Patents by Inventor Marilyn Menger

Marilyn Menger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Efficient purification of adenovirus
    Patent number: 7141406
    Abstract: A method of enriching a solution for an adenovirus comprising contacting a solution containing an adenovirus with an anion exchange chromatography resin comprising an acrylate or sulphonamide linker such that the adenovirus binds to the chromatography resin and eluting the adenovirus from the resin with an eluant to obtain an enriched solution of adenovirus.
    Type: Grant
    Filed: May 5, 2003
    Date of Patent: November 28, 2006
    Assignee: GenVec, Inc.
    Inventors: Miguel E Carrion, Marilyn Menger, Imre Kovesdi
  • Efficient purification of adenovirus
    Publication number: 20030203469
    Abstract: A method of enriching a solution for an adenovirus comprising contacting a solution containing an adenovirus with an anion exchange chromatography resin comprising an acrylate or sulphonamide linker such that the adenovirus binds to the chromatography resin and eluting the adenovirus from the resin with an eluant to obtain an enriched solution of adenovirus.
    Type: Application
    Filed: May 5, 2003
    Publication date: October 30, 2003
    Applicant: GenVec, Inc.
    Inventors: Miguel E. Carrion, Marilyn Menger, Imre Kovesdi
  • Fluorescence detection
    Patent number: 6630299
    Abstract: The present invention provides methods of detecting and/or characterizing the viral vector particle content of a medium. A medium is provided and contacted with an excitation energy such that, if a viral vector particle is in the medium, an electron associated with the intrinsically fluorogenic portion of the viral vector particle will be raised to an excited energy state. The excited electron is permitted to emit radiation having an emission wavelength which is detected. The viral vector particle content of the medium then can be evaluated by comparing the detected emission wavelength with a standard signal. For example, the number of viral vector particles in a medium can be quantified by comparing the detected wavelength and its corresponding intensity to a standard signal. Similar methods for evaluating the adenoviral vector particle content of a medium and the intrinsically fluorogenic adenoviral structural protein content of a medium are provided.
    Type: Grant
    Filed: June 25, 2001
    Date of Patent: October 7, 2003
    Assignee: GenVec, Inc.
    Inventors: Miguel E. Carrión, Marilyn Menger
  • Efficient purification of adenovirus
    Patent number: 6586226
    Abstract: A method of enriching a solution of an adenovirus comprising applying a mixed solution comprising an adenovirus and at least one undesired type of biomolecule to an anion exchange chromatography resin containing a binding moiety selected from the group consisting of dimethylaminopropyl, dimethylaminobutyl, dimethylaminoisobutyl, and dimethylaminopentyl and eluting the adenovirus from the chromatography resin. Also provided is a method of purifying an adenovirus from adenovirus-infected cells comprising lysing such cells, applying the lysate to a single chromatography resin, eluting the adenovirus from the chromatography resin, and collecting a fraction containing adenovirus that is substantially as pure as triple CsCl density gradient-purified adenovirus.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: July 1, 2003
    Assignee: GenVec, Inc.
    Inventors: Miguel E. Carrión, Marilyn Menger, Imre Kovesdi
  • Utilizing intrinsic fluorescence to detect adenovirus
    Patent number: 6447995
    Abstract: The present invention provides methods of detecting and/or characterizing the viral vector particle content of a medium. A medium is provided and contacted with an excitation energy such that, if a viral vector particle is in the medium, an electron associated with the intrinsically fluorogenic portion of the viral vector particle will be raised to an excited energy state. The excited electron is permitted to emit radiation having an emission wavelength which is detected. The viral vector particle content of the medium then can be evaluated by comparing the detected emission wavelength with a standard signal. For example, the number of viral vector particles in a medium can be quantified by comparing the detected wavelength and its corresponding intensity to a standard signal. Similar methods for evaluating the adenoviral vector particle content of a medium and the intrinsically fluorogenic adenoviral structural protein content of a medium are provided.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: September 10, 2002
    Assignee: GenVec, Inc.
    Inventors: Miguel E. Carrión, Marilyn Menger
  • Efficient purification of adenovirus
    Patent number: 6383795
    Abstract: A method of enriching a solution of an adenovirus comprising applying a mixed solution comprising an adenovirus and at least one undesired type of biomolecule to an anion exchange chromatography resin containing a binding moiety selected from the group consisting of dimethylaminopropyl, dimethylaminobutyl, dimethylaminoisobutyl, and dimethylaminopentyl and eluting the adenovirus from the chromatography resin. Also provided is a method of purifying an adenovirus from adenovirus-infected cells comprising lysing such cells, applying the lysate to a single chromatography resin, eluting the adenovirus from the chromatography resin, and collecting a fraction containing adenovirus that is substantially as pure as triple CsCl density gradient-purified adenovirus.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: May 7, 2002
    Assignee: GenVec, Inc.
    Inventors: Miguel E. Carrión, Marilyn Menger, Imre Kovesdi
  • Efficient purification of adenovirus
    Publication number: 20020034735
    Abstract: A method of enriching a solution of an adenovirus comprising applying a mixed solution comprising an adenovirus and at least one undesired type of biomolecule to an anion exchange chromatography resin containing a binding moiety selected from the group consisting of dimethylaminopropyl, dimethylaminobutyl, dimethylaminoisobutyl, and dimethylaminopentyl and eluting the adenovirus from the chromatography resin. Also provided is a method of purifying an adenovirus from adenovirus-infected cells comprising lysing such cells, applying the lysate to a single chromatography resin, eluting the adenovirus from the chromatography resin, and collecting a fraction containing adenovirus that is substantially as pure as triple CsCl density gradient-purified adenovirus.
    Type: Application
    Filed: November 30, 2001
    Publication date: March 21, 2002
    Applicant: GenVec, Inc.
    Inventors: Miguel E. Carrion, Marilyn Menger, Imre Kovesdi