Abstract: The present invention relates to a medicament for treating or preventing central nervous system disease whose cause is related to abnormal aggregation of proteins in the brain, which comprises as an active ingredient a compound of formula (1) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are hydrogen, etc., R3 and R4 are hydrogen, C1-6 alkyl, etc., R5 is halogen, C1-6 alkyl, etc., R6 is hydrogen, halogen, etc., X is oxygen, etc., Y is carbon, etc., m and n are an integer of 0, 1, etc., r and s are 0, 1, 2, etc., Hy is pyridine ring, etc., which has an action of suppressing or reducing the accumulation of abnormal aggregation of proteins in the brain.

Abstract: An autonomous moving apparatus includes a moving unit that moves the autonomous moving apparatus, a detector that detects distances from surrounding objects and shapes of the surrounding objects, a notifying unit that notifies surrounding persons, and a controller that controls the moving unit so that the autonomous moving apparatus moves so as to follow movement of a person recognized as a follow target by the detector and, when the person recognized as the follow target performs a specific action, controls the notifying unit to give a notification by a preset notification method in response to the specific action.

Abstract: TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia.

Abstract: An ophthalmologic apparatus according to an exemplary embodiment acquires data by OCT scanning of the anterior eye segment. The apparatus generates distribution information of a predetermined parameter in the anterior eye segment by analyzing the data. The apparatus acquires a front image of the anterior eye segment at the time of the data being acquired. The apparatus stores the first distribution information and the first front image both corresponding to the first time, and the second distribution information and the second front image both corresponding to the second time. The apparatus calculates the positional difference between the first front image and the second front image. The apparatus applies registration to the first distribution information and the second distribution information based on the positional difference.

Abstract: An ophthalmologic apparatus according to an exemplary embodiment acquires data by OCT scanning of the anterior eye segment. The apparatus generates distribution information of a predetermined parameter in the anterior eye segment by analyzing the data. The apparatus acquires a front image of the anterior eye segment at the time of the data being acquired. The apparatus stores the first distribution information and the first front image both corresponding to the first time, and the second distribution information and the second front image both corresponding to the second time. The apparatus calculates the positional difference between the first front image and the second front image. The apparatus applies registration to the first distribution information and the second distribution information based on the positional difference.

Abstract: TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia.

Abstract: A lens meter includes a measurement optical system that projects measurement light to a test lens, and receives the measurement light which has passed through the test lens, a control part that calculates an optical characteristic value of the test lens based on the received measurement light, and controls the measurement optical system, a display part that displays the optical characteristic value by control of the control part, and an imaging part that obtains a lens image of the test lens, wherein the control part generates a mapping image showing distribution of the optical characteristic value of the test lens based on the optical characteristic value and position information of a measurement position of the optical characteristic value, generates a superimposed image in which the mapping image is superimposed onto the lens image, and displays the superimposed image on the display part.

Abstract: A lens meter includes a measurement optical system that projects measurement light to a test lens, and receives the measurement light which has passed through the test lens, a control part that calculates an optical characteristic value of the test lens based on the received measurement light, and controls the measurement optical system, a display part that displays the optical characteristic value by control of the control part, and an imaging part that obtains a lens image of the test lens, wherein the control part generates a mapping image showing distribution of the optical characteristic value of the test lens based on the optical characteristic value and position information of a measurement position of the optical characteristic value, generates a superimposed image in which the mapping image is superimposed onto the lens image, and displays the superimposed image on the display part.

Abstract: TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia.

Abstract: TRPV4 activation increases vascular permeability and can be triggered by both chemical and mechanical cues. This activation of TRPV4 can contribute to a number of pathological conditions, e.g., edema, inflammation, hypertension, and/or hyperalgesia. Described herein are methods and compositions relating to inhibition of mechanically-induced TRPV4 activation, e.g., for the treatment of pulmonary edema, edema, inflammation, hypertension, and/or hyperalgesia.

Abstract: One aspect of the present disclosure relates to a tissue imaging device that includes a catheter body, a hood, and a visualization assembly. The catheter body includes a distal end portion, a proximal end portion, and at least one lumen extending between the distal and proximal end portions. The catheter body includes at least one drainage port having a first opening and at least one infusion port having a second opening. The first and second openings are located about a lateral aspect of the catheter body. The hood projects distally from the distal end portion and is configured to self-expand into an expanded deployment state that defines an open area therein. The visualization assembly is disposed within the open area and extends distally from the distal end portion of the catheter body.

Abstract: Treatment of heart failure in a patient by electrically modulating both the sympathetic and parasympathetic autonomic cardiac nerve fibers that innervate the patient's heart at an extravascular site in the pericardial space of the heart. The extravascular site is any suitable single location inside the chest cavity that carries both sympathetic and parasympathetic cardiac nerves such as the cardiac plexus or the pericardial transverse sinus or any two separate extravascular sites with one site carrying predominantly sympathetic cardiac nerves and the other site carrying predominantly parasympathetic cardiac nerves for electrically modulating the balance of autonomic cardiac nerve control.

Abstract: One aspect of the present disclosure relates to a tissue imaging device that includes a catheter body, a hood, and a visualization assembly. The catheter body includes a distal end portion, a proximal end portion, and at least one lumen extending between the distal and proximal end portions. The catheter body includes at least one drainage port having a first opening and at least one infusion port having a second opening. The first and second openings are located about a lateral aspect of the catheter body. The hood projects distally from the distal end portion and is configured to self-expand into an expanded deployment state that defines an open area therein. The visualization assembly is disposed within the open area and extends distally from the distal end portion of the catheter body.

Abstract: Treatment of heart failure in a patient by electrically modulating both the sympathetic and parasympathetic autonomic cardiac nerve fibers that innervate the patient's heart at an extravascular site in the pericardial space of the heart. The extravascular site is any suitable single location inside the chest cavity that carries both sympathetic and parasympathetic cardiac nerves such as the cardiac plexus or the pericardial transverse sinus or any two separate extravascular sites with one site carrying predominantly sympathetic cardiac nerves and the other site carrying predominantly parasympathetic cardiac nerves for electrically modulating the balance of autonomic cardiac nerve control.

Abstract: The present invention relates to a system having an information image management server, an advertising agency terminal and a client computer connected with one another via a network, in which the information image management server extracted a client computer which meets a client specifying condition on the basis of client specifying condition information from the advertising agency terminal, then a message to carry out update or addition of an information image recorded in a management area of the extracted client computer is transmitted to the extracted client, and the client computer which has received the message carries out update or addition of an information image in accordance with the message.

Abstract: An eye examination apparatus 100 of the present invention comprises, a refractive power measuring section 50 for measuring refractive powers of subject eyes E of a subject in a binocular viewing state, an eye chart presenting section 30 for presenting a subjective measurement eye chart to be observed by the subject, a correcting section 40 for correcting the subject eyes by referring to data on the refractive powers measured with the refractive power measuring section 50 and using the subjective measurement eye chart presented in the eye chart presenting section 30 and an optical characteristics measuring section 10 for subjectively measuring an optical characteristic of the subject eyes E corrected or being corrected with the correcting section 40 in a state where the subject is binocularly viewing the subjective measurement eye chart.

Abstract: There is provided a Shack-Hartmann wavefront sensor which can repetitively perform a measurement at high speed and at short measurement intervals. An illuminating optical system includes a first polarizing optical member to alternately change a polarization condition to a first polarized light or a second polarized light, and illuminates a pulse light from a laser light source part to an ocular fundus of a subject eye through a first polarizing optical member. A light receiving optical system includes a second polarizing optical member to select each polarized light component of the reflected light from the subject eye illuminated according to the polarization condition of the first polarizing optical member, and a first and a second light receiving parts to alternately receive the reflected light of the selected polarized light component.

Abstract: To provide an eye examination apparatus and an eye examination method that make it possible to measure eyesight or contrast sensitivity in the binocular viewing state and further make it possible to measure optical characteristics in such an appropriate binocular viewing state.

Abstract: There is provided a Shack-Hartmann wavefront sensor which can repetitively perform a measurement at high speed and at short measurement intervals. An illuminating optical system includes a first polarizing optical member to alternately change a polarization condition to a first polarized light or a second polarized light, and illuminates a pulse light from a laser light source part to an ocular fundus of a subject eye through a first polarizing optical member. A light receiving optical system includes a second polarizing optical member to select each polarized light component of the reflected light from the subject eye illuminated according to the polarization condition of the first polarizing optical member, and a first and a second light receiving parts to alternately receive the reflected light of the selected polarized light component.

Abstract: The present invention relates to a system having an information image management server, an advertising agency terminal and a client computer connected with one another via a network, in which the information image management server extracted a client computer which meets a client specifying condition on the basis of client specifying condition information from the advertising agency terminal, then a message to carry out update or addition of an information image recorded in a management area of the extracted client computer is transmitted to the extracted client, and the client computer which has received the message carries out update or addition of an information image in accordance with the message.