Patents by Inventor Marinella Callow

Marinella Callow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphospecific PAK antibodies and diagnostic kits
    Publication number: 20050054017
    Abstract: The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is a method for determining a subset of a given population that is amenable to treatment with a compound that modulates PAK activity.
    Type: Application
    Filed: November 20, 2003
    Publication date: March 10, 2005
    Inventors: Tod Smeal, Marinella Callow, Bahija Jallal
  • Novel cell signaling polypeptides and nucleic acids
    Publication number: 20040072772
    Abstract: The present invention relates to an isolated SRK polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a protein kinase activity; an autophosphorylating activity; a cell survival promoting activity; a HAX-1 binding activity; an apoptosis suppression activity; a MAPKK stimulatory activity; a transcription modulatory activity, and a SRK-specific immunogenic activity. The invention relates to all aspects of SRK, or homologs thereof, including assays for modulators, activators, ligands, etc. The invention also relates to a cytolic or soluble HAX-1 which produces apoptosis when expressed in cells.
    Type: Application
    Filed: January 27, 2003
    Publication date: April 15, 2004
    Inventors: Rosamaria Ruggieri, Marinella Callow, Paul W. Diaz
  • Cell signaling polypeptides and nucleic acids
    Patent number: 6511825
    Abstract: The present invention relates to an isolated SRK polypeptide, biologically-active polypeptide fragments thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a protein kinase activity; an autophosphorylating activity; a cell survival promoting activity; a HAX-1 binding activity; an apoptosis suppression activity; a MAPKK stimulatory activity; a transcription modulatory activity, and a SRK-specific immunogenic activity. The invention relates to all aspects of SRK, or homologs thereof, including assays for modulators, activators, ligands, etc. The invention also relates to a cytolic or soluble HAX-1 which produces apoptosis when expressed in cells.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: January 28, 2003
    Assignee: Onyx Pharmaceuticals, Inc.
    Inventors: Rosamaria Ruggieri, Marinella Callow, Paul W. Diaz