Patents by Inventor Marie-Helene Blondelet-Rouault

Marie-Helene Blondelet-Rouault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
    Patent number: 7579167
    Abstract: The present invention relates to the isolation and identification of novel genes of the biosynthetic pathway for spiramycins and to novel polypeptides involved in this biosynthesis. The invention also relates to a method for producing these polypeptides. It also relates to the use of these genes for the purpose of increasing the levels of production and the purity of the spiramycin produced. The invention relates in particular to a microorganism which produces spiramycin I but which does not produce spiramycin II and III, and to the use of such a microorganism. The invention also relates to the use of the genes of the biosynthetic pathway for spiramycins for constructing mutants which can lead to the synthesis of novel antibiotics or to derived forms of spiramycins. The invention also relates to the molecules produced through the expression of these genes and to pharmacologically active compositions of a molecule produced through the expression of such genes.
    Type: Grant
    Filed: October 7, 2003
    Date of Patent: August 25, 2009
    Assignees: Aventis Pharma S., Centre National de la Recherche Scientifique
    Inventors: Marie-Helene Blondelet-Rouault, Helene Dominguez, Emmanuelle Darbon-Rongere, Claude Gerbaud, Anne Gondran, Fatma Karray, Patricia Lacroix, Nathalie Oestreicher-Mermet-Bouvier, Pernodet Jean-Luc, Karine Tuphile
  • Polypeptides involved in the biosynthesis of spiramycins, nucleotide sequences encoding these polypeptides and applications thereof
    Publication number: 20050202528
    Abstract: The present invention relates to the isolation and identification of novel genes of the biosynthetic pathway for spiramycins and to novel polypeptides involved in this biosynthesis. The invention also relates to a method for producing these polypeptides. It also relates to the use of these genes for the purpose of increasing the levels of production and the purity of the spiramycin produced. The invention relates in particular to a microorganism which produces spiramycin I but which does not produce spiramycin II and III, and to the use of such a microorganism. The invention also relates to the use of the genes of the biosynthetic pathway for spiramycins for constructing mutants which can lead to the synthesis of novel antibiotics or to derived forms of spiramycins. The invention also relates to the molecules produced through the expression of these genes and to pharmacologically active compositions of a molecule produced through the expression of such genes.
    Type: Application
    Filed: October 7, 2003
    Publication date: September 15, 2005
    Applicant: Aventis Pharma S.A.
    Inventors: Marie-Helene Blondelet-Rouault, Helene Dominguez, Emmanuelle Darbon-Rongere, Claude Gerbaud, Anne Gondran, Fatma Karray, Patricia Lacroix, Nathalie Oestreicher-Mermet-Bouvier, Jean-Luc Pernodet, Karine Tuphile