Patents by Inventor Mario B. Marrero

Mario B. Marrero has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT WITH ALPHA 7-SELECTIVE LIGANDS
    Publication number: 20110124678
    Abstract: The present invention includes methods, uses, and selective ?7 nAChR agonist compounds for treating or preventing metabolic disorders.
    Type: Application
    Filed: August 1, 2008
    Publication date: May 26, 2011
    Applicant: Targacept, Inc.
    Inventors: Merouane Bencherif, Mario B. Marrero
  • Methods and compositions for treatment of central nervous system disorders
    Patent number: 7067261
    Abstract: The invention provides methods of screening for substances having an effect on a nicotine receptor by contacting a cell having a nicotine receptor with a test substance; and determining any increase or decrease in phosphorylation of Janus-Activated Kinase 2 (JAK2). An increase in phosphorylation of JAK2 indicates that the test substance stimulates the nicotine receptor, and wherein a decrease in phosphorylation of JAK2 indicates that the test substance inhibits the nicotine receptor. The invention also provides screening methods for identification of substances that affect nicotine receptor activity through activity mediated by the AT2 receptor. Related pharmaceutical compositions and methods of treatment are also provided.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: June 27, 2006
    Assignees: Targacept, Inc., Medical College of Georgia Research Institute, Inc.
    Inventors: Merouane Bencherif, Mario B. Marrero
  • Methods and compositions for treatment of central nervous system disorders
    Publication number: 20030158211
    Abstract: The invention provides methods of screening for substances having an effect on a nicotine receptor by contacting a cell having a nicotine receptor with a test substance; and determining any increase or decrease in phosphorylation of Janus-Activated Kinase 2 (JAK2). An increase in phosphorylation of JAK2 indicates that the test substance stimulates the nicotine receptor, and wherein a decrease in phosphorylation of JAK2 indicates that the test substance inhibits the nicotine receptor. The invention also provides screening methods for identification of substances that affect nicotine receptor activity through activity mediated by the AT2 receptor. Related pharmaceutical compositions and methods of treatment are also provided.
    Type: Application
    Filed: December 13, 2002
    Publication date: August 21, 2003
    Inventors: Merouane Bencherif, Mario B. Marrero