Abstract: Needle insertion mechanisms include a housing and a needle holder, the needle holder being linearly guided by the housing to be moved along the needle-axis. A slider linearly guided by the housing and transversally moveable with respect to the needle-axis from a first to a second slider position. The needle holder is operatively coupled to the slider when the slider is in the first position, thereby retaining the needle holder in a retracted position against the bias of a spring acting on the needle holder. In the second position the slider is decoupled from the needle holder and the holder is moved into an inserted position by the spring. A blocking member arranged between the slider and the housing blocking movement of the slider into the second position, is moved by an active drive thereby unblocking the movement of the slider and subsequently moving the slider to the second position.

Abstract: A needle insertion and retraction mechanism for a medication delivery device includes a housing and a needle carrier holding a needle guided by the housing and moved along a needle axis. A first spring member is adapted to move the carrier in an insertion direction. A second spring member is adapted to retract the carrier in a retraction direction, opposite the insertion direction. A control element, linearly guided by the housing, moves transversely to the needle axis from a starting position, via a needle insertion release position, to a needle retraction release position. At least one of the first spring member and the second spring member is mounted on the control element so that the respective spring member is movable together with the control element.

Abstract: An injection device for delivery of a fluid medicament including a housing (2) defining a longitudinal axis and enclosing an injection mechanism. An end cap (12) is fixed to the housing (2) thereby delimiting the injection mechanism in a proximal direction. A closure cap (17) closes the injection device (20) and is connected to the end cap (12) by a mechanical interface (12e, 12f, 17a) configured to be released by rotating the closure cap (17) relative to the housing (2) around the longitudinal axis. A locking plate (16c) is positioned between the closure cap (17) and the end cap (12), and the closure cap (17) is coupled to the locking plate (16c) by a first coupling (17b, 16d) and the locking plate (16c) is coupled to the end cap (12) by a second coupling (16f, 12d) thereby preventing rotation of the closure cap (17) with respect to the housing (2).

Abstract: A crimp for affixing a septum to a neck portion of a medicament cartridge includes a cylindrical skirt section made from a deformable material configured for attachment to the neck portion of the cartridge, an end wall connected to the cylindrical skirt section and arranged substantially perpendicular to a longitudinal axis of the cylindrical skirt section, the end wall defining a passage, and a film attached to the end wall, wherein the film closes the passage and is made from a flexible, porous membrane. A section of the film covering the passage includes lateral dimensions that exceed lateral dimensions of the passage such that the film closes the passage and forms a sterile barrier. An assembly may include the crimp along with a cartridge and a septum.

Abstract: A needle insertion and retraction mechanism for a medication delivery device includes a housing and a needle carrier holding a needle guided by the housing and moved along a needle axis. A first spring member is adapted to move the carrier in an insertion direction. A second spring member is adapted to retract the carrier in a retraction direction, opposite the insertion direction. A control element, linearly guided by the housing, moves transversely to the needle axis from a starting position, via a needle insertion release position, to a needle retraction release position. When the control element is in its starting position, the control element is coupled to the carrier to prevent the carrier from moving in the insertion direction. When the control element is in the release position, the control element is decoupled from the carrier and the first spring member drives the carrier in the needle insertion direction.

Abstract: An assembly for an injection or infusion device includes i) a cartridge being closed by a septum and the surface of the septum being sterile and covered by a first continuous flexible strip, and ii) a fluid path unit comprising a cartridge holder and a fluid path compartment comprising a needle in an interior, the needle is configured to penetrate the septum of the cartridge through a passage in the fluid path compartment. The passage is closed by a second continuous flexible strip keeping the interior of the fluid path compartment in a sterile condition. The cartridge is inserted into the cartridge holder aligning the septum with the passage and sandwiching both strips between the septum and the fluid path compartment. Both strips may be simultaneously removable from the cartridge and fluid path compartment thereby, establishing a sterile connection between the septum and the interior of the fluid path compartment.

Abstract: An autoinjector including a drive device with a first housing part and a product container receiving device with a second housing part are connectable coaxially via a connection-side end portion on one of the two housing parts which is stepped in such a way that it can be inserted into the other of the two housing parts, and in the region of the end portion, a first snap-in connection and a second and third snap-in connection are provided, which can be snapped into place, one after the other, in the joining direction, and the first of the snap-in connections can be released against the joining direction, and at least the third or final snap-in connection is locked. Methods for the final assembly of the autoinjector involve establishing the snap-in connections for initially permitting release of the two housing parts and then ultimately locking them together.

Abstract: An injection device for delivery of a fluid medicament includes a housing defining a longitudinal axis and enclosing an injection mechanism. An end cap is fixed to the housing and limits the injection mechanism in a proximal direction. A closure cap is releasably connected to the end cap by a releasable snap fit connection thereby closing the injection device. The releasable snap fit connection is established before medicament delivery by relative axial movement along the longitudinal axis between the closure cap and the housing whereby a wall of the closure cap is elastically deformed, and the releasable snap fit connection is configured to be released after medicament delivery by relative rotational movement around the longitudinal axis between the closure cap and the housing whereby the wall of the closure cap is elastically deformed.

Abstract: A product container receptacle and an autoinjector may include: a syringe holder for accommodating a pre-filled, ready-to-use syringe defining a longitudinal axis, with a cylindrical product container that narrows at its distal end via a shoulder, and a needle protection cap. The syringe holder includes a distally, coaxially arranged guide sleeve on the inner wall of which a blocking surface is formed; an insert having a snap arm, which is radially deflectable with respect to the longitudinal axis from a relaxed position and has a snap hook; and a detachable device cap in which the insert is connectably accommodated. The insert is movable relative to the device cap from a first latching position to a second latching position, and the connection of the device cap to the insert, in at least the second latching position, is configured to latch and form-fit with respect to tensile forces.

Abstract: An injection device configured for attachment to the skin of a patient includes a housing and a skin adhesive layer attached to an external surface of the housing for attaching the injection device to the skin of a patient. A release liner covering the skin adhesive layer prevents the injection device from attaching to the skin. A film with one end connected to a surface inside of the housing forms a removable sterile barrier and the other end connected to an external surface of the release liner without contacting the skin adhesive layer. The housing, skin adhesive layer and release liner each include a notch defining a passage for the film so that the second end of the film can extend from the interior to the exterior of the housing.

Abstract: An injection device configured for attachment to the skin of a patient using an adhesive layer includes a release liner covering the adhesive layer thereby preventing skin attachment. The release liner comprises a sheet of material where a first surface contacts the adhesive layer, and an aperture defining a passage for a film connected to a first sterile barrier film located within the injection device. An end of the film is connected to a second surface of the sheet of material that is opposite to the first surface, and the release liner is covered by a strengthening sheet connected to the second surface and covering the aperture and the end of the film.

Abstract: An autoinjector for dispensing a liquid product, particularly a drug, comprising: an electronic module with a sensor configured to measure the axial movement of a signal element (11) from a position at the start of the dispensing, wherein the signal element (11) is slaved in the dispensing direction, to a position at the end of the dispensing, wherein the signal element (11) strikes the signal stop (12a).

Abstract: An electronic add-on module for an injection device includes a longitudinal axis and a discharge button arranged at a proximal end and configured to be movable in a distal direction along the longitudinal axis for discharging a liquid medication out of a container of the injection device. The add-on module includes a sensor unit, a receiving region adapted to the shape of the housing of the injection device for placing on along the longitudinal axis thereof, and a holding mechanism configured to releasably secure the add-on module against moving axially relative to the injection device. The receiving region is configured such that the discharge button can be accessed or contacted when the add-on module is on the injection device. The add-on module comprises a release element configured to be moved solely on a plane perpendicular to the longitudinal axis in a release movement for releasing the holding mechanism.

Abstract: Needle insertion mechanisms include a housing and a needle holder, the needle holder being linearly guided by the housing to be moved along the needle-axis. A slider linearly guided by the housing and transversally moveable with respect to the needle-axis from a first to a second slider position. The needle holder is operatively coupled to the slider when the slider is in the first position, thereby retaining the needle holder in a retracted position against the bias of a spring acting on the needle holder. In the second position the slider is decoupled from the needle holder and the holder is moved into an inserted position by the spring. A blocking member arranged between the slider and the housing blocking movement of the slider into the second position, is moved by an active drive thereby unblocking the movement of the slider and subsequently moving the slider to the second position.

Abstract: An assembly for a cartridge needle insertion mechanism includes a housing, a cartridge needle defining a cartridge needle axis and a cartridge closed by a septum. A cartridge needle slider is linearly guided by the housing along an insertion axis to be moved by a driver from a first position, where the cartridge needle is not penetrating the septum, to a second position where the cartridge needle penetrates the septum of the cartridge. A cartridge needle holder holding the cartridge needle is operatively coupled with the cartridge needle slider to be moved with the cartridge needle slider from the first to the second position. The assembly includes a compliant coupling between the cartridge needle holder and the cartridge needle slider configured to facilitate movement of the cartridge needle holder with respect to the slider when moved into the second position, thereby compensating for needle penetration forces.

Abstract: An injection device for distributing a liquid product, in particular a medicament, includes: a) a housing with a longitudinal axis (L) and a product container, in particular a syringe, provided in the housing, the product container including a displaceable plunger, where the plunger can be displaced along the longitudinal axis (L) in a distal direction using a propulsion member to distribute the product contained in the product container; b) a cover cap which is mounted on the distal end of the housing and which can be removed from the housing; and c) a mechanism which prevents the cover cap from being remounted on the distal end of the housing.

Abstract: A needle insertion and retraction mechanism for a medication delivery device includes a housing and a needle carrier holding a needle guided by the housing and moved along a needle axis. A first spring member is adapted to move the carrier in an insertion direction. A second spring member is adapted to retract the carrier in a retraction direction, opposite the insertion direction. A control element, linearly guided by the housing, moves transversely to the needle axis from a starting position, via a needle insertion release position, to a needle retraction release position. When the control element is in its starting position, the control element is coupled to the carrier to prevent the carrier from moving in the insertion direction. When the control element is in the release position, the control element is decoupled from the carrier and the first spring member drives the carrier in the needle insertion direction.

Abstract: An assembly for an injection or infusion device includes i) a cartridge being closed by a septum and the surface of the septum being sterile and covered by a first continuous flexible strip, and ii) a fluid path unit comprising a cartridge holder and a fluid path compartment comprising a needle in an interior, the needle is configured to penetrate the septum of the cartridge through a passage in the fluid path compartment. The passage is closed by a second continuous flexible strip keeping the interior of the fluid path compartment in a sterile condition. The cartridge is inserted into the cartridge holder aligning the septum with the passage and sandwiching both strips between the septum and the fluid path compartment. Both strips may be simultaneously removable from the cartridge and fluid path compartment thereby, establishing a sterile connection between the septum and the interior of the fluid path compartment.

Abstract: An injection device configured for attachment to the skin of a patient includes a housing and a skin adhesive layer attached to an external surface of the housing for attaching the injection device to the skin of a patient. A release liner covering the skin adhesive layer prevents the injection device from attaching to the skin. A film with one end connected to a surface inside of the housing forms a removable sterile barrier and the other end connected to an external surface of the release liner without contacting the skin adhesive layer. The housing, skin adhesive layer and release liner each include a notch defining a passage for the film so that the second end of the film can extend from the interior to the exterior of the housing.