Patents by Inventor Mariko KYUTOKU

Mariko KYUTOKU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY-DRUG CONJUGATE INCLUDING NOVEL CYCLIC DINUCLEOTIDE DERIVATIVE
    Publication number: 20230330248
    Abstract: [Problem] It is desired to develop an antibody-drug conjugate capable of being systemically administered and delivering a STING agonist specifically to a target cells or organ (for example, a tumor lesion), and a therapeutic agent and/or therapeutic method using the antibody-drug conjugate for diseases related to STING agonist activity, for example, diseases (for example, cancers) to which immunostimulation therapy can be applied. [Solution] The present invention provides a novel antibody-CDN derivative conjugate which can be systemically administered and exhibits an antitumor effect against an antigen-expressing tumor.
    Type: Application
    Filed: March 5, 2021
    Publication date: October 19, 2023
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Masayuki ISHIZAKI, Osamu SUZUKI, Mariko KYUTOKU, Hiroshi YUKIURA, Kyoko HARA, Masataka CHIHARA, Takafumi OTSUKA, Teiji WADA
  • DNA vaccine containing VEGF-specific epitope and/or angiopoietin-2-specific epitope
    Patent number: 10543261
    Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: January 28, 2020
    Assignees: Osaka University, AnGes, Inc.
    Inventors: Hironori Nakagami, Mariko Kyutoku, Ryuichi Morishita, Hideki Tomioka
  • DNA vaccine containing specific epitope of apolipoprotein (a)
    Patent number: 9913886
    Abstract: The present invention provides an agent for the treatment or prophylaxis of arteriosclerosis comprising an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of apolipoprotein (a), wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
    Type: Grant
    Filed: July 1, 2016
    Date of Patent: March 13, 2018
    Assignee: AnGes, Inc.
    Inventors: Mariko Kyutoku, Hironori Nakagami, Hiroshi Koriyama, Futoshi Nakagami, Ryuichi Morishita
  • DNA VACCINE CONTAINING SPECIFIC EPITOPE OF APOLIPOPROTEIN (a)
    Publication number: 20160303211
    Abstract: The present invention provides an agent for the treatment or prophylaxis of arteriosclerosis comprising an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of apolipoprotein (a), wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
    Type: Application
    Filed: July 1, 2016
    Publication date: October 20, 2016
    Applicant: AnGesMG, Inc.
    Inventors: Mariko KYUTOKU, Hironori NAKAGAMI, Hiroshi KORIYAMA, Futoshi NAKAGAMI, Ryuichi MORISHITA
  • DNA VACCINE CONTAINING VEGF-SPECIFIC EPITOPE AND/OR ANGIOPOIETIN-2-SPECIFIC EPITOPE
    Publication number: 20150202271
    Abstract: The present invention provides a therapeutic or prophylactic agent for cancer, containing an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of VEGF and/or a specific epitope of angiopoietin-2, wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
    Type: Application
    Filed: August 28, 2013
    Publication date: July 23, 2015
    Inventors: Hironori Nakagami, Mariko Kyutoku, Ryuichi Morishita, Hideki Tomioka
  • DNA VACCINE CONTAINING SPECIFIC EPITOPE OF APOLIPOPROTEIN (a)
    Publication number: 20140086944
    Abstract: The present invention provides an agent for the treatment or prophylaxis of arteriosclerosis comprising an expression vector encoding a chimeric Hepatitis B virus core antigen polypeptide inserted with an amino acid sequence containing a specific epitope of apolipoprotein (a), wherein the amino acid sequence containing the specific epitope is inserted between the amino acid residues 80 and 81 of the hepatitis B virus core antigen polypeptide.
    Type: Application
    Filed: September 20, 2013
    Publication date: March 27, 2014
    Inventors: Mariko KYUTOKU, Hironori NAKAGAMI, Hiroshi KORIYAMA, Futoshi NAKAGAMI, Ryuichi MORISHITA