Abstract: Disclosed are various examples and embodiments of systems, devices, components and methods configured to calculate the information content of data and information, which in some embodiments are based on new metrics integrating the real space and Fourier space properties of the data or information collected. Among other things, these systems, devices, components and methods provide an assessment of a full information collection chain; the information content of data in a harvesting experiment; global and local resolution; and the information content within objects of interest. Information and data metrics are measured in “bits”. The disclosed systems, devices, components and methods fall within the fields of information processing, information theory, digital signal processing, image processing, image analysis, channel capacity, signal transducers, and analogous fields, and include within their scope computing devices exploiting the new signal processing techniques and algorithms.