Patents by Inventor MARINUS JOHANNES VAN HAPEREN

MARINUS JOHANNES VAN HAPEREN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody production
    Patent number: 11877565
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: January 23, 2024
    Assignee: ERASMUS UNIVERSITY MEDICAL CENTER
    Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
  • ANTIBODIES
    Publication number: 20220275059
    Abstract: The invention relates to antibodies and antigen-binding fragments thereof that recognize coronavirus spike proteins(CoV-S), such asthe spike protein of Middle East respiratory syndrome coronavirusspike protein(MERS-S). In some embodiments, the antibodiesbind to CoV-Swith high affinity, inhibit CoV infection of human cells, inhibit CoV sialic acid-binding activity and/or bind to multiple types of CoV-S. In some embodiments, the antibodies provide a means of preventing, treating or ameliorating CoV infection.
    Type: Application
    Filed: February 20, 2020
    Publication date: September 1, 2022
    Inventors: Franklin Gerardus GROSVELD, Marinus Johannes VAN HAPEREN, Dubravka DRABEK, Berend Jan BOSCH, Ivy WIDJAJA, Chunyan WANG, Brenda VAN DIEREN, Wentao LI, Frank J.M. VAN KUPPEVELD, Bart L. HAAGMANS, Nisreen M.A. OKBA
  • Antibody production
    Patent number: 9980470
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 29, 2018
    Assignee: Erasmus University Medical Center
    Inventors: Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen, Roger Kingdon Craig, Ernie De Boer
  • ANTIBODY PRODUCTION
    Publication number: 20160295842
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Application
    Filed: July 23, 2015
    Publication date: October 13, 2016
    Applicant: Erasmus University Medical Center
    Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
  • Antibody production
    Patent number: 9131669
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 15, 2015
    Assignee: ERASMUS UNIVERSITY MEDICAL CENTER
    Inventors: Roger Kingdon Craig, Franklin Gerardus Grosveld, Richard Wilhelm Janssens, Marinus Johannes Van Haperen
  • ANTIBODY PRODUCTION
    Publication number: 20140356907
    Abstract: A transgenic non-human mammal containing a heterologous lambda light chain gene locus, and/or a heterologous kappa light chain gene locus, and/or a heterologous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge.
    Type: Application
    Filed: March 14, 2014
    Publication date: December 4, 2014
    Applicant: ERASMUS UNIVERSITY MEDICAL CENTER
    Inventors: FRANKLIN GERARDUS GROSVELD, RICHARD WILHELM JANSSENS, MARINUS JOHANNES VAN HAPEREN, ROGER KINGDON CRAIG, ERNIE DE BOER