Patents by Inventor Marika Nespi

Marika Nespi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20120165329
    Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one of Fms protein kinase or Kit protein kinase.
    Type: Application
    Filed: March 5, 2012
    Publication date: June 28, 2012
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Jiazhong Zhang, Marika Nespi, Hanna Cho
  • Compounds and methods for kinase modulation, and indications therefor
    Patent number: 8158636
    Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one of Fms protein kinase or Kit protein kinase.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: April 17, 2012
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Jiazhong Zhang, Marika Nespi, Hanna Cho
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20120053177
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 1, 2012
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • Compounds and methods for development of Ret modulators
    Patent number: 8067434
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: November 29, 2011
    Assignee: Plexxikon Inc.
    Inventors: Prabha Ibrahim, Dean Richard Artis, Ryan Bremer, Gaston Habets, Clarence R. Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY
    Publication number: 20110230482
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
    Type: Application
    Filed: December 1, 2010
    Publication date: September 22, 2011
    Inventors: Jiazhong Zhang, Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Guoxian Wu, Hongyao Zhu, Marika Nespi, Chao Zhang
  • Compounds modulating c-fms and/or c-kit activity and uses therefor
    Patent number: 7893075
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: February 22, 2011
    Assignee: Plexxikon, Inc.
    Inventors: Jiazhong Zhang, Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Guoxian Wu, Hongyao Zhu, Marika Nespi, Chao Zhang
  • Compounds and methods for development of Ret Modulators
    Publication number: 20100324065
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: April 11, 2008
    Publication date: December 23, 2010
    Inventors: Prabha Ibrahim, Dean Richard Artis, Ryan Bremer, Gaston Habets, Clarence R. Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20100256365
    Abstract: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
    Type: Application
    Filed: November 10, 2009
    Publication date: October 7, 2010
    Inventors: Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Gaston Habets, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong-Liang Zhu, Rebecca Zuckerman, Brian West, Yoshisa Suzuki, James Tsai, Klaus-Peter Hirth, Gideon Bollag, Wayne Spevak, Hanna Cho, Samuel J. Gillette, Guoxian Wu, Hongyao Zhu, Shenghua Shi
  • COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
    Publication number: 20090286782
    Abstract: Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one of Fms protein kinase or Kit protein kinase.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 19, 2009
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Jiazhong Zhang, Marika Nespi, Hanna Cho
  • PDE4B inhibitors
    Patent number: 7605168
    Abstract: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and structural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: October 20, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Prabha N. Ibrahim, Ryan Bremer, Sam Gillette, Hanna Cho, Marika Nespi, Shumeye Mamo, Chao Zhang, Dean R. Artis, Byunghun Lee, Rebecca Zuckerman
  • Compounds modulating c-fms and/or c-kit activity and uses therefor
    Publication number: 20090076046
    Abstract: Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
    Type: Application
    Filed: November 21, 2007
    Publication date: March 19, 2009
    Inventors: Jiazhong Zhang, Prabha N. Ibrahim, Dean R. Artis, Ryan Bremer, Guoxian Wu, Hongyao Zhu, Marika Nespi, Chao Zhang
  • Compounds and methods for development of Ret modulators
    Patent number: 7504509
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and structural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Grant
    Filed: December 17, 2004
    Date of Patent: March 17, 2009
    Assignee: Plexxikon, Inc.
    Inventors: Prabha Ibrahim, Dean Richard Artis, Ryan Bremer, Gaston Habets, Clarence R. Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • Compounds and methods for development of Ret modulators
    Publication number: 20070049615
    Abstract: Compounds active on Ret are described, as well as methods of using such compounds. Also described are crystal structures of Ret surrogates that were determined using X-ray crystallography. The use of such Ret surrogate crystals and strucural information can, for example, be used for identifying molecular scaffolds and for developing ligands that bind to and modulate Ret and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: December 17, 2004
    Publication date: March 1, 2007
    Inventors: Prabha Ibrahim, Dean Artis, Ryan Bremer, Gaston Habets, Clarence Hurt, Shumeye Mamo, Marika Nespi, Chao Zhang, Jiazhong Zhang, Yong Zhu, Rebecca Zuckerman, Heike Krupka, Abhinav Kumar, Brian West
  • PDE4B inhibitors
    Publication number: 20060100218
    Abstract: Compounds are described that are active on PDE4. Also described are crystal structures of PDE4B determined using X-ray crystallography, the use of PDE4B crystals and strucural information for identifying molecular scaffolds, for developing ligands that bind to and modulate PDE4B, and for identifying improved ligands based on known ligands.
    Type: Application
    Filed: September 2, 2005
    Publication date: May 11, 2006
    Inventors: Prabha Ibrahim, Ryan Bremer, Sam Gillette, Hanna Cho, Marika Nespi, Shumeye Mamo, Chao Zhang, Dean Artis, Byunghun Lee, Rebecca Zuckerman