Abstract: Solid porous supports find use in array analysis, as they offer high surface area for contacting the analyzed sample. The present invention provides a solid porous support suitable for array analysis having first and second surfaces, and comprising channels extending from said first surface to said second surface, characterised in that at least one conductive material is applied to predefined regions on said first surface and/or on said second surface and/or inside the channels contained within said solid porous support. Such conductive material(s) may form a high-precision grid delineating physically distinct compartments within the support and thus reduce the risk of cross-contamination in array analysis. Additionally, such conductive material(s) may directly participate in reactions performed on the array by means of their electrical and/or thermal conductivity.

Abstract: A system for analyzing a blood sample comprises an element for nucleic acid (NA) isolation, an element for NA amplification, an incubator and a detector for detecting a parameter of the blood sample. The system comprises a single disposable cartridge having the NA isolation element and the NA amplification element, and a device having the incubator and the detector. The device is provided with a receiving space and each cartridge is adapted to be inserted into the receiving space. The NA amplification part of the cartridge is located within the incubator when the cartridge has been inserted into the receiving space.

Abstract: The present invention relates to elongated hollow tubular body for analysing an interaction between target and probe molecules, comprising a support with through going channels enabling flow through of liquids arranged at the open end, and a mouthpiece at the other end. In particular a flow-through array technology linked to a disposable in the form of a 0.1-1 ml standard pipet tip is provided. The device pre-spotted with a number of markers can be used in robotic/liquid handling system capable of handling disposable tips. The roboticaiquid handling system has the ability to perform all liquid handling steps through the syringes on the system including the binding of markers in the flow-through arrays. Furthermore all incubation steps can be performed on the platform which is equipped with an incubator device and an optical read-out device for analysing its signal.

Abstract: The present invention relates methods for screening of compounds for drug candidates comprising: (a) providing a solid porous support having first and second surfaces and at least one area with a plurality of through-going channels wherein said solid porous support comprises compounds within predefined regions of the said support; wherein said compounds within the porous structure are stored in dried condition, wherein said dried condition is obtained after a drying treatment by slow evaporation, vacuum drying or by blowing air or inert gas above and below said solid support; (b) providing a liquid sample comprising at least one molecular target; (c) mixing said dried compounds of step (a) with said liquid sample of step (b) by flow of the sample through said predefined regions of the solid support through the said through-going channels; (d) screening said compounds for drug candidates; said screening is by monitoring in an assay a compound-target interaction by measurement of a signal, said signal indicatin

Abstract: A system for conducting chemical and/or biochemical reactions is provided, comprising a reaction substrate (A) with a multiplicity of reactor zones (C), said reaction substrate (A) having a substantially flat top surface and a substantially flat bottom surface, the reaction substrate (A) being porous with a multiplicity of essentially parallel pores enabling liquid flow through, said pores having a diameter of about 10 ?m to 10 nm, characterised in that said flat top surface is bonded to the bottom of a first rigid support (B), said rigid support (B) comprising a multiplicity of through going holes extending from the top of said rigid support (B) to the bottom of said rigid support (B), and said through going holes defining the reactor zones (C). The invention further relates to the use of said system, an apparatus comprising said system as well as an incubation device for holding said system and a loading station.

Abstract: The present invention relates to methods for monitoring interactions between target-molecules and at least one analyte comprising: (a) contacting a plurality of target-molecules, said target-molecules being immobilized on a porous substrate, with a sample, said sample comprising at least one analyte; (b) incubating said target-molecules with said sample under conditions supporting target-molecule analyte interaction; (c) monitoring said interaction as defined in step (b), said monitoring being in function of time of incubation as defined in step (b); (d) optionally determining at least one interaction parameter; (e) varying said conditions as defined in step (b) by varying a reaction parameter, and; repeating, at least once, steps (c) to (e). The present invention further relates to the uses of said methods as well as to the use of a porous substrate for the preparation of a microarray kit for carrying out said methods.

Abstract: A system for conducting bioassays comprises a substrate plate with wells, and an incubation device for holding the plate. The substrate plate comprises a microplate with an array of wells arranged in rows and columns, wherein the bottom of each well is a microarray substrate having oriented flow-through channels. The incubation device comprises an incubation chamber fox holding the microplate and a cover for sealing the incubation chamber. The incubation device has a heat block with array of openings, each opening adapted to receive a well of the microplate. A sealing gasket is provided for individually sealing each well of the microplate.