Patents by Inventor Mariko HORIIKE

Mariko HORIIKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for measuring modified nucleobase using guide probe, and kit therefor
    Patent number: 10138508
    Abstract: The present invention provides a method for measuring a modified nucleobase that increases detection sensitivity for the modified nucleobase in a target nucleic acid. Specifically, the present invention provides a method for measuring a modified nucleobase including: (1) incubating a nucleic acid sample, a capture probe, and a guide probe in a solution; and (2) measuring the modified nucleobase using an antibody against the modified nucleobase in the solution obtained at (1). The present invention also provides a kit for measuring a modified nucleobase including: (I) a guide probe; and (II) a capture probe and/or an antibody against the modified nucleobase.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: November 27, 2018
    Assignee: FUJIREBIO INC.
    Inventors: Tatsuki Matsuno, Mariko Horiike
  • Method for measuring modified nucleobase using solid phase probe, and kit for same
    Patent number: 10107802
    Abstract: The present invention provides a technique that suppresses a background value of a detection signal to construct an immunoassay system that detects a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample, a capture probe, and a solid phase probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase including a capture probe, a solid phase probe, and an antibody against a modified nucleobase.
    Type: Grant
    Filed: August 20, 2014
    Date of Patent: October 23, 2018
    Assignee: FUJIREBIO INC.
    Inventors: Tatsuki Matsuno, Mariko Horiike
  • METHOD AND KIT FOR MEASURING TARGET NUCLEIC ACID CONTAINING MODIFIED NUCLEOBASE
    Publication number: 20170298412
    Abstract: The present invention provides a method and means that can specifically detect a target nucleic acid containing a modified nucleobase. Specifically, the present invention provides a method for measuring a target nucleic acid containing a modified nucleobase, the method comprising: (1) incubating a nucleic acid sample and a heterologous nucleic acid probe having a property of pairing with a modified nucleobase, in a solution; and (2) measuring the modified nucleobase using an antibody against a modified nucleobase having a property of heterologous pairing, in the solution obtained at (1). The present invention also provides a kit for measuring a target nucleic acid containing a modified nucleobase, the kit comprising: (I) a heterologous nucleic acid probe having a property of pairing with a modified nucleobase; and (II) an antibody against a modified nucleobase having a property of heterologous pairing.
    Type: Application
    Filed: September 28, 2015
    Publication date: October 19, 2017
    Applicant: FUJIREBIO INC
    Inventors: Tatsuki MATSUNO, Mariko HORIIKE
  • METHOD FOR MEASURING MODIFIED NUCLEOBASE USING GUIDE PROBE, AND KIT THEREFOR
    Publication number: 20160304934
    Abstract: The present invention provides a method for measuring a modified nucleobase that increases detection sensitivity for the modified nucleobase in a target nucleic acid. Specifically, the present invention provides a method for measuring a modified nucleobase including: (1) incubating a nucleic acid sample, a capture probe, and a guide probe in a solution; and (2) measuring the modified nucleobase using an antibody against the modified nucleobase in the solution obtained at (1). The present invention also provides a kit for measuring a modified nucleobase including: (I) a guide probe; and (II) a capture probe and/or an antibody against the modified nucleobase.
    Type: Application
    Filed: January 19, 2015
    Publication date: October 20, 2016
    Applicant: FUJIREBIO INC.
    Inventors: Tatsuki MATSUNO, Mariko HORIIKE
  • METHOD FOR MEASURING MODIFIED NUCLEOBASE USING SOLID PHASE PROBE, AND KIT FOR SAME
    Publication number: 20160274096
    Abstract: The present invention provides a technique that suppresses a background value of a detection signal to construct an immunoassay system that detects a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample, a capture probe, and a solid phase probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase including a capture probe, a solid phase probe, and an antibody against a modified nucleobase.
    Type: Application
    Filed: August 20, 2014
    Publication date: September 22, 2016
    Applicant: FUJIREBIO INC.
    Inventors: Tatsuki MATSUNO, Mariko HORIIKE
  • METHOD FOR MEASURING MODIFIED NUCLEOBASE USING ABSORBENT POLYNUCLEOTIDE AND KIT FOR SAME
    Publication number: 20160202249
    Abstract: An object of the present invention is to provide a technique that suppresses a background value of a detection signal to construct an immunoassay system for detecting a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase including incubating a nucleic acid sample and a capture probe in a solution and measuring a modified nucleobase using an antibody against the modified nucleobase in the presence of an absorbent polynucleotide in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase including a capture probe, an absorbent polynucleotide, and an antibody against a modified nucleobase.
    Type: Application
    Filed: August 20, 2014
    Publication date: July 14, 2016
    Applicant: FUJIREBIO INC.
    Inventors: Tatsuki MATSUNO, Mariko HORIIKE
  • METHOD AND KIT FOR MEASURING MODIFIED NUCLEOBASE USING HETEROGENEOUS NUCLEIC ACID PROBE
    Publication number: 20160187325
    Abstract: The present invention provides a technique that suppresses a background value of a detection signal to construct an immunoassay system that detects a modified nucleobase. Specifically, the present invention provides a method for measuring a modified nucleobase comprising incubating a nucleic acid sample (e.g., a sample containing a target DNA containing the modified nucleobase) and a heterogeneous nucleic acid probe (e.g., an RNA probe) in a solution and measuring the modified nucleobase using an antibody against the modified nucleobase in the obtained solution. The present invention also provides a kit for measuring a modified nucleobase comprising a heterogeneous nucleic acid probe and an antibody against the modified nucleobase.
    Type: Application
    Filed: August 20, 2014
    Publication date: June 30, 2016
    Inventors: Tatsuki MATSUNO, Mariko HORIIKE