Patents by Inventor Marina Virgili Bernadó

Marina Virgili Bernadó has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Patent number: 11649248
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: May 16, 2023
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carmen Almansa-Rosales, Carlos Alegret-Molina
  • OXADIAZASPIRO COMPOUNDS FOR THE TREATMENT OF DRUG ABUSE AND ADDICTION
    Publication number: 20210115062
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazespiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Application
    Filed: December 21, 2020
    Publication date: April 22, 2021
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Carlos ALEGRET-MOLINA
  • Quinoline and isoquinoline derivatives for treating pain and pain related conditions
    Patent number: 10941138
    Abstract: The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: March 9, 2021
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Carmen Almansa-Rosales, Susana Yenes-Mínguez, Marina Virgili-Bernado, Monica Alonso-Xalma
  • Oxadiazaspiro compounds for the treatment of drug abuse and addiction
    Patent number: 10927128
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: February 23, 2021
    Assignee: ESTEVE PHARMACEUTICALS. S.A.
    Inventors: Marina Virgili-Bernado, Carmen Almansa-Rosales, Carlos Alegret-Molina
  • ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200339597
    Abstract: The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 18, 2020
    Publication date: October 29, 2020
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia Lopez
  • Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10703765
    Abstract: The present invention relates to compounds of general formula (I) having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: July 7, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia Lopez
  • NEW PROPANAMINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20200207759
    Abstract: The present invention relates to new compounds of general formula (I) that show dual activity towards ?2? subunit of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit, and to the noradrenallne transporter (NET). The invention is also related to the process for the preparation of said compounds as well as to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: July 27, 2018
    Publication date: July 2, 2020
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Monica ALONSO-XALMA, Laura OSORIO-PLANES
  • OXA-Diazaspiro compounds having activity against pain
    Patent number: 10689398
    Abstract: The present invention relates to oxa-diazaspiro compounds having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: June 23, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carmen Almansa-Rosales, Carlos Alegret-Molina
  • META SUBSTITUTED PHENYLPYRAZOLO- AND PHENYLPYRROLO- PYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200190081
    Abstract: The present invention relates to meta substituted phenylpyrazolo- and phenylpyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the NET receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 30, 2017
    Publication date: June 18, 2020
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carmen ALMANSA-ROSALES, José-Luis DÍAZ-FERNÁNDEZ
  • NEW QUINOLINE AND ISOQUINOLINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20200087291
    Abstract: The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).
    Type: Application
    Filed: December 20, 2017
    Publication date: March 19, 2020
    Inventors: Carmen ALMANSA-ROSALES, Susana YENES-MÍNGUEZ, Marina VIRGILI-BERNADO, Monica ALONSO-XALMA
  • Ortho substituted phenylpyrazolo- and phenylpyrrolo-pyridazine derivatives having multimodal activity against pain
    Patent number: 10562908
    Abstract: The present invention relates to ortho substituted phenylpyrazolo- and pyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: February 18, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carmen Almansa-Rosales
  • NITROGEN CONTAINING BICYCLIC DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS
    Publication number: 20190345146
    Abstract: The present invention relates to new compounds of formula (I): showing great affinity and activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels or dual activity towards the subunit ?2? of voltage-gated calcium channels (VGCC), especially the ?2?-1 subunit of voltage-gated calcium channels, and the noradrenaline transporter (NET).
    Type: Application
    Filed: December 20, 2017
    Publication date: November 14, 2019
    Inventors: Carmen ALMANSA-ROSALES, Marina VIRGILI-BERNADO, Monica ALONSO-XALMA
  • Substituted morpholine derivatives having activity against pain
    Patent number: 10421750
    Abstract: The present invention relates to substituted morpholine derivatives having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: September 24, 2019
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Marina Virgili-Bernado, Carlos Alegret-Molina
  • ORTHO SUBSTITUTED PHENYLPYRAZOLO- AND PHENYLPYRROLO-PYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20190284195
    Abstract: The present invention relates to ortho substituted phenylpyrazolo- and pyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 30, 2017
    Publication date: September 19, 2019
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carmen ALMANSA-ROSALES
  • Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Publication number: 20190177337
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: February 14, 2019
    Publication date: June 13, 2019
    Inventors: Marina VIRGILI-BERNADO, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia-Lopez
  • Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10246465
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opioid receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: April 2, 2019
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Monica Garcia Lopez
  • OXA-DIAZASPIRO COMPOUNDS HAVING ACTIVITY AGAINST PAIN
    Publication number: 20190002475
    Abstract: The present invention relates to oxa-diazaspiro compounds having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 21, 2016
    Publication date: January 3, 2019
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Carlos ALEGRET-MOLINA
  • OXADIAZASPIRO COMPOUNDS FOR THE TREATMENT OF DRUG ABUSE AND ADDICTION
    Publication number: 20180327422
    Abstract: The present invention relates to compounds having pharmacological activity towards the sigma (?) receptor, and more particularly to oxadiazaspiro compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular against drug abuse and addiction.
    Type: Application
    Filed: November 15, 2016
    Publication date: November 15, 2018
    Inventors: Marina VIRGILI-BERNADO, Carmen ALMANSA-ROSALES, Carlos ALEGRET-MOLINA
  • SUBSTITUTED MORPHOLINE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
    Publication number: 20180305343
    Abstract: The present invention relates to substituted morpholine derivatives having pharmacological activity towards the sigma (?) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 25, 2018
    Applicant: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Marina VIRGILI-BERNADO, Carlos ALEGRET-MOLINA
  • Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
    Patent number: 10065971
    Abstract: The present invention relates to compounds having dual pharmacological activity towards both the sigma (?) receptor, and the ?-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. wherein Y is n is 1 or 2; q is 1, 2, 3, 4, 5 or 6; X is a bond, —C(O)O—, —C(O)NR8—, —C(O)—, —O— or —C(R4R4?)—; R1 is C(O)R5 or S(O)2R5.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 4, 2018
    Assignee: ESTEVE PHARMACEUTICALS S.A.
    Inventors: Marina Virgili-Bernado, Monica Alonso-Xalma, Carlos Alegret-Molina, Carmen Almansa-Rosales, Ramón Merce-Vidal