Patents by Inventor Marinee Chuah

Marinee Chuah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liver-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof
    Publication number: 20230293728
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Application
    Filed: April 14, 2023
    Publication date: September 21, 2023
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
  • Liver-specific nucleic acid regulatory elements and methods and use thereof
    Patent number: 11654201
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Grant
    Filed: October 21, 2019
    Date of Patent: May 23, 2023
    Assignees: VIB VZW, Universiteit Gent, Life Sciences Research Partners VZW
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
  • Endothelium-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof
    Publication number: 20230051499
    Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance endothelial cell-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly endothelial cell-directed gene therapy, and for vaccination purposes.
    Type: Application
    Filed: July 26, 2022
    Publication date: February 16, 2023
    Inventors: Marinee Chuah, Thierry Vandendriessche
  • Vectors for Liver-Directed Gene Therapy of Hemophilia and Methods and Use Thereof
    Publication number: 20230022390
    Abstract: The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Application
    Filed: July 15, 2022
    Publication date: January 26, 2023
    Inventors: Thierry Vandendriessche, Marinee Chuah
  • Endothelium-specific nucleic acid regulatory elements and methods and use thereof
    Patent number: 11446375
    Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance endothelial cell-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly endothelial cell-directed gene therapy, and for vaccination purposes.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 20, 2022
    Assignee: Vrije Universiteit Brussel
    Inventors: Marinee Chuah, Thierry Vandendriessche
  • Vectors for liver-directed gene therapy of hemophilia and methods and use thereof
    Patent number: 11419950
    Abstract: The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: August 23, 2022
    Assignee: Vrije Universiteit Brussel
    Inventors: Thierry Vandendriessche, Marinee Chuah
  • Muscle-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof
    Publication number: 20210395770
    Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly muscle-directed gene therapy, and for vaccination purposes.
    Type: Application
    Filed: June 9, 2021
    Publication date: December 23, 2021
    Inventors: Thierry Vandendriessche, Marinee Chuah, Pieter De Bleser
  • Optimized Liver-Specific Expression Systems for FVIII and FIX
    Publication number: 20210369868
    Abstract: The present invention relates to nucleic acid expression cassettes and vectors containing liver-specific regulatory elements and codon-optimized factor IX or factor VIII transgenes, methods employing these expression cassettes and vectors and uses thereof. The present invention is particularly useful for applications using liver-directed gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Application
    Filed: April 26, 2021
    Publication date: December 2, 2021
    Inventors: Marinee Chuah, Thierry Vandendriessche
  • Muscle-specific nucleic acid regulatory elements and methods and use thereof
    Patent number: 11072801
    Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly muscle-directed gene therapy, and for vaccination purposes.
    Type: Grant
    Filed: January 21, 2015
    Date of Patent: July 27, 2021
    Assignees: VRIJE Universiteit Brussel, VIB VZW, Universiteit Gent
    Inventors: Thierry Vandendriessche, Marinee Chuah, Pieter De Bleser
  • Optimized liver-specific expression systems for FVIII and FIX
    Patent number: 11007280
    Abstract: The present invention relates to nucleic acid expression cassettes and vectors containing liver-specific regulatory elements and codon-optimized factor IX or factor VIII transgenes, methods employing these expression cassettes and vectors and uses thereof. The present invention is particularly useful for applications using liver-directed gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: May 18, 2021
    Assignee: Vrije Universiteit Brussel
    Inventors: Marinee Chuah, Thierry Vandendriessche
  • Muscle-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof
    Publication number: 20200407746
    Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly muscle-directed gene therapy, and for vaccination purposes.
    Type: Application
    Filed: July 9, 2020
    Publication date: December 31, 2020
    Inventors: Thierry Vandendriessche, Marinee Chuah, Pieter De Bleser
  • Muscle-specific nucleic acid regulatory elements and methods and use thereof
    Patent number: 10731177
    Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly muscle-directed gene therapy, and for vaccination purposes.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: August 4, 2020
    Assignees: Vrije Universiteit Brussel, VIB VZW, Universiteit Gent
    Inventors: Thierry Vandendriessche, Marinee Chuah, Pieter De Bleser
  • Endothelium-Specific Nucleic Acid Regulatory Elements and Methods and Use Thereof
    Publication number: 20200237900
    Abstract: The present invention relates to nucleic acid regulatory elements that are able to enhance endothelial cell-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. The present invention is particularly useful for applications using gene therapy, more particularly endothelial cell-directed gene therapy, and for vaccination purposes.
    Type: Application
    Filed: December 22, 2016
    Publication date: July 30, 2020
    Inventors: Marinee Chuah, Thierry Vandendriessche
  • LIVER-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND USE THEREOF
    Publication number: 20200038522
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 6, 2020
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
  • Liver-specific nucleic acid regulatory elements and methods and use thereof
    Patent number: 10471157
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: November 12, 2019
    Assignees: VIB VZW, Universiteit Gent
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
  • Vectors for liver-directed gene therapy of hemophilia and methods and use thereof
    Patent number: 10398787
    Abstract: The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: September 3, 2019
    Assignee: Vrije Universiteit Brussel
    Inventors: Thierry Vandendriessche, Marinee Chuah
  • Vectors for Liver-Directed Gene Therapy of Hemophilia and Methods and Use Thereof
    Publication number: 20190240350
    Abstract: The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Application
    Filed: December 21, 2018
    Publication date: August 8, 2019
    Inventors: Thierry Vandendriessche, Marinee Chuah
  • LIVER-SPECIFIC NUCLEIC ACID REGULATORY ELEMENTS AND METHODS AND USE THEREOF
    Publication number: 20190046663
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Application
    Filed: October 30, 2018
    Publication date: February 14, 2019
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser
  • Vectors for liver-directed gene therapy of hemophilia and methods and use thereof
    Patent number: 10159753
    Abstract: The present invention relates to vectors containing liver-specific regulatory sequences and codon-optimized factor IX or factor VIII genes, methods employing these vectors and uses of these vectors. Expression cassettes and vectors containing these liver-specific regulatory elements and codon-optimized factor IX or factor VIII genes are also disclosed. The present invention is particularly useful for applications using gene therapy, in particular for the treatment of hemophilia A and B.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: December 25, 2018
    Assignee: Vrije Universiteit Brussel
    Inventors: Thierry Vandendriessche, Marinee Chuah
  • Liver-specific nucleic acid regulatory elements and methods and use thereof
    Patent number: 10149914
    Abstract: Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: December 11, 2018
    Assignees: VIB VZW, Life Sciences Research Partners VZW, Universiteit Gent
    Inventors: Marinee Chuah, Thierry Vandendriessche, Pieter De Bleser