Patents by Inventor Marie-Helene Larraufie

Marie-Helene Larraufie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10259827
    Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: April 16, 2019
    Assignee: NOVARTIS AG
    Inventors: Jian Ding, Marie-Helene Larraufie, Deborah Rothman, Nik Savage, Shaowen Wang
  • Publication number: 20180127436
    Abstract: The disclosure provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Also provided are methods of making the compounds of Formula (I) and their methods of use.
    Type: Application
    Filed: November 8, 2017
    Publication date: May 10, 2018
    Inventors: Jian DING, Marie-Helene LARRAUFIE, Deborah ROTHMAN, Nik SAVAGE, Shaowen WANG
  • Patent number: 9938245
    Abstract: The present invention provides, inter alia, compounds having the structure of formula (I): Compositions containing such compounds are also provided. Methods for using such compounds or compositions for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: April 10, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Brent R. Stockwell, Wan Seok Yang, Marie-Helene Larraufie
  • Publication number: 20160332974
    Abstract: The present invention provides, inter alia, compounds having the structure of formula (I): Compositions containing such compounds are also provided. Methods for using such compounds or compositions for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided.
    Type: Application
    Filed: January 14, 2015
    Publication date: November 17, 2016
    Inventors: Brent R. Stockwell, Wan Seok Yang, Marie-Helene Larraufie