Patents by Inventor Marie MATSUNAGA

Marie MATSUNAGA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cyclic-di-AMP sodium salt crystal
    Patent number: 11485754
    Abstract: A lyophilized product of cyclic-di-AMP requires special production equipment and is thus not suitable for large-scale production. Crystals of cyclic-di-AMP free acid are unstable under severe conditions at 105° C. Then, the present invention addresses the problem of providing a cyclic-di-AMP crystal that can be easily acquired in a large amount and is very stable under the severe conditions at 105° C. Crystals of c-di-AMP sodium salt according to the present invention are extremely stable even under the severe conditions at 105° C. Further, the crystals of c-di-AMP sodium salt according to the present invention can be prepared in a large amount by a simple process including adjusting a c-di-AMP aqueous solution at pH 5.2-12.0 and then adding an organic solvent thereto.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: November 1, 2022
    Assignee: Yamasa Corporation
    Inventors: Misaki Takamatsu, Ko Yoshida, Marie Matsunaga, Kazuya Ishige
  • CYCLIC-DI-AMP SODIUM SALT CRYSTAL
    Publication number: 20210371451
    Abstract: A lyophilized product of cyclic-di-AMP requires special production equipment and is thus not suitable for large-scale production. Crystals of cyclic-di-AMP free acid are unstable under severe conditions at 105° C. Then, the present invention addresses the problem of providing a cyclic-di-AMP crystal that can be easily acquired in a large amount and is very stable under the severe conditions at 105° C. Crystals of c-di-AMP sodium salt according to the present invention are extremely stable even under the severe conditions at 105° C. Further, the crystals of c-di-AMP sodium salt according to the present invention can be prepared in a large amount by a simple process including adjusting a c-di-AMP aqueous solution at pH 5.2-12.0 and then adding an organic solvent thereto.
    Type: Application
    Filed: October 31, 2019
    Publication date: December 2, 2021
    Inventors: Misaki TAKAMATSU, Ko YOSHIDA, Marie MATSUNAGA, Kazuya ISHIGE