Abstract: A portable system for producing a formulation comprising lipid nanoparticle (LNP)-encapsulated RNA includes: a first sub-system comprising multiple drug substance formulation modules, the first sub-system comprising: a transcription module for forming an RNA solution via in vitro transcription; and a second sub-system operatively downstream of the first sub-system comprising multiple drug product formation modules, the second sub-system comprising: an LNP formulation module for producing a first RNA-LNP preparation from the RNA solution, wherein each of the transcription module and the LNP formulation module is contained within a separate standard shipping container.

Abstract: A rotor of a dynamo-electric rotary machine includes a rotor core arranged concentrically to a rotor axis and including slots filled with electrically conductive material. A front ring is arranged at a front axial end of the slots and includes electrically conductive material, and a rear ring is arranged at a rear axial end of the slots and includes electrically conductive material. A rotor-core-distal surface of the front ring and/or rear ring has a bevel in axial direction from an outer circumference to an inner circumference, with the bevel defined by a bevel angle having a value of 3° to 30°. A support element is at least partially connected to the front and/or rear ring with a positive fit and pressed thereon axially, with the support element being supported on a shaft and having a radial end which terminates at a radial end of the front and/or rear ring.