Patents by Inventor Marilee Burrell

Marilee Burrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMPLIFICATION OF HUMAN MDM2 GENE IN HUMAN TUMORS
    Publication number: 20080305490
    Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MD2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
    Type: Application
    Filed: July 1, 2008
    Publication date: December 11, 2008
    Applicant: The Johns Hopkins University
    Inventors: Marilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein
  • Antibody detection of mismatch repair proteins
    Patent number: 6048701
    Abstract: Antibodies directed to human protein mismatch repair proteins can be used diagnostically to discriminate between proliferating and non-proliferating cells. In addition, they can be used to determine whether cells have a mismatch repair defect caused by a mutation in e.g., hMSH2, hMLH1, or hPMS2. They can also be used to monitor the efficacy of anti-neoplastic therapies.
    Type: Grant
    Filed: September 9, 1996
    Date of Patent: April 11, 2000
    Assignee: The Johns Hopkins University
    Inventors: Kenneth W. Kinzler, Bert Vogelstein, Marilee Burrell, David E. Hill, Fredrick S. Leach
  • Methods for inhibiting interaction of human MDM2 and p53
    Patent number: 5858976
    Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: January 12, 1999
    Assignee: The Johns Hopkins University
    Inventors: Marilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein
  • Method of diagnosing Neoplastic disease by detecting increased expression of human MDM2 protein
    Patent number: 5736338
    Abstract: In certain human tumor cells, the gene encoding MDM2 protein is amplified and expression of MDM2 protein is elevated. Since human MDM2 protein binds to human p53, excess MDM2 protein apparently releases a cell from p53-regulated growth. Detection of elevated amounts of human MDM2 protein thus can be used to diagnose neoplastic disease in a human.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: April 7, 1998
    Assignee: The Johns Hopkins University
    Inventors: Marilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein
  • Polypetides which bind to human MDM2
    Patent number: 5708136
    Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: January 13, 1998
    Assignee: The Johns Hopkins University
    Inventors: Marilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein
  • Antibodies for detection of human MDM2 protein
    Patent number: 5618921
    Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth. Antibodies to the human MDM2 protein and kits containing MDM2 specific antibodies are disclosed.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: April 8, 1997
    Assignee: The Johns Hopkins University
    Inventors: Marilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein
  • Kits for detecting amplification of human MDM2
    Patent number: 5606044
    Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
    Type: Grant
    Filed: February 17, 1995
    Date of Patent: February 25, 1997
    Assignee: The Johns Hopkins University
    Inventors: Marilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein
  • Amplification of human MDM2 gene in human tumors
    Patent number: 5420263
    Abstract: A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
    Type: Grant
    Filed: April 7, 1993
    Date of Patent: May 30, 1995
    Assignee: The Johns Hopkins University
    Inventors: Marilee Burrell, David E. Hill, Kenneth W. Kinzler, Bert Vogelstein