, —CN, —CNO, —CNS, —NCO, —NCS and —R1R2CR9; wherein R1, R2, R3 and R4 represent a hydrogen atom, a C1-C10 alkyl, a C6-C20 aryl optionally substituted, a C7-C10 alkene, a C1-C10 alkyne, or an aminoacyl or peptidyl optionally substituted; or R1 and R2 or R3 and R4 together form a cycle or a heterocycle; R5 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne, or an aryl optionally substituted into C6-C20; R6 represents a hydrogen, a halogen, a C1-C10 alkyl, a C1-C10 alkene, a C1-C10 alkyne, or an aryl optionally substituted into C6-C20; R7 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, or a C1-C10 alkyne; R8 represents a hydrogen, a C1-C10 alkyl, a C1-C10 alkene, or a C1-C10 alkyne; and R9 is selected amongType: ApplicationFiled: January 30, 2001Publication date: October 24, 2002Inventors: Marie Helene Charles, Nadia Piga, Nicole Battail-Poirot, Laurent Veron, Thierry Delair, Bernard Mandrand
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Patent number: 6033853Abstract: Kit for detecting a specific target nucleic acid sequence using a labeled probe with signal amplification, which comprises in containers (i) a probe labeled with a tracer (ii) a suspension of insoluble particles on which are immobilized at least one series of oligonucleotide units all of which are identical and contain at least one sequence that specifically hybridize with the target nucleic acid sequence and at one sequence that specifically hybridize with tracer labeled probe. A method using the kit is also described.Type: GrantFiled: January 8, 1997Date of Patent: March 7, 2000Assignee: Bio MerieuxInventors: Thierry Delair, Abdelhamid Elaissari, Marie-Helene Charles, Bernard Mandrand
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Patent number: 6017707Abstract: Methods for the detection of a nucleotide sequence of interest comprising at least one nucleotide probe marked with a tracer. The methods include a reagent essentially comprising a linear backbone copolymer having lateral substituents, whose chain consists of a first type of repetitive unit and at least one other type of repetitive unit, in which at least one part of the units of the first type have a lateral substituent comprising a nucleotide unit, such a lateral substituent not being present on the other types of units. Each of said nucleotide units, all of which are identical, comprise at least one nucleotide sequence capable of hybridizing with said sequence of interest and nucleotide sequence capable of hybridizing with a probe, the reagent containing on average more than two of said nucleotide units, in molar equivalents, per mole of polymer. Such a reagent enables signal amplification to be obtained, and therefor lowers the sensitivity threshold.Type: GrantFiled: June 6, 1997Date of Patent: January 25, 2000Assignee: Bio MerieuxInventors: Bernard Mandrand, Philippe Cros, Thierry Delair, Marie-Helene Charles, Marie-Noelle Erout, Christian Pichot
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Patent number: 5760166Abstract: Water-soluble compound derived from a homopolymer or copolymer of maleic anhydride having available anhydride functional groups and hydrolyzed anhydride functional groups, wherein the hydrolyzed anhydride functional groups consist of carboxyl functional groups and functional groups derived from carboxyl functional groups carrying a residue of a compound corresponding to the formula I:C.sub.x H.sub.y A.sub.z O.sub.tin which:A is the nitrogen atom of a primary, secondary or tertiary amine functional group or the sulfur atom of a thiol functional group,x, z and t, independently of each other, are non-zero integers, andy is a non-zero integer, not less than 5 when A is a nitrogen atom and not less than 4 when A is a sulfur atom.Type: GrantFiled: February 2, 1996Date of Patent: June 2, 1998Assignee: Bio MerieuxInventors: Marie-Helene Charles, Thierry Delair, Monique Jaubert, Bernard F. Mandrand
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Patent number: 5723344Abstract: Device for capturing a target molecule for the purpose of detecting it and/or assaying it, including a solid support on which is immobilized a ligand, the ligand being provided in the form of a conjugate resulting from the covalent coupling of a polymer with a plurality of molecules of the ligand. The polymer is an N-vinylpyrrolidone copolymer, and the conjugate is immobilized on the solid support by adsorption.When the ligand is capable of forming a complex with the target, the device is specific for a given target. When the device comprises, in addition, a bifunctional reagent capable of forming a complex, on the one hand, with the ligand and, on the other hand, with the target, the support on which the ligand is immobilized constitutes a universal capturing system.Type: GrantFiled: June 24, 1994Date of Patent: March 3, 1998Assignee: Bio MerieuxInventors: Claude Mabilat, Philippe Cros, Bernard Mandrand, Marie-Helene Charles, Marie-Noelle Erout, Christian Pichot
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Patent number: 5695936Abstract: Methods for the detection of a nucleotide sequence of interest comprising at least one nucleotide probe marked with a tracer. The methods comprise use of a reagent essentially comprising a linear backbone copolymer having lateral substituents, whose chain consists of a first type of repetitive unit and at least one other type of repetitive unit, in which at least one part of the units of the first type have a lateral substituent comprising a nucleotide unit, such a lateral substituent not being present on the other types of units. Each of said nucleotide units, all of which are identical, comprise at least one nucleotide sequence capable of hybridizing with said sequence of interest and nucleotide sequence capable of hybridizing with a probe, the reagent containing on average more than two of said nucleotide units, in molar equivalents, per mole of polymer. Such a reagent enables signal amplification to be obtained, and therefor lowers the sensitivity threshold.Type: GrantFiled: June 14, 1995Date of Patent: December 9, 1997Assignee: Bio MerieuxInventors: Bernard Mandrand, Philippe Cros, Thierry Delair, Marie-Helene Charles, Marie-Noelle Erout, Christian Pichot
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Patent number: 5489653Abstract: Water-soluble compound derived from a homopolymer or copolymer of maleic anhydride having available anhydride functional groups and hydrolyzed anhydride functional groups, wherein the hydrolyzed anhydride functional groups consist of carboxyl functional groups and functional groups derived from carboxyl functional groups carrying a residue of a compound corresponding to the formula I:C.sub.x H.sub.y A.sub.z O.sub.tin which:A is the nitrogen atom of a primary, secondary or tertiary amine functional group or the sulfur atom of a thiol functional group,x, z and t, independently of each other, are non-zero integers, andy is a non-zero integer, not less than 5 when A is a nitrogen atom and not less than 4 when A is a sulfur atom.Type: GrantFiled: March 16, 1993Date of Patent: February 6, 1996Assignee: Bio MerieuxInventors: Marie-Helene Charles, Thierry Delair, Monique Jaubert, Bernard F. Mandrand
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Patent number: 5439972Abstract: Water-soluble compounds derived from a homopolymer or copolymer of maleic anhydride, and applications of the said compounds to supporting biological moleculesWater-soluble compound derived from a homopolymer or copolymer of maleic anhydride having available anhydride functional groups and hydrolyzed anhydride functional groups, wherein the hydrolyzed anhydride functional groups consist of carboxyl functional groups and functional groups derived from carboxyl functional groups carrying a residue of a compound corresponding to the formula I:C.sub.x H.sub.y A.sub.z O.sub.tin which:- A is the nitrogen atom of a primary, secondary or tertiary amine functional group or the sulfur atom of a thiol functional group,- x, z and t, independently of each other, are non-zero integers, and- y is a non-zero integer, not less than 5 when A is a nitrogen atom and not less than 4 when A is a sulfur atom.Type: GrantFiled: October 12, 1994Date of Patent: August 8, 1995Assignee: Bio MerieuxInventors: Marie-Helene Charles, Thierry Delair, Monique Jaubert, Bernard F. Mandrand