Patents by Inventor Mario Alberto Flores-Valdez

Mario Alberto Flores-Valdez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of new BCG vaccine strains protecting against the establishment of latent infection and reactivation from the latent or persistent state
    Patent number: 7935354
    Abstract: A vaccine for treating or preventing the establishment of latent tuberculosis infections is provided. The vaccine comprises a recombinant mycobacterium that overexpresses the transcription factor DosR, at a level sufficient to induce production of the dosR regulon genes or proteins. A host to whom the vaccine is administered mounts an immune response to the dosR regulon proteins and is thus protected from the establishment, persistence or reactivation of latent tuberculosis.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: May 3, 2011
    Assignees: Aeras Global TB Vaccine Foundation, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Mario Alberto Flores-Valdez, Gary K. Schoolnik, Michel Klein, Jerald C. Sadoff, David Hone
  • GENERATION OF NEW BCG VACCINE STRAINS PROTECTING AGAINST THE ESTABLISHMENT OF LATENT MYCOBACTERIUM TUBERCULOSIS INFECTION AND REACTIVATION FROM THE LATENT OR PERSISTENT STATE
    Publication number: 20090123492
    Abstract: A vaccine for treating or preventing the establishment of latent tuberculosis infections is provided. The vaccine comprises a recombinant mycobacterium that overexpresses the transcription factor DosR, at a level sufficient to induce production of the dosR regulon genes or proteins. A host to whom the vaccine is administered mounts an immune response to the dosR regulon proteins and is thus protected from the establishment, persistence or reactivation of latent tuberculosis.
    Type: Application
    Filed: November 13, 2007
    Publication date: May 14, 2009
    Inventors: Mario Alberto Flores-Valdez, Gary K. Schoolnik, Michel Klein, Jerald C. Sadoff, David Hone