Patents by Inventor Marie-Paule LeFranc

Marie-Paule LeFranc has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of neonatal serological diagnosis
    Patent number: 9493811
    Abstract: The present invention provides a method for determining the amino acid polymorphisms of heavy gamma chain of immunoglobulins G by a proteomic approach. This method distinguishes the immunoglobulins of the mother and those of the newborn in a blood sample obtained during the first months of the child's life. The invention also relates to the use of this method in the early diagnosis of vertically transmitted diseases in the neonate. The invention also provides peptides distinctive of G3m and IGHG3 alleles, and a kit comprising said peptides.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: November 15, 2016
    Assignees: INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD), UNIVERSITE PARIS DESCARTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS
    Inventors: Florence Migot-Nabias, Celia Dechavanne, Francois Guillonneau, Jean-Michel Dugoujon, Marie-Paule Lefranc
  • METHOD OF NEONATAL SEROLOGICAL DIAGNOSIS
    Publication number: 20140178916
    Abstract: The present invention provides a method for determining the amino acid polymorphisms of heavy gamma chain of immunoglobulins G by a proteomic approach. This method distinguishes the immunoglobulins of the mother and those of the newborn in a blood sample obtained during the first months of the child's life. The invention also relates to the use of this method in the early diagnosis of vertically transmitted diseases in the neonate. The invention also provides peptides distinctive of G3m and IGHG3 alleles, and a kit comprising said peptides.
    Type: Application
    Filed: August 10, 2012
    Publication date: June 26, 2014
    Applicants: INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT (IRD), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS, UNIVERSITE PARIS DESCARTES
    Inventors: Florence Migot-Nabias, Celia Dechavanne, Francois Guillonneau, Jean-Michel Dugoujon, Marie-Paule Lefranc
  • Recombinant baculovirus and use thereof in the production of monoclonal antibodies
    Patent number: 6852507
    Abstract: Recombinant baculovirus used as an expression vector in the production of immunoglobulins with an insect cell. The invention is characterized by a first expression cassette comprising a first sequence coding for at least one portion of an immunoglobulin heavy chain, wherein the sequence is transcriptionally controlled by a first baculovirus promoter, and a second expression cassette comprising a second sequence coding for at least one portion of an immunoglobulin light chain, said second sequence being transcriptionally controlled by a second baculovirus promoter. The first and second promoters are two different promoters or derivatives of different promoters, the first and second promoters residing at different loci.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: February 8, 2005
    Assignees: Le Centre National de la Recherche Scientifique
    Inventors: Martine Cerutti, Hassan Chaabihi, Gerard Devauchelle, Laurent Gauthier, Michel Kaczorek, Marie-Paule LeFranc, Marie-Alix Poul