Patents by Inventor Marie-Thérèse Simon-Gage-Soufflot

Marie-Thérèse Simon-Gage-Soufflot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for using HIP/PAP polypeptide composition for liver regeneration and prevention of liver failure
    Patent number: 8329661
    Abstract: This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: December 11, 2012
    Assignees: Instiut National de la Santéet de la Recherche Médicale (INSERM), Universite Rene Descartes
    Inventors: Laurence Christa, Christian Brechot, Marie-Thérèse Simon-Gage-Soufflot, Alain Pauloin, J. Guilherme Tralhao
  • HIP/PAP Polypeptide Composition for Use in Liver Regeneration and for the Prevention of Liver Failure
    Publication number: 20110144036
    Abstract: This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytcs, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No 1, in combination with at least one physiologically acceptable excipient.
    Type: Application
    Filed: February 22, 2011
    Publication date: June 16, 2011
    Applicants: Institut National de la Santé et de la Recherche Médicale (INSERM), Universite Rene Descartes
    Inventors: Laurence Christa, Christian Brechot, Marie-Thérèse Simon-Gage-Soufflot, Alain Pauloin, J. Guilherme Tralhao
  • Hip/pap polypeptide compositions for use in liver regeneration and for the prevention of liver failure
    Publication number: 20060276388
    Abstract: This invention is based on the experimental finding that HIP/PAP has mitogenic and antiapoptotic effects in vitro on hepatocytes in primary culture. Moreover, HIP/PAP is a mitogenic and anti-apoptotic molecule for hepatocytes, in vivo, during liver failure and liver regeneration. The present invention is also based on the experimental finding that HIP/PAP administration has no adverse effects in mammals. This invention concerns a pharmaceutical composition for stimulating liver regeneration in vivo including after chronic/acute liver failure, comprising an effective amount of a polypeptide comprising an amino acid sequence having 90% amino acid identity with the polypeptide consisting of the amino acid sequence starting at the amino acid residue (36) and ending at the amino acid residue (175) of sequence SEQ ID No. 1, in combination with at least one physiologically acceptable excipient.
    Type: Application
    Filed: June 18, 2004
    Publication date: December 7, 2006
    Applicant: Universite Rene Descartes
    Inventors: Laurence Christa, Christian Brechot, Marie-Therese Simon-Gage-Soufflot, Alain Pauloin, J. Guilherme Tralhao