Patents by Inventor Marina Sirota
Marina Sirota has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240122885Abstract: Provided are methods of modulating gene expression levels in an individual identified as having endometriosis. The methods comprise administering to the individual identified as having endometriosis a drug described herein in an amount effective to modulate gene expression levels in the individual. Also provided are pharmaceutical compositions. The compositions comprise a drug described herein in an amount effective to modulate gene expression levels in an individual, wherein the pharmaceutical composition is adapted for intrauterine or intravaginal administration of the drug to the individual. Kits that find use in practicing the methods of the present disclosure are also provided. In some embodiments, the kits comprise a pharmaceutical composition comprising a drug described herein in an amount effective to modulate gene expression levels in the individual, and instructions for administering the pharmaceutical composition to an individual identified as having endometriosis.Type: ApplicationFiled: February 11, 2022Publication date: April 18, 2024Inventors: Marina Sirota, Linda Giudice, Arohee Bhoja, Daniel Bunis
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Publication number: 20230298696Abstract: The disclosure generally relates to methods of selecting a biomarker associated with a disorder or disease, and computer program products and systems for performing such methods. The disclosure further relates to biomarkers for rheumatoid arthritis and methods of use such biomarkers.Type: ApplicationFiled: July 23, 2021Publication date: September 21, 2023Inventors: Marina SIROTA, Dmitry RYCHKOV
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Patent number: 11754552Abstract: Methods of assessing a graft recipient's predisposition to reject a transplant are provided. The risk of transplant rejection may be assessed in a subject prior to transplant, wherein subjects having a greater immune repertoire diversity prior to transplant are more susceptible to transplant rejection. Also, increases in immune repertoire diversity after transplant are indicative of transplant risk after. In another aspect, the presence or elevated abundance of immune elements comprising IGHV3-23 sequences are indicators of transplant rejection risk. In another aspect the scope of the invention encompasses methods of treating transplant rejection in a subject, by assessing transplant risk and administering immunosuppressive therapy in accordance with assessed risk.Type: GrantFiled: June 11, 2018Date of Patent: September 12, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Minnie Sarwal, Marina Sirota, Silvia Pineda San Juan
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Patent number: 11713487Abstract: In the field of transplant rejection, identified are SNPs wherein mismatches in variants present in a recipient and donor for such SNPs are predictive of transplant outcome, wherein the SNPs represent non-HLA loci newly implicated in rejection. By the invention, transplant outcomes such as elevated risk of antibody mediated rejection, elevated risk of T-cell mediated rejection, or low risk of rejection can be predicted by analyzing mismatches between donor and recipient for the enumerated SNPs. Certain SNPs enumerated are predictive of kidney transplant outcome. The compatibility of prospective donors can be assessed for a recipient, allowing for optimized donor-recipient pairing.Type: GrantFiled: July 16, 2018Date of Patent: August 1, 2023Assignee: The Regents of the University of CaliforniaInventors: Minnie Sarwal, Marina Sirota, Silvia San Juan Pineda
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Publication number: 20220347135Abstract: Spontaneous preterm birth (sPTB) is premature delivery prior to 37 weeks of pregnancy and is a leading cause of infant mortality worldwide. sPTB is associated with a unique gene expression profile. Identified herein are numerous safe and proven therapeutic compositions used for unrelated indications that have the biological effect of reversing, in part, the gene expression profile of sPTB and which can be used in preventative or interventional treatments to prevent, delay, or ameliorate sPTB. The repurposed drugs include several Class A and Class B therapeutics that are regarded as safe or low risk in pregnant subjects.Type: ApplicationFiled: March 20, 2020Publication date: November 3, 2022Applicants: The Regents of the University of California, The Leland Stanford Junior UniversityInventors: Marina Sirota, Brian Le, Ronald Wong, David Stevenson
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Publication number: 20210238681Abstract: Disclosed are novel methods of assessing transplant rejection status in a transplant recipient, such as a kidney transplant recipient. The diagnostic method identifies stable subjects, subjects undergoing cell mediated rejection processes, and subjects undergoing antibody mediated rejection processes using measurement of TCR subunit repertoire diversity. The proportion of unique TCR alpha and beta subunit sequences to total unique TCR subunit sequences (total sequences for alpha, beta, delta, and gamma subunits) provides a diagnostic measure that can identify stable subjects, subjects undergoing cell mediated rejection processes, and subjects undergoing antibody mediated rejection processes. Methods of treatment include administration of a suitable treatment if antibody mediated rejection or cell mediated rejection is detected.Type: ApplicationFiled: March 12, 2019Publication date: August 5, 2021Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Minnie Sarwal, Marina Sirota, Silvia Pineda San Juan
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Publication number: 20210228519Abstract: The present disclosure provides methods of treating Alzheimer's Disease (AD) and rescuing cognitive deficits associated with AD in a subject having an apoE4/4 genotype, by administering a therapeutically effective amount of the loop-diuretic bumetanide to the subject. Also disclosed are kits for performing the method, including one or more doses of a bumetanide formulation; and which may also include instructions for treating a patient having an apoE4/4 genotype by administering bumetanide, and/or instructions and reagents for testing/identifying a subject having an apoE4/4 genotype.Type: ApplicationFiled: April 12, 2019Publication date: July 29, 2021Inventors: Yadong Huang, Alice Taubes, Phil Nova, Marina Sirota
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Publication number: 20200224271Abstract: In the field of transplant rejection, identified are SNPs wherein mismatches in variants present in a recipient and donor for such SNPs are predictive of transplant outcome, wherein the SNPs represent non-HLA loci newly implicated in rejection. By the invention, transplant outcomes such as elevated risk of antibody mediated rejection, elevated risk of T-cell mediated rejection, or low risk of rejection can be predicted by analyzing mismatches between donor and recipient for the enumerated SNPs. Certain SNPs enumerated are predictive of kidney transplant outcome. The compatibility of prospective donors can be assessed for a recipient, allowing for optimized donor-recipient pairing.Type: ApplicationFiled: July 16, 2018Publication date: July 16, 2020Applicant: The Regents of the University of CaliforniaInventors: Minnie Sarwal, Marina Sirota, Silvia San Juan Pineda
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Publication number: 20180356403Abstract: Methods of assessing a graft recipient's predisposition to reject a transplant are provided. The risk of transplant rejection may be assessed in a subject prior to transplant, wherein subjects having a greater immune repertoire diversity prior to transplant are more susceptible to transplant rejection. Also, increases in immune repertoire diversity after transplant are indicative of transplant risk after. In another aspect, the presence or elevated abundance of immune elements comprising IGHV3-23 sequences are indicators of transplant rejection risk. In another aspect the scope of the invention encompasses methods of treating transplant rejection in a subject, by assessing transplant risk and administering immunosuppressive therapy in accordance with assessed risk.Type: ApplicationFiled: June 11, 2018Publication date: December 13, 2018Inventors: Minnie Sarwal, Marina Sirota, Silvia Pineda San Juan
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Patent number: 10149783Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patentcy of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: GrantFiled: February 22, 2016Date of Patent: December 11, 2018Assignee: Somnics, Inc.Inventors: Chung-Chu Chen, Ching Shang, Marina Sirota, Zhen Yao
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Patent number: 9387117Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patency of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: GrantFiled: September 27, 2010Date of Patent: July 12, 2016Assignee: Somnics, Inc.Inventors: Chung-Chu Chen, Ching Shang, Marina Sirota, Zhen Yao
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Publication number: 20160166425Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patentcy of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: ApplicationFiled: February 22, 2016Publication date: June 16, 2016Inventors: Chung-Chu Chen, Ching Shang, Marina Sirota, Zhen Yao
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Patent number: 9138342Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection to mouth and prevents disengaging from patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft tissue in a forward direction, the patency of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth preventing air from entering the oral cavity from atmosphere. The negative pressure will also pull the soft palate into contact with the rear surface of the tongue to create a seal that prevents the air from entering the oral cavity through the nasal airway.Type: GrantFiled: October 15, 2013Date of Patent: September 22, 2015Assignee: SOMNICS, INC.Inventors: Chung-Chu Chen, Marina Sirota
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Publication number: 20140041668Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection to mouth and prevents disengaging from patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft tissue in a forward direction, the patency of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth preventing air from entering the oral cavity from atmosphere. The negative pressure will also pull the soft palate into contact with the rear surface of the tongue to create a seal that prevents the air from entering the oral cavity through the nasal airway.Type: ApplicationFiled: October 15, 2013Publication date: February 13, 2014Applicant: SOMNICS, INC.Inventors: CHUNG-CHU CHEN, MARINA SIROTA
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Patent number: 8567406Abstract: An oral apparatus and a method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity are provided. The mini oral interface creates a secure connection to mouth and prevents disengaging from patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward. By moving the tongue and the soft tissue in a forward direction, the patency of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth preventing air from entering the oral cavity from atmosphere. The negative pressure will also pull the soft palate into contact with the rear surface of the tongue to create a seal that prevents the air from entering the oral cavity through the nasal airway.Type: GrantFiled: January 24, 2011Date of Patent: October 29, 2013Assignee: Somnics, Inc.Inventors: Chung-Chu Chen, Marina Sirota
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Publication number: 20110180075Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection to mouth and prevents disengaging from patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft tissue in a forward direction, the patency of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth preventing air from entering the oral cavity from atmosphere. The negative pressure will also pull the soft palate into contact with the rear surface of the tongue to create a seal that prevents the air from entering the oral cavity through the nasal airway.Type: ApplicationFiled: January 24, 2011Publication date: July 28, 2011Applicant: SOMNICS, INC.Inventors: Chung-Chu CHEN, Marina SIROTA
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Publication number: 20110073119Abstract: This invention provides an oral apparatus and method capable of alleviating or curing snore and obstructive sleep apnea by applying a negative pressure through a mini oral interface to the oral cavity. The mini oral interface creates a secure connection between the interface and mouth or teeth and prevents the interface from falling off. The oral interface also provides fixation between upper and lower lips (or tooth) and prevents opening of patient's mouth during sleeping. The negative pressure pulls the tongue toward upper palate and also pulls the soft palate forward as well. By moving the tongue and the soft palate in a forward direction, the patentcy of the upper airway near the pharynx is maintained to prevent sleep-disordered breathing. The negative pressure will pull the lips inward to close the mouth ad prevent air from entering the oral cavity from atmosphere.Type: ApplicationFiled: September 27, 2010Publication date: March 31, 2011Applicant: SOMNICS, INC.Inventors: Chung-Chu CHEN, Ching SHANG, Marina SIROTA, Zhen YAO
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Patent number: 7507683Abstract: A glass-ceramic material, particularly for elements in laser systems, and a method for preparing same. The glass-ceramic material may be used for an optical fiber for communication systems and laser systems. The glass-ceramic may include gahnite crystals and optionally ?-quartz-like solid solution, or a petalite-like crystals, spinel, and zirconia crystals. The elements may comprise a host material glass-ceramic, where the glass-ceramic is doped with appropriate ions.Type: GrantFiled: September 21, 2007Date of Patent: March 24, 2009Assignee: Elop Electro-Optics Industries Ltd.Inventors: Marina Sirota, Ehud Galun, Adrian Goldshtein, Alla Buch, Vladimir Krupkin, Rami Cohen, Alexander Glushko, Elena Luria
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Patent number: 7466727Abstract: A passive Q-switch for a laser system, and a method for its production. The laser is operative at near infrared wavelength region, including the eye-safe region. The Q-switch includes a saturable absorber based on IV-VI semiconductor nanocrystals (NCs), embedded in a polymer matrix. The NCs preferably include lead selenide, lead sulfide, or lead selenide sulfide. The NCs may be surface passivated, and may feature a PbSe/PbS core-shell configuration.Type: GrantFiled: October 16, 2006Date of Patent: December 16, 2008Assignees: ELOP Electro-Optics Industries Ltd., Technion Research and Development Foundation Ltd.Inventors: Ehud Galun, Efrat Lifshitz, Marina Sirota, Vladimir Krupkin, Aldona Sashchiuk
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Publication number: 20080207425Abstract: A glass-ceramic material, particularly for elements in laser systems, and a method for preparing same. The glass-ceramic material may be used for an optical fiber for communication systems and laser systems. The glass-ceramic may include gahnite crystals and optionally ?-quartz-like solid solution, or a petalite-like crystals, spinel, and zirconia crystals. The elements may comprise a host material glass-ceramic, where the glass-ceramic is doped with appropriate ions.Type: ApplicationFiled: September 21, 2007Publication date: August 28, 2008Applicant: ELOP ELECTRO-OPTICS INDUSTRIES LTD.Inventors: Marina Sirota, Ehud Galun, Adrian Goldshtein, Alla Buch, Vladimir Krupkin, Rami Cohen, Alexander Glushko, Elena Luria