Patents by Inventor Mariko Amano

Mariko Amano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thienotriazolodiazepine compound and pharmaceutical use thereof
    Patent number: 5721231
    Abstract: N-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno ?3,2-f!?1,2,4!triazolo?4,3-a!?1,4!diazepin-6-yl )-N'- (2-methoxyphenyl)urea, optical isomers thereof and pharmaceutically acceptable salts thereof. The compounds of the present invention strongly and selectively inhibit the expression of VCAM-1 and have an inhibitory effect on leukocyte adhesion to vascular endothelial cells. Accordingly, the compounds of the present invention can be used as cell adhesion inhibitors for prophylaxis or treatment of various diseases in which cell adhesion is involved in the onset and progress thereof.
    Type: Grant
    Filed: September 28, 1995
    Date of Patent: February 24, 1998
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Minoru Moriwaki, Hiroyuki Kitani, Syuji Ehara, Hirotsugu Komatsu, Mariko Amano