Abstract: An aerosolizable liquid formulation for inhalation includes one or more active pharmaceutical ingredients dissolved in a solvent. The one or more active pharmaceutical ingredients includes a vasodilator active pharmaceutical ingredient and, optionally, non-vasodilator active pharmaceutical ingredient.

Abstract: An electronic device includes a hand held base assembly that includes circuitry including memory and firmware executed by a processor or microcontroller of the circuitry; and a cartridge assembly that includes memory that is read by the firmware of the handheld base assembly. The cartridge assembly and the handheld base assembly are configured to removably couple together to define the electronic device for producing an aerosol for inhalation by a person. An enclosed air passageway is defined by the cartridge assembly and by the handheld base assembly, which isolates the airflow from the electronics of the device. The enclosed air passageway extends between the opening of the mouthpiece for taking a breath and a diaphragm of the handheld base assembly, movement of the diaphragm changing the air pressure within an enclosed interior space having a pressure sensor for trigging the pressure sensor when a breath is taken.

Abstract: An electronic device includes a hand held base assembly that includes circuitry including memory and firmware executed by a processor or microcontroller of the circuitry; and a cartridge assembly that includes memory that is read by the firmware of the handheld base assembly. The cartridge assembly and the handheld base assembly are configured to removably couple together to define the electronic device for producing an aerosol for inhalation by a person. An enclosed air passageway is defined by the cartridge assembly and by the handheld base assembly, which isolates the airflow from the electronics of the device. The enclosed air passageway extends between the opening of the mouthpiece for taking a breath and a diaphragm of the handheld base assembly, movement of the diaphragm changing the air pressure within an enclosed interior space having a pressure sensor for trigging the pressure sensor when a breath is taken.

Abstract: An electronic device includes a hand held base assembly that includes circuitry including memory and firmware executed by a processor or microcontroller of the circuitry; and a cartridge assembly that includes memory that is read by the firmware of the handheld base assembly. The cartridge assembly and the handheld base assembly are configured to removably couple together to define the electronic device for producing an aerosol for inhalation by a person. An enclosed air passageway is defined by the cartridge assembly and by the handheld base assembly, which isolates the airflow from the electronics of the device. The enclosed air passageway extends between the opening of the mouthpiece for taking a breath and a diaphragm of the handheld base assembly, movement of the diaphragm changing the air pressure within an enclosed interior space having a pressure sensor for trigging the pressure sensor when a breath is taken.

Abstract: An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece, a liquid container, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the container. The mesh material is configured to vibrate when the piezoelectric material is actuated, whereby the aerosol is produced. The aerosol may be inhaled through the mouthpiece. The device also includes circuitry and a power supply for actuating the mesh assembly. The mouthpiece, the container, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the container. The mesh material has a rigidity that is sufficient to prevent oscillations of varying amplitudes during actuation of the piezoelectric material of the mesh assembly for consistently producing the aerosol.

Abstract: An electronic device includes a mouthpiece, a bladder, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the bladder. The mouthpiece, the bladder, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the bladder. A liquid-filled cartridge also is disclosed for use with an electronic device for delivery of a substance into a body through respiration includes a liquid container; and a liquid contained within the container for aerosolizing and inhaling by a person using the electronic device. The liquid includes a plurality of nanoparticles in a nanoemulsion, the nanoparticles including the encapsulation of the substance to be delivered into the body through respiration. The nanoemulsion preferably is produced using a microfluidizing machine.

Abstract: An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece, a liquid container, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the container. The mesh material is configured to vibrate when the piezoelectric material is actuated, whereby the aerosol is produced. The aerosol may be inhaled through the mouthpiece. The device also includes circuitry and a power supply for actuating the mesh assembly. The mouthpiece, the container, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the container. The mesh material has a rigidity that is sufficient to prevent oscillations of varying amplitudes during actuation of the piezoelectric material of the mesh assembly for consistently producing the aerosol.

Abstract: An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece located at one of opposite longitudinal ends of the device; a liquid container; a transducer that, when actuated, causes a liquid from the container to be aerosolized such that the aerosol may be inhaled from the device by a person through the mouthpiece; and circuitry and a power supply for actuating the transducer. The mouthpiece, the container, and the transducer are located in-line along a longitudinal axis of a housing of the device extending between the opposite longitudinal ends of the device. The container is located between and separates the transducer and the mouthpiece. The container and the transducer are contained within a cartridge that is insertable into and removable from the housing of the device. The container and the transducer are replaceable by the person when the liquid in the container is depleted.

Abstract: An electronic device for producing an aerosol for inhalation has a mouthpiece and an elongate housing. The mouthpiece attaches to an upper end of the housing. The housing contains a liquid container and a mesh assembly with mesh material that vibrates when actuated for aerosolizing liquid from the container. The mouthpiece covers the mesh assembly at the upper end of the housing, and the aerosol produced by the mesh assembly may be inhaled through the mouthpiece by a person. The housing contains circuitry and a power supply, preferably are located in a lower half of the housing, for actuating vibration of the mesh material. Electrical pathways connect the mesh assembly with the circuitry and power supply. The power supply may comprise one or more batteries located at the lower end of the housing. The aerosol is produced without smoldering of the liquid and without using a compressed gas.

Abstract: An electronic device includes a mouthpiece, a bladder, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the bladder. The mouthpiece, the bladder, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the bladder. A liquid-filled cartridge also is disclosed for use with an electronic device and includes a bladder; and a liquid contained within the container for aerosolizing and inhaling by a person using the electronic device. The liquid includes an aqueous formulation including a saline component, an acid component, and a nicotine component. The acid component includes a lactic acid. The aqueous formulation optionally includes one or more of a menthol component, an ethanol component, and a surfactant component.

Abstract: An electronic device includes a mouthpiece, a bladder, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the bladder. The mouthpiece, the bladder, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the bladder. A liquid-filled cartridge also is disclosed for use with an electronic device and includes a bladder; and a liquid contained within the container for aerosolizing and inhaling by a person using the electronic device. The liquid includes an aqueous formulation including a saline component, an acid component, and a nicotine component. The acid component includes a lactic acid. The aqueous formulation optionally includes one or more of a menthol component, an ethanol component, and a surfactant component.

Abstract: An exemplary ankle brace includes an inner sleeve, an outer sleeve, a medial guide, a lateral guide, a top guide, and a bottom guide. The brace also includes a medial strap and a lateral strap positioned around the user's ankle between the inner sleeve and the outer sleeve. The medial strap and the lateral strap are configured to tighten the inner sleeve. The brace also includes a collar strap positioned around a tibia and a fibula of the user between the inner sleeve and the outer sleeve. The collar strap is configured to tighten the inner sleeve such that the ankle brace maintains a predetermined height on the user's ankle. The brace also includes a pocket adapted to receive a removable arch support.

Abstract: An electronic device includes a mouthpiece, a bladder, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the bladder. The mouthpiece, the bladder, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the bladder. A liquid-filled cartridge also is disclosed for use with an electronic device for delivery of a substance into a body through respiration includes a liquid container; and a liquid contained within the container for aerosolizing and inhaling by a person using the electronic device. The liquid includes a plurality of nanoparticles in a nanoemulsion, the nanoparticles including the encapsulation of the substance to be delivered into the body through respiration. The nanoemulsion preferably is produced using a microfluidizing machine.

Abstract: A disposable cartridge is disclosed for use with an electronic device for producing an aerosol for inhalation by a person. The cartridge comprises a liquid container containing a liquid which when aerosolized is intended for inhalation by a person; and a transducer that, when actuated, causes the liquid from the container to be aerosolized such that the aerosol may be inhaled by a person. In various embodiments, the liquid comprises: a liposomal carrier; a liquid mixture having an active agent entrapped by liposomes; and a liquid mixture comprising a nanodispersion. The liquid may include nicotine, tetrahydrocannabinol, cannabidiol, or nanoparticles formed by an oil droplet covered by a monolayer of phosphatidylcholine. The transducer preferably comprises a mesh material with the transducer and the mesh material forming a piezo mesh disk for aerosolizing the liquid.

Abstract: An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece located at one of opposite longitudinal ends of the device; a liquid container; a transducer that, when actuated, causes a liquid from the container to be aerosolized such that the aerosol may be inhaled from the device by a person through the mouthpiece; and circuitry and a power supply for actuating the transducer. The mouthpiece, the container, and the transducer are located in-line along a longitudinal axis of a housing of the device extending between the opposite longitudinal ends of the device. The container is located between and separates the transducer and the mouthpiece. The container and the transducer are contained within a cartridge that is insertable into and removable from the housing of the device. The container and the transducer are replaceable by the person when the liquid in the container is depleted.

Abstract: A disposable cartridge is disclosed for use with an electronic device for producing an aerosol for inhalation by a person. The cartridge comprises a liquid container containing a liquid which when aerosolized is intended for inhalation by a person; and a transducer that, when actuated, causes the liquid from the container to be aerosolized such that the aerosol may be inhaled by a person. In various embodiments, the liquid comprises: a liposomal carrier; a liquid mixture having an active agent entrapped by liposomes; and a liquid mixture comprising a nanodispersion. The liquid may include nicotine, tetrahydrocannabinol, cannabidiol, or nanoparticles formed by an oil droplet covered by a monolayer of phosphatidylcholine. The transducer preferably comprises a mesh material with the transducer and the mesh material forming a piezo mesh disk for aerosolizing the liquid.

Abstract: Methods of preparing inhalable supplements are disclosed. The methods involve aerosolizing a liquid comprising a carrier and a supplement by heating the liquid to a temperature that retains the bioavailability of the supplement. Also disclosed are methods and kits for treating a subject with an inhalable supplement.

Abstract: An electronic device for producing an aerosol for inhalation has a mouthpiece and an elongate housing. The mouthpiece attaches to an upper end of the housing. The housing contains a liquid container and a mesh assembly with mesh material that vibrates when actuated for aerosolizing liquid from the container. The mouthpiece covers the mesh assembly at the upper end of the housing, and the aerosol produced by the mesh assembly may be inhaled through the mouthpiece by a person. The housing contains circuitry and a power supply, preferably are located in a lower half of the housing, for actuating vibration of the mesh material. Electrical pathways connect the mesh assembly with the circuitry and power supply. The power supply may comprise one or more batteries located at the lower end of the housing. The aerosol is produced without smoldering of the liquid and without using a compressed gas.

Abstract: An electronic device for producing an aerosol for inhalation by a person includes a mouthpiece, a liquid container, and a mesh assembly having a mesh material and a piezoelectric material. The mesh material is in contact with a liquid of the container. The mesh material is configured to vibrate when the piezoelectric material is actuated, whereby the aerosol is produced. The aerosol may be inhaled through the mouthpiece. The device also includes circuitry and a power supply for actuating the mesh assembly. The mouthpiece, the container, and the mesh assembly are located in-line along a longitudinal axis of the device between opposite longitudinal ends of the device, with the mesh assembly extending between and separating the mouthpiece and the container. The mesh material has a rigidity that is sufficient to prevent oscillations of varying amplitudes during actuation of the piezoelectric material of the mesh assembly for consistently producing the aerosol.

Abstract: Methods of preparing inhalable supplements are disclosed. The methods involve aerosolizing a liquid comprising a carrier and a supplement by heating the liquid to a temperature that retains the bioavailability of the supplement.