Patents by Inventor Marie-Pierre Krafft

Marie-Pierre Krafft has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080019926
    Abstract: The invention relates to a method for improving the fluidity and/or the spreadability of the native lung surfactant in a human or animal in need of such treatment, wherein the human or animal is administered with a fluorocarbon composition. The invention further relates to therapeutic compositions comprising a fluorocarbon, optionally in combination with a phospholipid, and their use as lung surfactant supplements.
    Type: Application
    Filed: April 18, 2005
    Publication date: January 24, 2008
    Inventors: Marie-Pierre Krafft, Thierry Vandamme, Frederic Gerber, Osamu Shibata
  • Patent number: 6528545
    Abstract: Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formula RF1—W—RH1  (I) wherein RF1 is a linear, branched or cyclic C2-14 fluorocarbon group; RH1 is a linear, branched or cyclic C2-18 saturated or unsaturated hydrocarbon group; and W is absent or is a bivalent species chosen from the group consisting of —O—, —S—, or various fluorinated structures. Use of the fluorophilic/lipophilic compound in the dispersions of the invention provides stable particle size and efficient emulsification. The dispersions of the invention can comprise biologically useful additive and can be used for various purposes, as oxygen carriers, contrast agents, or diagnostic agents.
    Type: Grant
    Filed: June 2, 2000
    Date of Patent: March 4, 2003
    Inventors: Jean G. Riess, Michele Postel, Luis Sole-Violan, Marie-Pierre Krafft, Chantal Cornelus
  • Patent number: 6113919
    Abstract: Fluorocarbon emulsions comprising a stabilizing, particle size controlling fluorophilic/hydrophilic compound which can have the formulaR.sub.F.sup.1 --W--R.sub.H.sup.1 (I)whereinR.sub.F.sup.1 is a linear, branched or cyclic C.sub.2-14 fluorocarbon group;R.sub.H.sup.1 is a linear, branched or cyclic C.sub.2-18 saturated or unsaturated hydrocarbon group; andW is absent or is a bivalent species chosen from the group consisting of --O--, --S--, or various fluorinated structures. Use of the fluorophilic/lipophilic compound in the dispersions of the invention provides stable particle size and efficient emulsification. The dispersions of the invention can comprise biologically useful additive and can be used for various purposes, as oxygen carriers, contrast agents, or diagnostic agents.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 5, 2000
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Jean G. Reiss, Michele Postel, Luis Sole-Violan, Marie-Pierre Krafft, Chantal Cornelus
  • Patent number: 5980936
    Abstract: Multiple emulsions comprising a discontinuous emulsified phase incorporating a highly polar liquid, a second component selected from the group consisting of fluorocarbons and hydrocarbons and a continuous hydrophobic phase are disclosed. In preferred embodiments, the hydrophobic phase may comprise a fluorocarbon or hydrocarbon. Additionally, the stable multiple emulsions of the present invention may further incorporate a bioactive agent and are particularly suitable for drug delivery including pulmonary drug delivery.
    Type: Grant
    Filed: August 7, 1997
    Date of Patent: November 9, 1999
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Marie-Pierre Krafft, Jean G. Riess, Leila Zarif
  • Patent number: 5965258
    Abstract: Microstructures formed from fluorinated amphiphiles and mixed fluorinated and non-fluorinated amphiphiles and having the geometry of tubules, helixes and fibers and methods for preparing them. Tubular forms are capable of encapsulating or incorporating bioactive agents or other useful substances for controlled release in vivo.
    Type: Grant
    Filed: March 16, 1994
    Date of Patent: October 12, 1999
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Jean G. Riess, Francoise Giulieri, Marie-Pierre Krafft, Leila Zarif
  • Patent number: 5904933
    Abstract: Stable reverse water-in-fluorocarbon emulsions and water-in-fluorocarbon-in-water multiple emulsions comprising the reverse fluorocarbon emulsions. The reverse emulsions comprise a continuous phase which is a highly fluorinated or perfluorinated compound, a discontinuous aqueous phase and a fluorinated surfactant or mixture of surfactants. The multiple emulsions comprise an aqueous continuous phase and a discontinuous phase comprising globules formed of aqueous droplets dispersed into a highly fluorinated or perfluorinated compound. The emulsions can contain pharmacologically active agents, and are particularly suitable for pulmonary drug delivery.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 18, 1999
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Jean G. Riess, Marie-Pierre Krafft
  • Patent number: 5733526
    Abstract: Novel hydrocarbon oil/fluorochemical preparations and methods for their use are provided. The preparations, which preferably comprise a fluorophilic dispersing agent, may be in the form of hydrocarbon oil-in-fluorochemical dispersions or in the form of a multiple emulsion comprising a polar liquid continuous phase and are particularly useful for administering bioactive agents. In particular the preparations of the present invention may be used to control the bioavailability and improve the efficacy of lipophilic bioactive agents having limited solubility in an aqueous physiological environment.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: March 31, 1998
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Leo A. Trevino, Jean G. Riess, Luis A. Dellamary, Marie-Pierre Krafft, Thomas E. Tarara
  • Patent number: 5573757
    Abstract: Compositions for topical application in gel form comprising a fluorocarbon or perfluorocarbon compound or mixtures thereof at a concentration of at least about 75% v/v, a minor quantity of a surface active agent and an aqueous phase.The compositions provide a storage-stable high concentration fluorocarbon gel that is prepared without the use of thickeners or additional stabilizing agents. The gels are useful in formulations for pharmaceutical, cosmetic purposes and for other products as well.
    Type: Grant
    Filed: October 3, 1994
    Date of Patent: November 12, 1996
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Jean G. Riess, Marie-Pierre Krafft
  • Patent number: 5344930
    Abstract: Compounds of the general formula: ##STR1## are useful as surfactants in the preparation of fluorocarbon emulsions, which can be used as oxygen-carrying blood substitutes, and for many other therapeutic and diagnostic applications. They are further useful in liposomal formulations which are themselves therapeutic agents or provide a vehicle for such agents.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: September 6, 1994
    Assignee: Alliance Pharmaceutical Corp.
    Inventors: Jean G. Riess, Francois Jeanneaux, Marie-Pierre Krafft, Catherine Santaella, Pierre Vierling