Patents by Inventor Marijana Golubovic

Marijana Golubovic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing a protein aggregate and a pharmaceutical preparation
    Patent number: 7777012
    Abstract: The invention relates to a method of preparing a protein aggregate, wherein an aqueous protein solution is acidified with a pH that lies above the isoelectric point of the protein. In accordance with the invention, a first protein, which through acidification is able to form a protein aggregate, is acidified in the presence of a second protein in the aqueous solution in order to form a coaggregate comprising the first and second protein, wherein the second protein under identical temperature conditions and pH does not form a protein aggregate in the absence of the first protein. Acidification preferably occurs with the aid of CO2.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: August 17, 2010
    Assignee: Technische Universiteit Delft
    Inventors: Marijana Golubovic, Marcel Ottens, Geert Jan Witkamp, Lucas Antonius Maria Van Der Wielen
  • Method of Preparing a Protein Aggregate and a Pharmaceutical Preparation
    Publication number: 20080274953
    Abstract: The invention relates to a method of preparing a protein aggregate, wherein an aqueous protein solution is acidified with a pH that lies above the isoelectric point of the protein. In accordance with the invention, a first protein, which through acidification is able to form a protein aggregate, is acidified in the presence of a second protein in the aqueous solution in order to form a coaggregate comprising the first and second protein, wherein the second protein under identical temperature conditions and pH does not form a protein aggregate in the absence of the first protein. Acidification preferably occurs with the aid of CO2.
    Type: Application
    Filed: March 15, 2005
    Publication date: November 6, 2008
    Applicant: Technische Universiteit Delft
    Inventors: Marijana Golubovic, Marcel Ottens, Geert Jan Witkamp, Lucas Antonius Maria Van Der Wielen