Abstract: The present disclosure relates to the field of endoscopy. Specifically, the present disclosure relates to delivery systems and methods for coagulating sites of bleeding within mucosal tissues, and in particular, for eradicating esophageal varices.

Abstract: The present disclosure relates to the field of endoscopy. Specifically, the present disclosure relates to delivery systems and methods for coagulating sites of bleeding within mucosal tissues, and in particular, for eradicating esophageal varices.

Abstract: The present disclosure relates to the field of endoscopy. Specifically, the present disclosure relates to delivery systems and methods for coagulating sites of bleeding within mucosal tissues, and in particular, for eradicating esophageal varices.

Abstract: A medical implant for a left atrial appendage may include a central member having an anchor at a distal end and a plurality of legs joined together at a joint coupled to the central member. The plurality of legs may be configured to expand from a delivery configuration to a deployed configuration. A medical implant may include a central shaft having an anchor at a distal end and a cup-shaped occluder fixed to a proximal end of the central shaft, the occluder being configured to expand from a delivery configuration to a deployed configuration and retard tissue ingrowth thereon. A medical implant system may include a delivery sheath, an implant having an expandable frame including a plurality of legs each having an anchor and a mesh having a plurality of openings therethrough attached to the frame, and a plurality of particles disposed within the delivery sheath.

Abstract: The present disclosure relates to the field of endoscopy. Specifically, the present disclosure relates to delivery systems and methods for coagulating sites of bleeding within mucosal tissues, and in particular, for eradicating esophageal varices.

Abstract: An implantable medical device includes a body that has a flexible outer layer encapsulating a composition. The composition includes one or more first microspheres, one or more second microspheres, and a carrier. Each first microsphere includes a first therapeutic agent and a wall containing a first biodegradable polymer that encapsulates the first therapeutic agent. Each second microsphere includes a second therapeutic agent and a wall containing a biodegradable polymer that encapsulates the second therapeutic agent.

Abstract: An injectable composition for intravascular delivery of a therapeutic agent includes one or more first microspheres containing a first therapeutic agent, one or more second microspheres containing a second therapeutic agent, and a liquid carrier. The first microspheres includes a wall comprising a biodegradable polymer that encapsulates the first therapeutic agent and the second microspheres includes a wall comprising the biodegradable polymer that encapsulates the second therapeutic agent.

Abstract: A medical implant for a left atrial appendage may include a central member having an anchor at a distal end and a plurality of legs joined together at a joint coupled to the central member. The plurality of legs may be configured to expand from a delivery configuration to a deployed configuration. A medical implant may include a central shaft having an anchor at a distal end and a cup-shaped occluder fixed to a proximal end of the central shaft, the occluder being configured to expand from a delivery configuration to a deployed configuration and retard tissue ingrowth thereon. A medical implant system may include a delivery sheath, an implant having an expandable frame including a plurality of legs each having an anchor and a mesh having a plurality of openings therethrough attached to the frame, and a plurality of particles disposed within the delivery sheath.

Abstract: An implantable heart system for the treatment of a heart with impaired function. The implantable heart system includes a prosthetic heart chamber assembly and a cooperative mechanism. The prosthetic heart chamber assembly comprises a first prosthesis, a second prosthesis, and a prosthetic heart chamber interconnecting the first and second prostheses. One of the prostheses is a valve and the other prosthesis is either a valve or a tubular prosthesis. The cooperative mechanism is selected from the group consisting of an adhesive; an anchor; a filler material; a shape memory element; an expandable member; a pumping agent; material attached to, or forming a part of, the wall of the prosthetic heart chamber; and combinations thereof.

Abstract: An endoprosthesis (e.g., a sleeve) can be used to deliver therapeutic agents to vascular dissections or perforations. The sleeve can have a tissue adhesive and a drug-eluting biodegradable substrate layer.

Abstract: An endoprosthesis (e.g., a sleeve) can be used to deliver therapeutic agents to lesion sites. In some embodiments, one or more sleeves can be delivered to one or more body lumen sites in relatively few intervention procedures. The sleeve can be used to deliver therapeutic agents to a de novo site or the site of a previously deployed stent, or a stent may be co-administered along with one or more sleeves.