Patents by Inventor Marintha Heil

Marintha Heil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR DETECTION OF MALARIA
    Publication number: 20240102110
    Abstract: Methods for the rapid detection of the presence or absence of Malaria parasites (including Plasmodium) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Additionally, the assay can be a multiplex assay, to amplify and detect a plurality of Plasmodium targets simultaneously, which offers advantages over singleplex assays. Furthermore, oligonucleotide primers and oligonucleotide probes targeting Malaria parasites (including Plasmodium) and kits are provided that are designed for the detection of Plasmodium, including, but not limited to, the Plasmodium species of P. falciparum, P. vivax, P. ovale, P. knowlesi, and P. malariae. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of Malaria parasites (including Plasmodium).
    Type: Application
    Filed: December 3, 2021
    Publication date: March 28, 2024
    Inventors: Sharon Ho-Chen Chiu, Yvonne Gicheru, Marintha Heil, Michael K. Lee, Chitra Manohar, Rochak Mehta, Ellen Ordinario, Jaya Rajamani, Jingtao Sun
  • Compositions and methods for amplification and detection of hepatitis B virus RNA, including HBV RNA transcribed from cccDNA
    Patent number: 11739382
    Abstract: Methods for the rapid detection of the presence or absence of Hepatitis B Virus (HBV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, competitive blocking oligonucleotides, and probes targeting HBV (in particular HBV RNA, in particular, HBV RNA transcribed from cccDNA, such as pgRNA) and kits are provided that are designed for the detection of HBV (in particular HBV RNA, in particular, HBV RNA transcribed from cccDNA, such as pgRNA).
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: August 29, 2023
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Jeffery Fong, Aaron T. Hamilton, Marintha Heil, Igor Kozlov, Ed Gustavo Marins, Elizabeth Marie Scott, Ling Wang
  • COMPOSITIONS AND METHODS FOR AMPLIFICATION AND DETECTION OF HEPATITIS B VIRUS RNA, INCLUDING HBV RNA TRANSCRIBED FROM cccDNA
    Publication number: 20220275465
    Abstract: Methods for the rapid detection of the presence or absence of Hepatitis B Virus (HBV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, competitive blocking oligonucleotides, and probes targeting HBV (in particular HBV RNA, in particular, HBV RNA transcribed from cccDNA, such as pgRNA) and kits are provided that are designed for the detection of HBV (in particular HBV RNA, in particular, HBV RNA transcribed from cccDNA, such as pgRNA).
    Type: Application
    Filed: January 28, 2022
    Publication date: September 1, 2022
    Inventors: Alan Blair, Jeffery Fong, Aaron T. Hamilton, Marintha Heil, Igor Kozlov, Ed Gustavo Marins, Elizabeth Marie Scott, Ling Wang
  • COMPOSITIONS AND METHODS FOR DETECTION OF EPSTEIN BARR VIRUS (EBV)
    Publication number: 20220251670
    Abstract: Methods for the rapid detection of the presence or absence of Epstein Barr Virus (EBV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting EBV, and kits are provided that are designed for the detection of target regions of EBV. Also described are kits, reaction mixtures, and oligonucleotides (e.g., primer and probe) for the amplification and detection of EBV. Also described are primers and probes that detect different regions of EBV, and can be employed in a dual target assay for simultaneously detecting two different and non-overlapping target regions of EBV.
    Type: Application
    Filed: July 24, 2020
    Publication date: August 11, 2022
    Inventors: Aaron T. Hamilton, Marintha Heil, Debra Liggett, Jingtao Sun, Ling Wang, Xiaoning Wu
  • Compositions and methods for detection of zika virus
    Patent number: 11155886
    Abstract: Methods for the rapid detection of the presence or absence of Zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Zika virus and kits are provided that are designed for the detection of Zika virus.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Slav Dugenny, Ellen H Fiss, Jeffery Fong, Marintha Heil, Eugene Spier, Jingtao Sun
  • COMPOSITIONS AND METHODS FOR DETECTING SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 (SARS-COV-2), INFLUENZA A AND INFLUENZA B
    Publication number: 20210285061
    Abstract: Methods for the rapid detection of the presence or absence of SARS-CoV-2, influenza A and influenza B in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting SARS-CoV-2, influenza A, and influenza B and kits are provided that are designed for the detection of SARS-CoV-2, influenza A and influenza B.
    Type: Application
    Filed: March 8, 2021
    Publication date: September 16, 2021
    Inventors: Chitra Manohar, Marcel R. Fontecha, Marintha Heil, Ramani Sadanandam Ravirala, Christopher David Santini, Eugene Spier, Jingtao Sun, Thanh Tam, Huan Truong, Michelle Elizabeth Yee, Kalyani Mangipudi
  • COMPOSITIONS AND METHODS FOR AMPLIFICATION AND DETECTION OF HEPATITIS B VIRUS RNA, INCLUDING HBV RNA TRANSCRIBED FROM cccDNA
    Publication number: 20210062259
    Abstract: Methods for the rapid detection of the presence or absence of Hepatitis B Virus (HBV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, competitive blocking oligonucleotides, and probes targeting HBV (in particular HBV RNA, in particular, HBV RNA transcribed from cccDNA, such as pgRNA) and kits are provided that are designed for the detection of HBV (in particular HBV RNA, in particular, HBV RNA transcribed from cccDNA, such as pgRNA).
    Type: Application
    Filed: February 24, 2020
    Publication date: March 4, 2021
    Inventors: Jeffery Fong, Aaron T. Hamilton, Marintha Heil, Igor Kozlov, Ed Gustavo Marins, Elizabeth Marie Scott, Ling Wang
  • COMPOSITIONS AND METHODS FOR DETECTION OF ZIKA VIRUS
    Publication number: 20200232051
    Abstract: Methods for the rapid detection of the presence or absence of Zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Zika virus and kits are provided that are designed for the detection of Zika virus.
    Type: Application
    Filed: April 6, 2020
    Publication date: July 23, 2020
    Inventors: Slav Dugenny, Ellen H Fiss, Jeffery Fong, Marintha Heil, Eugene Spier, Jingtao Sun
  • Compositions and methods for detection of Zika virus
    Patent number: 10655190
    Abstract: Methods for the rapid detection of the presence or absence of Zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Zika virus and kits are provided that are designed for the detection of Zika virus.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: May 19, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Slav Dugenny, Ellen H. Fiss, Jeffery Fong, Marintha Heil, Eugene Spier, Jingtao Sun
  • COMPOSITIONS AND METHODS FOR DETECTION OF ZIKA VIRUS
    Publication number: 20170260596
    Abstract: Methods for the rapid detection of the presence or absence of Zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Zika virus arid kits are provided that are designed for the detection of Zika virus.
    Type: Application
    Filed: March 10, 2017
    Publication date: September 14, 2017
    Inventors: Slav Dugenny, Ellen H. Fiss, Jeffery Fong, Marintha Heil, Eugene Spier, Jingtao Sun