Patents by Inventor Marilyne Blain

Marilyne Blain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Constructs for enhancement of gene expression in muscle
    Patent number: 9217020
    Abstract: Efficient and muscle-specific gene expression can be obtained with constructs containing two or more copies of USE and/or ?USE fused to the minimal promoter of the TnISlow gene. USE is a small (about 160-bp) upstream enhancer of the TnISlow gene that confers slow-twitch muscle fiber specificity. ?USE is generated from a 100-bp deletion at the 5? end of USE. ?USE confers expression in slow- and fast-twitch muscle fibers. The strength and relatively small size (less than 600-bp) of these constructs make them useful for gene therapy applications.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: December 22, 2015
    Assignee: National Research Council of Canada
    Inventors: Marilyne Blain, Bernard Massie, Renald Gilbert
  • CONSTRUCTS FOR ENHANCEMENT OF GENE EXPRESSION IN MUSCLE
    Publication number: 20120282695
    Abstract: Efficient and muscle-specific gene expression can be obtained with constructs containing two or more copies of USE and/or ?USE fused to the minimal promoter of the TnISlow gene. USE is a small (about 160-bp) upstream enhancer of the TnISlow gene that confers slow-twitch muscle fiber specificity. ?USE is generated from a 100-bp deletion at the 5? end of USE. ?USE confers expression in slow- and fast-twitch muscle fibers. The strength and relatively small size (less than 600-bp) of these constructs make them useful for gene therapy applications.
    Type: Application
    Filed: April 14, 2008
    Publication date: November 8, 2012
    Inventors: Marilyne Blain, Bernard Massie, Renald Gilbert