Abstract: A system for managing administration of prescribed medications to patients is disclosed. The system includes a server for receiving prescription fill requests which are based on prescriptions for the prescribed medications, and for causing uniquely identifiable medication packages to be produced based on the prescription fill requests and in conformity with the prescriptions. Each medication package contains a single dose of at least one of the prescribed medications. The server is further for receiving and maintaining medication package records specifying the contents of each particular medication package. The system includes an interface for providing access to the prescriptions and the medication package records for validating administration of the prescribed medications to the patients.