Patents by Inventor Marie J. Archer

Marie J. Archer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Large scale preparation method for functionalizing the surface of magnetic microparticles with an inorganic phosphorous dendrimer
    Patent number: 9296771
    Abstract: A method of attaching a phosphorous dendrimer onto magnetic microparticles by taking magnetic microparticles in a water-based solution, then performing a solvent exchange, then suspending the microparticles in a phosphorous dendrimer solution and shaking, then washing the microparticles with an organic solvent, and then washing the microparticles with a transition solvent. The solvent exchange is done by washing the microparticles with a first concentration of a transition solvent, then washing the microparticles with a second concentration of the transition solvent where the second concentration is greater than the first concentration, then washing the microparticles with an organic solvent, then washing the microparticles with the transition solvent, then washing the microparticles with the organic solvent, and then suspending the microparticles in the transition solvent. Also disclosed is the related phosphorous dendrimer made by this method.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 29, 2016
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Marie J. Archer, Baochuan Lin
  • Solid phase for capture of nucleic acids
    Patent number: 9096849
    Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a double-stranded complimentary target nucleic acid; denaturing the target nucleic acids at thermal conditions and in a salt concentration sufficient to denature the target nucleic acids to produce denatured nucleic acids; and cooling the sample to allow hybridization of the denatured nucleic acids to the probe nucleic acids. An article having: one or more paramagnetic microbeads; a dendrimer molecule bound to the beads; and a probe nucleic acid immobilized to the dendrimer.
    Type: Grant
    Filed: May 21, 2007
    Date of Patent: August 4, 2015
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Marie J. Archer, Baochuan Lin, David A Stenger
  • Large scale preparation method for functionalizing the surface of magnetic microparticles with an inorganic phosphorous dendrimer
    Publication number: 20140275628
    Abstract: A method of attaching a phosphorous dendrimer onto magnetic microparticles by taking magnetic microparticles in a water-based solution, then performing a solvent exchange, then suspending the microparticles in a phosphorous dendrimer solution and shaking, then washing the microparticles with an organic solvent, and then washing the microparticles with a transition solvent. The solvent exchange is done by washing the microparticles with a first concentration of a transition solvent, then washing the microparticles with a second concentration of the transition solvent where the second concentration is greater than the first concentration, then washing the microparticles with an organic solvent, then washing the microparticles with the transition solvent, then washing the microparticles with the organic solvent, and then suspending the microparticles in the transition solvent. Also disclosed is the related phosphorous dendrimer made by this method.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: Marie J. Archer, Baochuan Lin
  • METHOD FOR DIRECT CAPTURE OF RIBONUCLEIC ACID
    Publication number: 20100112643
    Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a target ribonucleic acid; denaturing the target ribonucleic acid; and incubating the sample to allow hybridization of the denatured ribonucleic acid to the probe nucleic acids. The target ribonucleic acid is complementary to the probe nucleic acid.
    Type: Application
    Filed: November 4, 2008
    Publication date: May 6, 2010
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Marie J. Archer, Baochuan Lin, David A. Stenger
  • SOLID PHASE FOR CAPTURE OF NUCLEIC ACIDS
    Publication number: 20080293594
    Abstract: A method of: providing a solid surface having a dendrimer molecule bound thereto and a single-stranded probe nucleic acid immobilized to the dendrimer; contacting the solid surface with a sample suspected or known to contain a double-stranded complimentary target nucleic acid; denaturing the target nucleic acids at thermal conditions and in a salt concentration sufficient to denature the target nucleic acids to produce denatured nucleic acids; and cooling the sample to allow hybridization of the denatured nucleic acids to the probe nucleic acids. An article having: one or more paramagnetic microbeads; a dendrimer molecule bound to the beads; and a probe nucleic acid immobilized to the dendrimer.
    Type: Application
    Filed: May 21, 2007
    Publication date: November 27, 2008
    Applicant: The Govermment of the US, as represented by the Secretary of the Navy
    Inventors: Marie J. Archer, Baochuan Lin, David A. Stenger