Patents by Inventor Marilyn de la Cruz

Marilyn de la Cruz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180118678
    Abstract: This invention relates to a hemifumarate salt of 1-(4- 1-[(E)-cyclohexyl-3-tritluoromethy 1-benzy loxyimino ]-ethy 1)-2-ethy1-benzy l)-azetidine-3-carboxy lie acid (Compound) to pharmaceutics compositions comprising this salt, to processes for forming this salt and to its use in medical treatment, addition, the present invention also relates to new polymorphic forms of the hemifumarate salt form of Compound I, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: October 31, 2017
    Publication date: May 3, 2018
    Inventors: Lech CISZEWSKI, Marilyn DE LA CRUZ, Piotr H. KARPINSKI, Michael MUTZ, Christian RIEGERT, Caspar VOGEL, Ricardo SCHNEEBERGER
  • Patent number: 9181215
    Abstract: The invention relates to new crystalline forms of processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: November 10, 2015
    Assignee: Novartis AG
    Inventors: Marilyn De La Cruz, Piotr H. Karpinski, Liladhar Murlidhar Waykole
  • Publication number: 20150175536
    Abstract: This invention relates to a hemifumarate salt of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of the hemifumarate salt form of Compound I, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: March 3, 2015
    Publication date: June 25, 2015
    Inventors: Lech CISZEWSKI, Marilyn DE LA CRUZ, Piotr H. KARPINSKI, Michael MUTZ, Christian RIEGERT, Caspar VOGEL, Ricardo SCHNEEBERGER
  • Patent number: 8697682
    Abstract: This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: April 15, 2014
    Assignee: Novartis AG
    Inventors: Marilyn De La Cruz, Piotr H. Karpinski, Yugang Liu
  • Publication number: 20140005162
    Abstract: This invention relates to a hemifumarate salt of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzylyazetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of the hemifumarate salt form of Compound I, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: June 12, 2013
    Publication date: January 2, 2014
    Inventors: Lech CISZEWSKI, Marilyn DE LA CRUZ, Piotr H. KARPINSKI, Michael MUTZ, Christian RIEGERT, Caspar VOGEL, Ricardo SCHNEEBERGER
  • Publication number: 20130225571
    Abstract: The invention relates to new crystalline forms of processes for manufacturing a compound of formula 5, or a stereoisomer, tautomer or a salt thereof, wherein the substituents are as defined in the specification. The invention further relates to new manufacturing processes for specific solid forms of Compound A and its salts, to such solid forms and to use of said solid forms for the therapeutic treatment of warm-blooded animals.
    Type: Application
    Filed: September 29, 2011
    Publication date: August 29, 2013
    Applicant: NOVARTIS AG
    Inventors: John Vincent Calienni, Marilyn De La Cruz, Dietmar Flubacher, Baoqing Gong, Prasad Koteswara Kapa, Piotr H. Karpinski, Hui Liu, Pascal Michel, Rasmus Mose, Maria Caterina Testa, Liladhar Murlidhar Waykole
  • Publication number: 20130225550
    Abstract: This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: April 3, 2013
    Publication date: August 29, 2013
    Inventors: Marilyn DE LA CRUZ, Piotr H. KARPINSKI, Yugang LIU
  • Patent number: 8486930
    Abstract: This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: July 16, 2013
    Assignee: Novartis AG
    Inventors: Marilyn De La Cruz, Piotr H. Karpinski, Yugang Liu
  • Publication number: 20120214810
    Abstract: Salts of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4?-(trifluoromethoxy)[1,1?-biphenyl]-3-carboxamide are prepared and characterized.
    Type: Application
    Filed: May 2, 2012
    Publication date: August 23, 2012
    Applicant: NOVARTIS AG
    Inventors: Joginder Singh Bajwa, Marilyn De La Cruz, Stephanie Kay Dodd, Liladhar Murlidhar Waykole, Raeann Wu
  • Publication number: 20120115840
    Abstract: This invention relates to a hemifumarate salt of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of the hemifumarate salt form of Compound I, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: December 16, 2009
    Publication date: May 10, 2012
    Inventors: Lech Ciszewski, Marilyn De La Cruz, Piotr H. Karpinski, Michael Mutz, Christian Riegert, Caspar Vogel, Ricardo Schneeberger
  • Publication number: 20120035174
    Abstract: Salts of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4?-(trifluoromethoxy)[1,1?-biphenyl]-3-carboxamide are prepared and characterized.
    Type: Application
    Filed: October 13, 2011
    Publication date: February 9, 2012
    Applicant: NOVARTIS AG
    Inventors: Joginder Singh Bajwa, Marilyn De La Cruz, Stephanie Kay Dodd, Liladhar Murlidhar Waykole, Raeann Wu
  • Patent number: 8063043
    Abstract: Salts of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4?-(trifluoromethoxy)[1,1?-biphenyl]-3-carboxamide are prepared and characterized.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: November 22, 2011
    Assignee: Novartis AG
    Inventors: Joginder Bajwa, Marilyn de la Cruz, Stephanie Kay Dodd, Liladhar Murlidhar Waykole, Raeann Wu
  • Publication number: 20110257150
    Abstract: This invention relates to a hydrochloride, malate, oxalate and tartrate salt forms of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic acid (Compound I), to pharmaceutical compositions comprising this salt, to processes for forming this salt and to its use in medical treatment. In addition, the present invention also relates to new polymorphic forms of each of these salts, as well as to pharmaceutical compositions comprising these polymorphic forms, to processes for obtaining them, and their use in medical treatment.
    Type: Application
    Filed: December 17, 2009
    Publication date: October 20, 2011
    Inventors: Marilyn De La Cruz, Piotr H. Karpinski, Yugang Liu
  • Publication number: 20110178085
    Abstract: Salts of N-[6-(cis-2,6-dimethylmorpholin-4-yl)pyridine-3-yl]-2-methyl-4?-(trifluoromethoxy)[1,1?-biphenyl]-3-carboxamide are prepared and characterized.
    Type: Application
    Filed: September 15, 2009
    Publication date: July 21, 2011
    Applicant: NOVARTIS AG
    Inventors: Joginder Singh Bajwa, Marilyn de la Cruz, Stephanie Kay Dodd, Liladhar Murlidhar Waykole, Raeann Wu
  • Publication number: 20090143469
    Abstract: The present invention relates to salts of organic acid, in particular salt of nateglinide, combined preparations comprising one or more salts of nateglinide and, optionally, one or more additional ingredients and the use thereof in pharmaceutical compositions for preventing or treating diabetes, cardiovascular disease, or conditions associated therewith.
    Type: Application
    Filed: February 6, 2009
    Publication date: June 4, 2009
    Inventors: Paul Allen Sutton, Richard V. Vivilecchia, David John Parker, Marilyn De La Cruz
  • Publication number: 20050234129
    Abstract: The present invention relates to salts of organic acid, in particular salt of nateglinide, combined preparations comprising one or more salts of nateglinide and, optionally, one or more additional ingredients and the use thereof in pharmaceutical compositions for preventing or treating diabetes, cardiovascular diseases, or conditions associated therewith.
    Type: Application
    Filed: March 10, 2003
    Publication date: October 20, 2005
    Inventors: Paul Sutton, Richard Vivilecchia, David Parker, Marilyn De La Cruz